(Q37602377)

21 August 2017

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title

Inhibiting PI3K as a therapeutic strategy against cancer (English)

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21 August 2017

author

Carmen Blanco-Aparicio

object named as

Carmen Blanco-Aparicio

2

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Rocío García-Carbonero

object named as

Rocío García-Carbonero

3

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Amancio Carnero

object named as

Amancio Carnero

4

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author name string

Luis Paz-Ares

1

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21 August 2017

publication date

1 September 2009

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Clinical and Translational Oncology

21 August 2017

published in

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21 August 2017

volume

11

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21 August 2017

issue

9

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21 August 2017

page(s)

572-579

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https://scigraph.springernature.com/pub.10.1007/s12094-009-0407-x

21 August 2017

exact match

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cites work

Novel targets of Akt, p21(Cipl/WAF1), and MDM2.

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS12094-009-0407-X

Activation of intracellular kinases in Xenopus oocytes by p21ras and phospholipases: a comparative study

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS12094-009-0407-X

Oncogenic PI3K and its role in cancer

21 January 2018

1 reference

12 December 2020

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

1 reference

12 December 2020

Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel

1 reference

12 December 2020

Mutation of the PIK3CA gene in ovarian and breast cancer

1 reference

12 December 2020

Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation

1 reference

12 December 2020

The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

1 reference

12 December 2020

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

1 reference

12 December 2020

Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

1 reference

12 December 2020

PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome

1 reference

12 December 2020

Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway

1 reference

12 December 2020

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

1 reference

12 December 2020

Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms

1 reference

12 December 2020

Reduction in the requirement of oncogenic Ras signaling to activation of PI3K/AKT pathway during tumor maintenance

1 reference

12 December 2020

The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts

1 reference

12 December 2020

Inhibition of phosphatidylinositide 3-kinase enhances gemcitabine-induced apoptosis in human pancreatic cancer cells.

1 reference

12 December 2020

Ral-GTPases: approaching their 15 minutes of fame

1 reference

12 December 2020

Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling

1 reference

12 December 2020

The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network

1 reference

12 December 2020

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

1 reference

12 December 2020

Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction.

1 reference

12 December 2020

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

1 reference

12 December 2020

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

1 reference

12 December 2020

Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation

1 reference

12 December 2020

Akt-dependent transformation: there is more to growth than just surviving

1 reference

12 December 2020

Cancer-specific mutations in PIK3CA are oncogenic in vivo

1 reference

12 December 2020

Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action

1 reference

12 December 2020

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

12 December 2020

Mutation of the PIK3CA gene in anaplastic thyroid cancer.

1 reference

12 December 2020

Absence of p21WAF1 cooperates with c-myc in bypassing Ras-induced senescence and enhances oncogenic cooperation

1 reference

12 December 2020

Exploring the specificity of the PI3K family inhibitor LY294002.

1 reference

12 December 2020

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

1 reference

12 December 2020

Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3'-kinase inhibition in the KM20 human colon cancer cell line.

1 reference

12 December 2020

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

1 reference

12 December 2020

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

1 reference

12 December 2020

Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species

1 reference

12 December 2020

Membrane localization of all class I PI 3-kinase isoforms suppresses c-Myc-induced apoptosis in Rat1 fibroblasts via Akt.

1 reference

12 December 2020

Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

1 reference

12 December 2020

The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells

1 reference

12 December 2020

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

12 December 2020

Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis

1 reference

12 December 2020

Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria

1 reference

12 December 2020

1 reference

12 December 2020

Genetic modelling of the PTEN/AKT pathway in cancer research

1 reference

12 December 2020

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

1 reference

12 December 2020

The many forks in FOXO's road

1 reference

12 December 2020

AKT activation predicts outcome in breast cancer patients treated with tamoxifen

1 reference

12 December 2020

Cellular survival: a play in three Akts

1 reference

12 December 2020

The rationale for the combination of selective EGFR inhibitors with cytotoxic drugs and radiotherapy.

1 reference

12 December 2020

Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

1 reference

12 December 2020

The proteasome as a potential target for novel anticancer drugs and chemosensitizers

1 reference

12 December 2020

A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16

1 reference

12 December 2020

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

1 reference

12 December 2020

Response and determinants of cancer cell susceptibility to PI3K inhibitors: combined targeting of PI3K and Mek1 as an effective anticancer strategy

1 reference

12 December 2020

Evidence for different signalling pathways of PKC zeta and ras-p21 in Xenopus oocytes.

1 reference

12 December 2020

Understanding Ras: 'it ain't over 'til it's over'.

1 reference

12 December 2020

PTEN, a unique tumor suppressor gene

1 reference

12 December 2020

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

1 reference

12 December 2020

Ras signaling, deregulation of gene expression and oncogenesis.

1 reference

12 December 2020

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

12 December 2020

The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

1 reference

12 December 2020

Clinical and pathological features of breast disease in Cowden's syndrome: an underrecognized syndrome with an increased risk of breast cancer

1 reference

12 December 2020

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

1 reference

12 December 2020

Colorectal cancer: mutations in a signalling pathway

1 reference

12 December 2020

ras oncogenes in human cancer: a review

1 reference

12 December 2020

The PIK3CA gene is mutated with high frequency in human breast cancers.

1 reference

12 December 2020

High frequency of mutations of the PIK3CA gene in human cancers

1 reference

12 December 2020

Species- and cell type-specific requirements for cellular transformation

1 reference

12 December 2020

Targeting RAS signalling pathways in cancer therapy

1 reference

12 December 2020

PI 3-kinase, Akt and cell survival

1 reference

12 December 2020

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

1 reference

12 December 2020

Affinity with Raf is sufficient for Ras to efficiently induce rat mammary carcinomas

1 reference

12 December 2020

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

1 reference

12 December 2020

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

1 reference

12 December 2020

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

1 reference

12 December 2020

PTEN, more than the AKT pathway

1 reference

12 December 2020

Akt signaling and cancer: surviving but not moving on.

1 reference

12 December 2020

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

1 reference

12 December 2020

Genetic Alterations in Esophageal Cancer

1 reference

12 December 2020

Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models

1 reference

12 December 2020

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

1 reference

12 December 2020

Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models.

1 reference

12 December 2020

Class I PI3K in oncogenic cellular transformation.

1 reference

12 December 2020

Activation of phosphatidylinositol 3-kinase by membrane localization of p110alpha predisposes mammary glands to neoplastic transformation

1 reference

12 December 2020

1 reference

12 December 2020

A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance

1 reference

12 December 2020

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

1 reference

12 December 2020

A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity

1 reference

12 December 2020

Rat mammary carcinogenesis induced by in situ expression of constitutive Raf kinase activity is prevented by tethering Raf to the plasma membrane

1 reference

12 December 2020

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate

1 reference

12 December 2020

Ten years of protein kinase B signalling: a hard Akt to follow

1 reference

12 December 2020

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

12 December 2020

Chemically targeting the PI3K family

1 reference

12 December 2020

Blocking the PI3K/PKB pathway in tumor cells

1 reference

12 December 2020

The complexity of Raf-1 regulation

1 reference

12 December 2020

PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer

1 reference

12 December 2020

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

1 reference

12 December 2020

Drug discovery approaches targeting the PI3K/Akt pathway in cancer

1 reference

12 December 2020

PI3K pathway alterations in cancer: variations on a theme

1 reference

12 December 2020

Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy

1 reference

12 December 2020

The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.

1 reference

12 December 2020

10.1007/S12094-009-0407-X

Identifiers

DOI

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21 August 2017

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