(Q37641731)

21 August 2017

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title

Proteomic identification of multitasking proteins in unexpected locations complicates drug targeting (English)

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21 August 2017

2

Christopher M Overall

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21 August 2017

1

Georgina S Butler

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21 August 2017

1 December 2009

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Nature Reviews Drug Discovery

21 August 2017

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21 August 2017

8

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21 August 2017

12

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21 August 2017

935-948

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https://scigraph.springernature.com/pub.10.1038/nrd2945

21 August 2017

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31 March 2020

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A human protein-protein interaction network: a resource for annotating the proteome

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A new approach to decoding life: systems biology

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Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding

31 March 2020

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Proteomic analysis identifies protein targets responsible for depsipeptide sensitivity in tumor cells

31 March 2020

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Proteomic identification of heat shock protein 70 as a candidate target for enhancing apoptosis induced by farnesyl transferase inhibitor.

31 March 2020

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Proteome analysis of vinca alkaloid response and resistance in acute lymphoblastic leukemia reveals novel cytoskeletal alterations.

31 March 2020

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Identifying the proteins to which small-molecule probes and drugs bind in cells

31 March 2020

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Initial sequencing and analysis of the human genome

31 March 2020

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The genome sequence of Drosophila melanogaster

31 March 2020

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Multifunctional proteins: examples of gene sharing

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Gene sharing in lens and cornea: facts and implications

31 March 2020

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Metadegradomics: toward in vivo quantitative degradomics of proteolytic post-translational modifications of the cancer proteome.

31 March 2020

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Pericellular cathepsin B and malignant progression

31 March 2020

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A proteomic approach towards the Hsp90-dependent ubiquitinylated proteome.

31 March 2020

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Heat shock protein 90 as a drug target: some like it hot.

31 March 2020

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Development and application of Hsp90 inhibitors

31 March 2020

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Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing

31 March 2020

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Proteomics: the first decade and beyond

31 March 2020

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Capabilities using 2-D DIGE in proteomics research : the new gold standard for 2-D gel electrophoresis

31 March 2020

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Mass spectrometry-based proteomics

31 March 2020

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Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness

31 March 2020

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The novel fragment of tyrosyl tRNA synthetase, mini-TyrRS, is secreted to induce an angiogenic response in endothelial cells

31 March 2020

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Human lysyl-tRNA synthetase is secreted to trigger proinflammatory response

31 March 2020

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HMG-1 as a late mediator of endotoxin lethality in mice

31 March 2020

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Aminoacyl-tRNA synthetase complexes: beyond translation

31 March 2020

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A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase

31 March 2020

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Molecular characterization and expression of the gene encoding human erythroid-potentiating activity

31 March 2020

1 reference

Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

31 March 2020

1 reference

Purification of rabbit bone inhibitor of collagenase

31 March 2020

1 reference

An inhibitor of collagenase from human amniotic fluid. Purification, characterization and action on metalloproteinases

31 March 2020

1 reference

Tissue inhibitor of metalloproteinases from human bone marrow stromal cell line KM 102 has erythroid-potentiating activity, suggesting its possibly bifunctional role in the hematopoietic microenvironment

31 March 2020

1 reference

Molecular cloning and expression of neuroleukin, a neurotrophic factor for spinal and sensory neurons

31 March 2020

1 reference

Cloning of a glucose phosphate isomerase/neuroleukin-like sperm antigen involved in sperm agglutination

31 March 2020

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Mouse glucose-6-phosphate isomerase and neuroleukin have identical 3' sequences

31 March 2020

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A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor

31 March 2020

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Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation.

31 March 2020

1 reference

Intracellular targets of matrix metalloproteinase-2 in cardiac disease: rationale and therapeutic approaches

31 March 2020

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Mislocalization and unconventional functions of cellular MMPs in cancer.

31 March 2020

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Atypical localization of membrane type 1-matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma

31 March 2020

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Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis.

31 March 2020

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Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene

31 March 2020

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Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165

31 March 2020

1 reference

Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates

31 March 2020

1 reference

Identification of candidate angiogenic inhibitors processed by matrix metalloproteinase 2 (MMP-2) in cell-based proteomic screens: disruption of vascular endothelial growth factor (VEGF)/heparin affin regulatory peptide (pleiotrophin) and VEGF/Conne

31 March 2020

1 reference

Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability

31 March 2020

1 reference

Expression of the disintegrin metalloprotease, ADAM-10, in prostate cancer and its regulation by dihydrotestosterone, insulin-like growth factor I, and epidermal growth factor in the prostate cancer cell model LNCaP.

31 March 2020

1 reference

Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer

31 March 2020

1 reference

Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells

31 March 2020

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Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factor

31 March 2020

1 reference

Proteomic analysis of lysosomal acid hydrolases secreted by osteoclasts: implications for lytic enzyme transport and bone metabolism

31 March 2020

1 reference

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.

31 March 2020

1 reference

Neutrophil extracellular traps: casting the NET over pathogenesis.

31 March 2020

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Novel cell death program leads to neutrophil extracellular traps

31 March 2020

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Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

31 March 2020

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Neutrophil NETs: a novel contributor to preeclampsia-associated placental hypoxia?

31 March 2020

1 reference

RNaseE and the other constituents of the RNA degradosome are components of the bacterial cytoskeleton

31 March 2020

1 reference

Unconventional secretory routes: direct protein export across the plasma membrane of mammalian cells

31 March 2020

1 reference

Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function

31 March 2020

1 reference

The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts

31 March 2020

1 reference

Gelsolin inhibits the fibrillization of amyloid beta-protein, and also defibrillizes its preformed fibrils

31 March 2020

1 reference

The DNA base excision repair protein Ape1/Ref-1 as a therapeutic and chemopreventive target

31 March 2020

1 reference

Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.

31 March 2020

1 reference

Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy.

31 March 2020

1 reference

The Hsp90 mosaic: a picture emerges

31 March 2020

1 reference

Functional and quantitative proteomics using SILAC

31 March 2020

1 reference

Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3

31 March 2020

1 reference

Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration

31 March 2020

1 reference

The cryptome: a subset of the proteome, comprising cryptic peptides with distinct bioactivities

31 March 2020

1 reference

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

31 March 2020

1 reference

Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth

31 March 2020

1 reference

Membrane proteins with soluble counterparts: role of proteolysis in the release of transmembrane proteins

31 March 2020

1 reference

ECM and cell surface proteolysis: regulating cellular ecology

31 March 2020

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Membrane associated proteases and their inhibitors in tumour angiogenesis

31 March 2020

1 reference

The biochemical, biological, and pathological kaleidoscope of cell surface substrates processed by matrix metalloproteinases.

31 March 2020

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Making the cut: protease-mediated regulation of angiogenesis

31 March 2020

1 reference

Two distinct cytokines released from a human aminoacyl-tRNA synthetase

31 March 2020

1 reference

Tyrosyl-tRNA Synthetase: A Housekeeping Protein and an Attractive Harbinger of Cellular Death

31 March 2020

1 reference

Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3.

31 March 2020

1 reference

Proteomics discovery of metalloproteinase substrates in the cellular context by iTRAQ labeling reveals a diverse MMP-2 substrate degradome.

31 March 2020

1 reference

Proteomics studies reveal important information on small molecule therapeutics: a case study on plasma proteins

31 March 2020

1 reference

The molecular make-up of a tumour: proteomics in cancer research

31 March 2020

1 reference

Pharmacoproteomics in drug development

31 March 2020

1 reference

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

31 March 2020

1 reference

Pharmacoproteomic approach to the study of drug mode of action, toxicity, and resistance: applications in diabetes and cancer

31 March 2020

1 reference

A pharmacoproteomics study of the cancer cell line EKVX using capillary-LC/MS/MS.

31 March 2020

1 reference

Pharmacoproteomics study of cetuximab in nasopharyngeal carcinoma.

31 March 2020

1 reference

Proteomic analysis identifies oxidative stress induction by adaphostin.

31 March 2020

1 reference

A proteomic approach for evaluating the cell response to a novel histone deacetylase inhibitor in colon cancer cells

31 March 2020

1 reference

Quantitative proteomic and transcriptional analysis of the response to the p38 mitogen-activated protein kinase inhibitor SB203580 in transformed follicular lymphoma cells.

31 March 2020

1 reference

Exploiting the promiscuity of imatinib

31 March 2020

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Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion

31 March 2020

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HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism

31 March 2020

1 reference

Protease degradomics: a new challenge for proteomics

31 March 2020

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Proteomic discovery of protease substrates

31 March 2020

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Protease proteomics: revealing protease in vivo functions using systems biology approaches

31 March 2020

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Dynamic proteomics of individual cancer cells in response to a drug.

31 March 2020

1 reference

Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer.

31 March 2020

1 reference

Gene and protein expression profiling of human ovarian cancer cells treated with the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin.

31 March 2020

1 reference

Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells

31 March 2020

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Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone.

31 March 2020

1 reference

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

31 March 2020

1 reference

MMP Inhibitor Clinical Trials – The Past, Present, and Future

31 March 2020

1 reference

Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations

31 March 2020

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MMPs as therapeutic targets--still a viable option?

31 March 2020

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Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatment

31 March 2020

1 reference

Matrix metalloproteinases: they're not just for matrix anymore!

31 March 2020

1 reference

Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis

31 March 2020

1 reference

Matrix metalloproteinases and the regulation of tissue remodelling

31 March 2020

1 reference

New functions for the matrix metalloproteinases in cancer progression

31 March 2020

1 reference

Towards third generation matrix metalloproteinase inhibitors for cancer therapy

31 March 2020

1 reference

Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.

31 March 2020

1 reference

Cancer-related inflammation

31 March 2020

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Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice

31 March 2020

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Macrophage elastase (matrix metalloproteinase-12) suppresses growth of lung metastases

31 March 2020

1 reference

Dickkopf-1 is a master regulator of joint remodeling

31 March 2020

1 reference

Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor

31 March 2020

1 reference

Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins

31 March 2020

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The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts

31 March 2020

1 reference

Strategies for MMP inhibition in cancer: innovations for the post-trial era.

31 March 2020

1 reference

Therapeutic potential of HMGB1-targeting agents in sepsis

31 March 2020

1 reference

A common conformationally coupled ATPase mechanism for yeast and human cytoplasmic HSP90s

31 March 2020

1 reference

The Hsp90 molecular chaperone: an open and shut case for treatment

31 March 2020

1 reference

SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers

31 March 2020

1 reference

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

31 March 2020

1 reference

A proteomic snapshot of the human heat shock protein 90 interactome

31 March 2020

1 reference

Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone

31 March 2020

1 reference

A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p).

31 March 2020

1 reference

The hsp90 molecular chaperone modulates multiple telomerase activities

31 March 2020

1 reference

A human nuclear uracil DNA glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate dehydrogenase

31 March 2020

1 reference

Proteomic analysis of exosomes secreted by human mesothelioma cells

31 March 2020

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Regulation of tumor cell mitochondrial homeostasis by an organelle-specific Hsp90 chaperone network.

31 March 2020

1 reference

Hsp90: the vulnerable chaperone

31 March 2020

1 reference

Interactions of a Purified Non-Histone Chromosomal Protein with DNA and Histone

31 March 2020

1 reference

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes

31 March 2020

1 reference

Protective effect of antagonist of high-mobility group box 1 on lipopolysaccharide-induced acute lung injury in mice

31 March 2020

1 reference

High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

31 March 2020

1 reference

Extracellular role of HMGB1 in inflammation and sepsis.

31 March 2020

1 reference

Relevance of high-mobility group protein box 1 to neurodegeneration

31 March 2020

1 reference

Reversing established sepsis with antagonists of endogenous high-mobility group box 1.

31 March 2020

1 reference

HMG-1 as a mediator of acute lung inflammation

31 March 2020

1 reference

High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage

31 March 2020

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HMGB1 interacts with human topoisomerase IIalpha and stimulates its catalytic activity.

31 March 2020

1 reference

High mobility group box 1 protein interacts with multiple Toll-like receptors

31 March 2020

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HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.

31 March 2020

1 reference

Activation of gene expression in human neutrophils by high mobility group box 1 protein

31 March 2020

1 reference

Neurite growth-promoting protein (amphoterin, p30) binds syndecan

31 March 2020

1 reference

Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases

31 March 2020

1 reference

Selective proinflammatory activation of astrocytes by high-mobility group box 1 protein signaling

31 March 2020

1 reference

Interaction proteomics of the HMGA chromatin architectural factors.

31 March 2020

1 reference

Identification of new high mobility group A1 associated proteins.

31 March 2020

1 reference

The cytokine activity of HMGB1.

31 March 2020

1 reference

Cell cycle regulation of the glyceraldehyde-3-phosphate dehydrogenase/uracil DNA glycosylase gene in normal human cells

31 March 2020

1 reference

Proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase: a possible site of action of antiapoptotic drugs

31 March 2020

1 reference

Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: new perspectives on housekeepers

31 March 2020

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31 March 2020

Secretion without Golgi

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Exosomes: from biogenesis and secretion to biological function

31 March 2020

1 reference

Exosomes: endosomal-derived vesicles shipping extracellular messages

31 March 2020

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31 March 2020

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Rehearsing the ABCs. Protein translocation

31 March 2020

1 reference

A C-terminal signal prevents secretion of luminal ER proteins

31 March 2020

1 reference

Signal sequences. The limits of variation

31 March 2020

1 reference

Nuclear targeting sequences--a consensus?

31 March 2020

1 reference

Nuclear export signal consensus sequences defined using a localization-based yeast selection system

31 March 2020

1 reference

Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria.

31 March 2020

1 reference

Import of peroxisomal matrix and membrane proteins

31 March 2020

1 reference

Genomic organization and biosynthesis of secreted and cytoplasmic forms of gelsolin

31 March 2020

1 reference

Identification and characterization of mErk5-T, a novel Erk5/Bmk1 splice variant.

31 March 2020

1 reference

A rise in nuclear calcium translocates annexins IV and V to the nuclear envelope

31 March 2020

1 reference

Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members

31 March 2020

1 reference

Nonconventional trafficking of Ras associated with Ras signal organization

31 March 2020

1 reference

STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5.

31 March 2020

1 reference

Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway

31 March 2020

1 reference

Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors

31 March 2020

1 reference

RNA binding and phosphorylation determine the intracellular distribution of nuclear factors 90 and 110

31 March 2020

1 reference

An annexin 2 phosphorylation switch mediates p11-dependent translocation of annexin 2 to the cell surface

31 March 2020

1 reference

Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation

31 March 2020

1 reference

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

31 March 2020

1 reference

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

31 March 2020

1 reference

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

31 March 2020

1 reference

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

31 March 2020

1 reference

Nuclear access and action of notch in vivo

31 March 2020

1 reference

A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes

31 March 2020

1 reference

Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival

31 March 2020

1 reference

Extracellular proteome of human hepatoma cell, HepG2 analyzed using two-dimensional liquid chromatography coupled with tandem mass spectrometry.

31 March 2020

1 reference

A proteomic approach to characterize protein shedding

31 March 2020

1 reference

Identification of differentially secreted biomarkers using LC-MS/MS in isogenic cell lines representing a progression of breast cancer

31 March 2020

1 reference

The human plasma proteome: a nonredundant list developed by combination of four separate sources

31 March 2020

1 reference

The characterization of the invasion phenotype of uveal melanoma tumour cells shows the presence of MUC18 and HMG-1 metastasis markers and leads to the identification of DJ-1 as a potential serum biomarker

31 March 2020

1 reference

Human epididymal secretome and proteome

31 March 2020

1 reference

The proteome and secretome of human arterial smooth muscle cells

31 March 2020

1 reference

Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions

31 March 2020

1 reference

Toward a better analysis of secreted proteins: the example of the myeloid cells secretome

31 March 2020

1 reference

Two-dimensional maps and databases of the human macrophage proteome and secretome

31 March 2020

1 reference

Proteomic analysis of astrocytic secretion in the mouse. Comparison with the cerebrospinal fluid proteome.

31 March 2020

1 reference

Cancer cell-secreted proteomes as a basis for searching potential tumor markers: nasopharyngeal carcinoma as a model

31 March 2020

1 reference

Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles

31 March 2020

1 reference

ExPASy: The proteomics server for in-depth protein knowledge and analysis

31 March 2020

1 reference

PIGOK: Linking protein identity to gene ontology and function.

31 March 2020

1 reference

Annexin II is a major component of fusogenic endosomal vesicles

31 March 2020

1 reference

Annexin A2 binds to the localization signal in the 3′ untranslated region of c-myc mRNA

31 March 2020

1 reference

Annexin A2 is a novel RNA-binding protein

31 March 2020

1 reference

A major cellular substrate for protein kinases, annexin II, is a DNA-binding protein

31 March 2020

1 reference

Regulation of nucleo-cytoplasmic shuttling of human annexin A2: a proposed mechanism

31 March 2020

1 reference

Extracellular annexin II.

31 March 2020

1 reference

Active caspase-1 is a regulator of unconventional protein secretion

31 March 2020

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31 March 2020

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The ins and outs of calreticulin: from the ER lumen to the extracellular space.

31 March 2020

1 reference

The role of autocrine motility factor in tumor and tumor microenvironment

31 March 2020

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Calreticulin Is at the Surface of Circulating Neutrophils and Uses CD59 as an Adaptor Molecule

31 March 2020

1 reference

Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly

31 March 2020

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The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes

31 March 2020

1 reference

Cutting edge: extracellular high mobility group box-1 protein is a proangiogenic cytokine

31 March 2020

1 reference

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

31 March 2020

1 reference

Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification

31 March 2020

1 reference

The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway

31 March 2020

1 reference

Cyclophilin A is a proinflammatory cytokine that activates endothelial cells

31 March 2020

1 reference

The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function

31 March 2020

1 reference

Identification and characterization of triosephosphate isomerase that specifically interacts with the integrin alphaIIb cytoplasmic domain

31 March 2020

1 reference

ALDH3A1: a corneal crystallin with diverse functions

31 March 2020

1 reference

Updated biological roles for matrix metalloproteinases and new "intracellular" substrates revealed by degradomics

31 March 2020

1 reference

Control of the nuclear-cytoplasmic partitioning of annexin II by a nuclear export signal and by p11 binding

31 March 2020

1 reference

12 December 2020

Intracellular HMGB1 transactivates the human IL1B gene promoter through association with an Ets transcription factor PU.1.

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12 December 2020

Reversible dissociation of tetrameric rabbit muscle glyceraldehyde 3-phosphate dehydrogenase into dimers or monomers by adenosine triphosphate

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12 December 2020

Quantitative proteomics by stable isotope labeling and mass spectrometry

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12 December 2020

Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis

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12 December 2020

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

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12 December 2020

Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor

1 reference

12 December 2020

Profiling of the secreted proteins during 3T3-L1 adipocyte differentiation leads to the identification of novel adipokines

1 reference

12 December 2020

Ectopeptidases in tumour biology: a review

1 reference

12 December 2020

Regulation of cell migration by amphoterin.

1 reference

12 December 2020

Interactions of plasminogen and tissue plasminogen activator (t-PA) with amphoterin. Enhancement of t-PA-catalyzed plasminogen activation by amphoterin

1 reference

12 December 2020

The molecular chaperone calnexin is expressed on the surface of immature thymocytes in association with clonotype-independent CD3 complexes

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12 December 2020

Membrane microparticles: two sides of the coin

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12 December 2020

Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)

1 reference

12 December 2020

Ligand-specific, transient interaction between integrins and calreticulin during cell adhesion to extracellular matrix proteins is dependent upon phosphorylation/dephosphorylation events

1 reference

12 December 2020

Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses.

1 reference

12 December 2020

Amphoterin, the 30-kDa protein in a family of HMG1-type polypeptides. Enhanced expression in transformed cells, leading edge localization, and interactions with plasminogen activation

1 reference

12 December 2020

Extracellular roles for the molecular chaperone, hsp90.

1 reference

12 December 2020

Purification and characterization of phosphohexose isomerase from human gastrointestinal carcinoma and its potential relationship to neuroleukin

1 reference

12 December 2020

Purification and characterization of human T-lymphocyte-derived erythroid-potentiating activity

1 reference

12 December 2020

Association of glycolytic enzymes with the cytoskeleton

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12 December 2020

Urokinase plasminogen activator cleaves its cell surface receptor releasing the ligand-binding domain

1 reference

12 December 2020

Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide

1 reference

12 December 2020

Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha.

1 reference

12 December 2020

Calreticulin and calreticulin fragments are endothelial cell inhibitors that suppress tumor growth

1 reference

12 December 2020

Dilating the degradome: matrix metalloproteinase 2 (MMP-2) cuts to the heart of the matter

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD2945

1 reference

21 August 2017

1 reference

PubMed ID

19949400