(Q37691234)

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Tissue-specificity and ethnic diversity in obesity-related risk of cancer may be explained by variability in insulin response and insulin signaling pathways

scientific article published on 11 February 2010

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scholarly article

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Europe PubMed Central

22 August 2017

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Europe PubMed Central

Tissue-specificity and ethnic diversity in obesity-related risk of cancer may be explained by variability in insulin response and insulin signaling pathways (English)

1 reference

Europe PubMed Central

22 August 2017

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Michael I Goran

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Michael I Goran

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Europe PubMed Central

22 August 2017

author name string

John R Speakman

1

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Europe PubMed Central

22 August 2017

publication date

11 February 2010

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Europe PubMed Central

22 August 2017

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Europe PubMed Central

22 August 2017

18

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Europe PubMed Central

22 August 2017

6

1 reference

Europe PubMed Central

22 August 2017

1071-1078

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Europe PubMed Central

22 August 2017

Prevalence and Trends in Obesity Among US Adults, 1999-2000

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Prevalence of overweight and obesity in the United States, 1999-2004

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Increases in morbid obesity in the USA: 2000-2005

1 reference

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High body mass index for age among US children and adolescents, 2003-2006

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Prevalence of fatty liver in children and adolescents.

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Insights from the developing world: thrifty genotypes and thrifty phenotypes.

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Early influences on human energy regulation: thrifty genotypes and thrifty phenotypes

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A nonadaptive scenario explaining the genetic predisposition to obesity: the "predation release" hypothesis

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Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the 'drifty gene' hypothesis

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Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents

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Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction

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Contribution of insulin secretion and clearance to glucose-induced insulin concentration in african-american and caucasian children

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Insulin resistance and associated compensatory responses in african-american and Hispanic children

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Insulin signalling in the heart

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How insulin receptor substrate proteins regulate the metabolic capacity of the liver--implications for health and disease

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Modulation of insulin action.

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Alternative splicing of human insulin receptor messenger RNA.

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Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

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Signaling differences from the A and B isoforms of the insulin receptor (IR) in 32D cells in the presence or absence of IR substrate-1.

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21 January 2018

Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms

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Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: modulation by aging and differentiation in rat adipose tissue

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Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT

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Hormonal induction of adipogenesis induces Skp2 expression through PI3K and MAPK pathways

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Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells.

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p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells

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Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

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Introduction to NF-kappaB: players, pathways, perspectives

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The NF-kappaB regulatory network

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

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Defining the role of mTOR in cancer

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

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Disruption of IRS-2 causes type 2 diabetes in mice

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Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

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The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

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Brain IRS2 signaling coordinates life span and nutrient homeostasis

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Extended longevity in mice lacking the insulin receptor in adipose tissue

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Tumours with PI3K activation are resistant to dietary restriction

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Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

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The insulin receptor isoform exon 11- (IR-A) in cancer and other diseases: a review.

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The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer.

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Skp2 controls adipocyte proliferation during the development of obesity.

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Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer

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Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells

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PI3K/Akt signaling regulates p27(kip1) expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27(kip1) regulation in LNCaP and PC346 cells

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Clinical significance of p27 and Skp2 protein expression in uterine cervical neoplasm.

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Identifiers

10.1038/OBY.2010.16

1 reference

Europe PubMed Central

22 August 2017

1 reference

Europe PubMed Central

22 August 2017

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