(Q37691234)

English

Tissue-specificity and ethnic diversity in obesity-related risk of cancer may be explained by variability in insulin response and insulin signaling pathways

scientific article published on 11 February 2010

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

22 August 2017

1 reference

Europe PubMed Central

Tissue-specificity and ethnic diversity in obesity-related risk of cancer may be explained by variability in insulin response and insulin signaling pathways (English)

1 reference

Europe PubMed Central

PubMed publication ID

22 August 2017

0 references

1 reference

based on heuristic

inferred from title

Michael I Goran

2

object named as

Michael I Goran

1 reference

Europe PubMed Central

PubMed publication ID

22 August 2017

author name string

John R Speakman

1

1 reference

Europe PubMed Central

PubMed publication ID

22 August 2017

publication date

11 February 2010

1 reference

Europe PubMed Central

PubMed publication ID

22 August 2017

1 reference

Europe PubMed Central

PubMed publication ID

22 August 2017

18

1 reference

Europe PubMed Central

PubMed publication ID

22 August 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

22 August 2017

1071-1078

1 reference

Europe PubMed Central

PubMed publication ID

22 August 2017

Prevalence and Trends in Obesity Among US Adults, 1999-2000

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Prevalence of overweight and obesity in the United States, 1999-2004

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Increases in morbid obesity in the USA: 2000-2005

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

High body mass index for age among US children and adolescents, 2003-2006

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Prevalence of fatty liver in children and adolescents.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Stone agers in the fast lane: chronic degenerative diseases in evolutionary perspective

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Human obesity: an evolutionary approach to understanding our bulging waistline

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Eating, exercise, and "thrifty" genotypes: connecting the dots toward an evolutionary understanding of modern chronic diseases

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Insights from the developing world: thrifty genotypes and thrifty phenotypes.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Early influences on human energy regulation: thrifty genotypes and thrifty phenotypes

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

A history of obesity, or how what was good became ugly and then bad.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

The evolution of human fatness and susceptibility to obesity: an ethological approach.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Thrifty genes for obesity and the metabolic syndrome--time to call off the search?

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

A nonadaptive scenario explaining the genetic predisposition to obesity: the "predation release" hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the 'drifty gene' hypothesis

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Exploring the thrifty genotype's food-shortage assumptions: a cross-cultural comparison of ethnographic accounts of food security among foraging and agricultural societies.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

The multiethnic cohort study: exploring genes, lifestyle and cancer risk

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Nutrition, insulin, insulin-like growth factors and cancer

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Survival and disease patterns in C57BL/6J mice subjected to undernutrition.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Rapid and reversible induction of the longevity, anticancer and genomic effects of caloric restriction

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Contribution of insulin secretion and clearance to glucose-induced insulin concentration in african-american and caucasian children

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Insulin resistance and associated compensatory responses in african-american and Hispanic children

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Insulin signalling in the heart

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

How insulin receptor substrate proteins regulate the metabolic capacity of the liver--implications for health and disease

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Modulation of insulin action.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Alternative splicing of human insulin receptor messenger RNA.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Signaling differences from the A and B isoforms of the insulin receptor (IR) in 32D cells in the presence or absence of IR substrate-1.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: modulation by aging and differentiation in rat adipose tissue

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Hormonal induction of adipogenesis induces Skp2 expression through PI3K and MAPK pathways

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Phosphoinositide-3-kinase signaling controls S-phase kinase-associated protein 2 transcription via E2F1 in pancreatic ductal adenocarcinoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

p27 Kip1 nuclear localization and cyclin-dependent kinase inhibitory activity are regulated by glycogen synthase kinase-3 in human colon cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Introduction to NF-kappaB: players, pathways, perspectives

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

The NF-kappaB regulatory network

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Defining the role of mTOR in cancer

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

The role of insulin receptor substrate 2 in hypothalamic and beta cell function.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Brain IRS2 signaling coordinates life span and nutrient homeostasis

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Extended longevity in mice lacking the insulin receptor in adipose tissue

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Reduced susceptibility of muscle-specific insulin receptor knockout mice to colon carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

PTEN: life as a tumor suppressor

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Tumours with PI3K activation are resistant to dietary restriction

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

The insulin receptor isoform exon 11- (IR-A) in cancer and other diseases: a review.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Skp2 controls adipocyte proliferation during the development of obesity.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

PI3K/Akt signaling regulates p27(kip1) expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27(kip1) regulation in LNCaP and PC346 cells

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Clinical significance of p27 and Skp2 protein expression in uterine cervical neoplasm.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Significance of skp2 expression in primary breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Skp2 suppresses p53-dependent apoptosis by inhibiting p300.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Deathproof: new insights on the role of skp2 in tumorigenesis.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Body mass index, circulating levels of sex-steroid hormones, IGF-I and IGF-binding protein-3: a cross-sectional study in healthy women

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Insulin-like growth factor-I is inversely related to adiposity in overweight Latino children.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Insulin-like growth factor type I receptor gene expression and obesity in esophageal adenocarcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Body mass index, waist circumference and waist–hip ratio and serum levels of IGF-I and IGFBP-3 in European women

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

21 January 2018

Trends in overweight and obesity prevalence in Chilean children: comparison of three definitions

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

A comparison of national estimates of obesity prevalence from the behavioral risk factor surveillance system and the National Health and Nutrition Examination Survey

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Child overweight and obesity in the USA: prevalence rates according to IOTF definitions

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Health implications of obesity

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Medical hazards of obesity

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Cardiovascular morbidity and mortality associated with the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Tumor Incidence Patterns and Nutrition in the Rat

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Relation of body fat distribution to hyperinsulinemia in children and adolescents: the Bogalusa Heart Study.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Fat distribution and insulin response in prepubertal African American and white children

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Racial differences in insulin secretion and sensitivity in prepubertal children: role of physical fitness and physical activity

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Dissecting the role of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) signalling pathways.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Expression of the ubiquitin ligase subunit cyclin kinase subunit 1 and its relationship to S-phase kinase protein 2 and p27Kip1 in prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Single and joint effects of pesticides and mercury on soil urease

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Relationships between IGF-I and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency.

1 reference

https://api.crossref.org/works/10.1038%2FOBY.2010.16

31 March 2020

Identifiers

10.1038/OBY.2010.16

1 reference

Europe PubMed Central

PubMed publication ID

22 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

22 August 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q37691234&oldid=2221890463"