(Q37744878)

22 August 2017

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title

Targeting tau protein in Alzheimer's disease (English)

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22 August 2017

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2

Inge Grundke-Iqbal

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22 August 2017

1

Cheng-Xin Gong

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22 August 2017

Khalid Iqbal

3

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22 August 2017

1 May 2010

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22 August 2017

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22 August 2017

27

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22 August 2017

5

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22 August 2017

351-365

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https://scigraph.springernature.com/pub.10.2165/11536110-000000000-00000

22 August 2017

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cites work

Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains

1 reference

https://api.crossref.org/works/10.2165%2F11536110-000000000-00000

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11536110-000000000-00000

Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11536110-000000000-00000

Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11536110-000000000-00000

Cyclin-dependent kinase inhibitors attenuate protein hyperphosphorylation, cytoskeletal lesion formation, and motor defects in Niemann-Pick Type C mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11536110-000000000-00000

Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11536110-000000000-00000

Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11536110-000000000-00000

Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins--a role in nuclear localization

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11536110-000000000-00000

Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11536110-000000000-00000

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11536110-000000000-00000

Expression of heat shock proteins in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11536110-000000000-00000

Controversies over p25 in Alzheimer's disease.

21 January 2018

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12 December 2020

Mechanisms of tau-induced neurodegeneration

1 reference

12 December 2020

Lithium induces autophagy by inhibiting inositol monophosphatase

1 reference

12 December 2020

A gene expression profile of Alzheimer's disease

1 reference

12 December 2020

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1 reference

12 December 2020

Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A.

1 reference

12 December 2020

Autophagy in neurodegenerative disease: friend, foe or turncoat?

1 reference

12 December 2020

Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques

1 reference

12 December 2020

Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques

1 reference

12 December 2020

Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies.

1 reference

12 December 2020

Neurons may live for decades with neurofibrillary tangles.

1 reference

12 December 2020

Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications

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12 December 2020

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

1 reference

12 December 2020

Global prevalence of dementia: a Delphi consensus study

1 reference

12 December 2020

Neurobiology: p25 protein in neurodegeneration

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12 December 2020

Granular tau oligomers as intermediates of tau filaments

1 reference

12 December 2020

Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease

1 reference

12 December 2020

Alzheimer's disease: the amyloid cascade hypothesis

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells

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12 December 2020

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

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12 December 2020

Impaired proteasome function in Alzheimer's disease

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12 December 2020

Troglitazone, a peroxisome proliferator-activated receptor-gamma agonist, decreases tau phosphorylation in CHOtau4R cells.

1 reference

12 December 2020

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

1 reference

12 December 2020

Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

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12 December 2020

Increased synthesis and accumulation of heat shock 70 proteins in Alzheimer's disease.

1 reference

12 December 2020

Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles

1 reference

12 December 2020

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

1 reference

12 December 2020

GSK-3: a key player in neurodegeneration and memory.

1 reference

12 December 2020

Phosphorylation affects the ability of tau protein to promote microtubule assembly.

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12 December 2020

Post-translational modifications of tau protein in Alzheimer's disease

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12 December 2020

GSK3 inhibitors: development and therapeutic potential

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12 December 2020

Glycogen synthase kinase-3beta, or a link between amyloid and tau pathology?

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12 December 2020

Promotion of hyperphosphorylation by frontotemporal dementia tau mutations

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12 December 2020

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity

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12 December 2020

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

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12 December 2020

Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.

1 reference

12 December 2020

Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert.

1 reference

12 December 2020

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

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12 December 2020

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

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12 December 2020

Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

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12 December 2020

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

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12 December 2020

Observations on the brains of demented old people

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12 December 2020

Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A.

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12 December 2020

GSK-3 inhibitors for Alzheimer's disease.

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12 December 2020

O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors.

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12 December 2020

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

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12 December 2020

Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting.

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12 December 2020

Protein phosphatase 2A is the major enzyme in brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase

1 reference

12 December 2020

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

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12 December 2020

The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A

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12 December 2020

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

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12 December 2020

Pharmacological inhibitors of glycogen synthase kinase 3.

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12 December 2020

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

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12 December 2020

Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly

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12 December 2020

PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus

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12 December 2020

Structure-based approaches in the design of GSK-3 selective inhibitors.

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12 December 2020

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

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12 December 2020

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation

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12 December 2020

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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12 December 2020

A pool of beta-tubulin is hyperphosphorylated at serine residues in Alzheimer disease brain

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12 December 2020

Assembly of two distinct dimers and higher-order oligomers from full-length tau.

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12 December 2020

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

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12 December 2020

The potential role of tau protein O-glycosylation in Alzheimer's disease

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12 December 2020

Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis

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12 December 2020

Chaperone-like antibodies targeting misfolded tau protein: new vistas in the immunotherapy of neurodegenerative foldopathies

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12 December 2020

Melatonin attenuates isoproterenol-induced protein kinase A overactivation and tau hyperphosphorylation in rat brain.

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12 December 2020

Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

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12 December 2020

Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51

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12 December 2020

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes.

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12 December 2020

Melatonin protects SH-SY5Y neuroblastoma cells from calyculin A-induced neurofilament impairment and neurotoxicity

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12 December 2020

Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers.

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12 December 2020

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease

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12 December 2020

Pharmacological inhibitors of cyclin-dependent kinases

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12 December 2020

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

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12 December 2020

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles.

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12 December 2020

Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease.

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12 December 2020

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

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12 December 2020

Phosphoprotein phosphatase activities in Alzheimer disease brain

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12 December 2020

Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases.

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12 December 2020

Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo.

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12 December 2020

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

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12 December 2020

Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening

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12 December 2020

Reduction of phosphorylated tau during memantine treatment of Alzheimer's disease.

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12 December 2020

Rapamycin alleviates toxicity of different aggregate-prone proteins

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12 December 2020

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

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12 December 2020

A protein factor essential for microtubule assembly

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12 December 2020

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

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12 December 2020

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

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12 December 2020

Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model.

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12 December 2020

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

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12 December 2020

Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains.

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12 December 2020

HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites

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12 December 2020

Defective brain microtubule assembly in Alzheimer's disease

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12 December 2020

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

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12 December 2020

Extracellular tau is toxic to neuronal cells.

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12 December 2020

Effect of inhibiting melatonin biosynthesis on spatial memory retention and tau phosphorylation in rat.

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12 December 2020

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

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12 December 2020

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

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12 December 2020

Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease

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12 December 2020

Effect of melatonin on calyculin A-induced tau hyperphosphorylation.

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12 December 2020

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

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12 December 2020

Stratification of patients is the way to go to develop neuroprotective/disease-modifying drugs for Alzheimer's disease

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12 December 2020

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

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12 December 2020

Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine.

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12 December 2020

Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5.

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12 December 2020

Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

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12 December 2020

Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies.

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12 December 2020

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

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12 December 2020

Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

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12 December 2020

Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies

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12 December 2020

Tissue distribution, pharmacokinetics and identification of roscovitine metabolites in rat.

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12 December 2020

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

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12 December 2020

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

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12 December 2020

Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients.

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12 December 2020

Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau.

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12 December 2020

Tau suppression in a neurodegenerative mouse model improves memory function

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12 December 2020

Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation.

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12 December 2020

Molecular targets of lithium action

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12 December 2020

Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases

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12 December 2020

GSK-3 is essential in the pathogenesis of Alzheimer's disease.

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12 December 2020

Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

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12 December 2020

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

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12 December 2020

Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells

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12 December 2020

Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.

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12 December 2020

The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine

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12 December 2020

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy

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12 December 2020

Identification of normal and pathological aging in prospectively studied nondemented elderly humans

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12 December 2020

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

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12 December 2020

Tau is a candidate gene for chromosome 17 frontotemporal dementia

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12 December 2020

Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration

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12 December 2020

Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study.

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12 December 2020

Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells

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12 December 2020

Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

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12 December 2020

Tau therapeutic strategies for the treatment of Alzheimer's disease

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12 December 2020

Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation.

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12 December 2020

10.2165/11536110-000000000-00000

Identifiers

DOI

1 reference

PubMed ID

20450234

Dimensions Publication ID

22 August 2017

0 references

1 reference

PubMed ID

20450234