(Q38042382)

27 August 2017

title

The chemical biology of phosphoinositide 3-kinases (English)

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27 August 2017

Matthias P Wymann

1

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27 August 2017

Carsten Schultz

series ordinal

2

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27 August 2017

publication date

10 September 2012

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27 August 2017

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27 August 2017

volume

13

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27 August 2017

issue

14

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27 August 2017

page(s)

2022-2035

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Lipid signalling in disease.

27 August 2017

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Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

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The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond

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PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody

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Divide and ProsPer: the emerging role of PtdIns3P in cytokinesis.

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Phosphatidylinositol 4-kinases: old enzymes with emerging functions

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Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function

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The role of SHIP in cytokine-induced signaling

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Implication of phosphoinositide phosphatases in genetic diseases: the case of myotubularin

21 January 2018

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Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1.

21 January 2018

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Coordination of Golgi functions by phosphatidylinositol 4-kinases

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Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes.

21 January 2018

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Movin' on up: the role of PtdIns(4,5)P(2) in cell migration.

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The myotubularin family: from genetic disease to phosphoinositide metabolism

21 January 2018

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The myotubularin family of lipid phosphatases in disease and in spermatogenesis

21 January 2018

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Phosphoinositides in cell regulation and membrane dynamics

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Mammalian phosphoinositide kinases and phosphatases

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Phosphoinositide signalling in cancer: beyond PI3K and PTEN.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Lipids on the move: phosphoinositide 3-kinases in leukocyte function

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Phosphoinositide 3-kinase in disease: timing, location, and scaffolding

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Taming the PI3K team to hold inflammation and cancer at bay.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Targeting phosphoinositide 3-kinase: moving towards therapy

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

PI3Ks-drug targets in inflammation and cancer.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

21 January 2018

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Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase

21 January 2018

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Structure, regulation and function of PKB/AKT--a major therapeutic target

21 January 2018

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PIKKing on PKB: regulation of PKB activity by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

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Inositol trisphosphate, a novel second messenger in cellular signal transduction

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

21 January 2018

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Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Inositol lipid-dependent functions in Saccharomyces cerevisiae: analysis of phosphatidylinositol phosphates

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Visualizing cellular phosphoinositide pools with GFP-fused protein-modules

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Selective cellular effects of overexpressed pleckstrin-homology domains that recognize PtdIns(3,4,5)P3 suggest their interaction with protein binding partners.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Inositol-lipid binding motifs: signal integrators through protein-lipid and protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Membrane targeting and remodeling through phosphoinositide-binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

BAR, F-BAR (EFC) and ENTH/ANTH domains in the regulation of membrane-cytosol interfaces and membrane curvature

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

A new evaluation method for quantifying PI3K activity by HTRF assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

A monoclonal antibody to visualize PtdIns(3,4,5)P(3) in cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2).

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Production of PtdInsP3 at endomembranes is triggered by receptor endocytosis

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activity

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Semisynthesis of fluorescent metabolite sensors on cell surfaces

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Selective fluorescence labeling of lipids in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).

21 January 2018

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Characterisation of the PTEN inhibitor VO-OHpic

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Inhibitor and activator: dual functions for SHIP in immunity and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Inositol polyphosphates, diphosphoinositol polyphosphates and phosphatidylinositol polyphosphate lipids: structure, synthesis, and development of probes for studying biological activity

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Synthesis of unsaturated phosphatidylinositol 4,5-bisphosphate and analogues.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Phosphoinositide signaling; from affinity probes to pharmaceutical targets

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Metabolically stabilized derivatives of phosphatidylinositol 4-phosphate: synthesis and applications.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Labelling peptides with fluorescent probes for incorporation into degradable polymers

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Balpha

21 January 2018

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Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Orthogonal protecting groups for N(alpha)-amino and C-terminal carboxyl functions in solid-phase peptide synthesis

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Membrane-Permeant Phosphoinositide Derivatives as Modulators of Growth Factor Signaling and Neurite Outgrowth

21 January 2018

1 reference

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Synthesis of hybrid lipid probes: derivatives of phosphatidylethanolamine-extended phosphatidylinositol 4,5-bisphosphate (Pea-PIP(2)).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Development of carbohydrate-derived inhibitors of acid sphingomyelinase.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

A Chemical Proteomics Approach to Phosphatidylinositol 3-Kinase Signaling in Macrophages

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Antagonists of myo-inositol 3,4,5,6-tetrakisphosphate allow repeated epithelial chloride secretion

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Membrane-permeant esters of phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells

21 January 2018

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Intracellular delivery of phosphoinositides and inositol phosphates using polyamine carriers

21 January 2018

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Highly Efficient and Ultrafast Phototriggers for cAMP and cGMP by Using Long-Wavelength UV/Vis-Activation This work was supported by the Deutsche Forschungsgemeinschaft, the European Union, and the Fonds der Chemischen Industrie. We thank B. Dekowsk

21 January 2018

1 reference

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Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis

21 January 2018

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Photoactivatable and cell-membrane-permeable phosphatidylinositol 3,4,5-trisphosphate.

21 January 2018

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Controlling Signal Transduction with Synthetic Ligands

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

A versatile synthetic dimerizer for the regulation of protein-protein interactions

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Rapidly inducible changes in phosphatidylinositol 4,5-bisphosphate levels influence multiple regulatory functions of the lipid in intact living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Dual regulation of TRPV1 by phosphoinositides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

An inducible translocation strategy to rapidly activate and inhibit small GTPase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Synthetic activation of endogenous PI3K and Rac identifies an AND-gate switch for cell polarization and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Characterization of the FKBP.rapamycin.FRB ternary complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Switching heterotrimeric G protein subunits with a chemical dimerizer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Selective cross-linking of interacting proteins using self-labeling tags

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Light regulation of protein dimerization and kinase activity in living cells using photocaged rapamycin and engineered FKBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

PI 3-kinase p110beta: a new target for antithrombotic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Key role of phosphoinositide 3-kinase class IB in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

PI3K/p110{delta} is a novel therapeutic target in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Vertical targeting of the phosphatidylinositol-3 kinase pathway as a strategy for treating melanoma

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201200089

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39.

21 January 2018

1 reference

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Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors.

21 January 2018

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Advances in development of phosphatidylinositol 3-kinase inhibitors

21 January 2018

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Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Synthesis of thiophosphate analogues of DL-myo-inositol 1.2-Cyclic phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Membrane-permeant esters of inositol polyphosphates, chemical syntheses and biological applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

Controlling Protein Function by Caged Compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

A FlAsH-Based Cross-Linker to Study Protein Interactions in Living Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

A non-disruptive technique for loading calcium buffers and indicators into cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200089

21 January 2018

Identifiers

DOI

10.1002/CBIC.201200089

1 reference

27 August 2017

1 reference