(Q38046794)

27 August 2017

Epigenetic alterations in hematopoietic malignancies (English)

1 reference

27 August 2017

3

1 reference

27 August 2017

Young Rock Chung

1

1 reference

PubMed ID

23015417

27 August 2017

Emma Schatoff

series ordinal

2

1 reference

27 August 2017

27 September 2012

1 reference

International Journal of Hematology

27 August 2017

1 reference

27 August 2017

96

1 reference

27 August 2017

413-427

1 reference

27 August 2017

4

1 reference

https://scigraph.springernature.com/pub.10.1007/s12185-012-1181-z

27 August 2017

0 references

cites work

MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Aberrant DNA methylation is a dominant mechanism in MDS progression to AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

CREBBP mutations in relapsed acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Clinical effect of point mutations in myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

A gene complex controlling segmentation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

The Polycomb complex PRC2 and its mark in life

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

EZH2 mutational status predicts poor survival in myelofibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Polycomb group protein enhancer of zeste 2 is an oncogene that promotes the neoplastic transformation of a benign prostatic epithelial cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Activation of the enhancer of zeste homologue 2 gene by the human papillomavirus E7 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Loss of the tumor suppressor BAP1 causes myeloid transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

A chromatin landmark and transcription initiation at most promoters in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

An epigenetic road map for histone lysine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

hDOT1L links histone methylation to leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

MLL translocations, histone modifications and leukaemia stem-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Common mechanism for oncogenic activation of MLL by forkhead family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

An RNA polymerase II elongation factor encoded by the human ELL gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Mll partial tandem duplication induces aberrant Hox expression in vivo via specific epigenetic alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

The super elongation complex (SEC) and MLL in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Selective inhibition of BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Suppression of inflammation by a synthetic histone mimic

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Analysis of the coding genome of diffuse large B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Is histone acetylation the most important physiological function for CBP and p300?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Tumors in Rubinstein-Taybi syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Type I MOZ/CBP (MYST3/CREBBP) is the most common chimeric transcript in acute myeloid leukemia with t(8;16)(p11;p13) translocation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

DNA methylation and the regulation of gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

DNMT3A Mutations in Acute Myeloid Leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Array-based genomic resequencing of human leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Dnmt3a is essential for hematopoietic stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Mutation in TET2 in myeloid cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

TET family proteins and their role in stem cell differentiation and transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

The role of mutations in epigenetic regulators in myeloid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Recurring mutations found by sequencing an acute myeloid leukemia genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Human PAD4 regulates histone arginine methylation levels via demethylimination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12185-012-1181-Z

Fatigue strength of locking screws and prototypes used in small-diameter tibial nails: a biomechanical study

21 January 2018

1 reference

12 December 2020

MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice

1 reference

12 December 2020

Rearrangement of ALL1 (MLL) in acute myeloid leukemia with normal cytogenetics

1 reference

12 December 2020

A role for DOT1L inMLL-rearranged leukemias

1 reference

12 December 2020

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP

1 reference

12 December 2020

Acute monocytic leukemia with (8;22)(p11;q13) translocation. Involvement of 8p11 as in classical t(8;16)(p11;p13)

1 reference

12 December 2020

Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.

1 reference

12 December 2020

Molecular rearrangement of the ALL-1 gene in acute myeloid leukemia without cytogenetic evidence of 11q23 chromosomal translocations

1 reference

12 December 2020

TET2 and DNMT3A mutations in human T-cell lymphoma

1 reference

12 December 2020

A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.

1 reference

12 December 2020

A687V EZH2 is a gain-of-function mutation found in lymphoma patients

1 reference

12 December 2020

10.1007/S12185-012-1181-Z

Identifiers

DOI

1 reference

PubMed ID

23015417

Dimensions Publication ID

27 August 2017

0 references

1 reference

PubMed ID

23015417