(Q38109928)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23713780%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Druggable orthosteric and allosteric hot spots to target protein-protein interactions (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23713780%20AND%20SRC:MED&resulttype=core&format=json

protein-protein interaction

2 March 2020

main subject

1 reference

2

Ruth Nussinov

2 references

PubMed publication ID

23713780

29 August 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23713780%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1

Buyong Ma

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23713780%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

publication date

1 January 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23713780%20AND%20SRC:MED&resulttype=core&format=json

Current Pharmaceutical Design

2 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23713780%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

volume

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23713780%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23713780%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

page(s)

1293-1301

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23713780%20AND%20SRC:MED&resulttype=core&format=json

An Eph receptor regulates integrin activity through R-Ras

2 March 2020

cites work

1 reference

12 December 2020

Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway

1 reference

12 December 2020

Protein functional epitopes: hot spots, dynamics and combinatorial libraries

1 reference

12 December 2020

An ephrin mimetic peptide that selectively targets the EphA2 receptor

1 reference

12 December 2020

Protein modules and protein-protein interaction. Introduction

1 reference

12 December 2020

Protein-protein interactions: structurally conserved residues distinguish between binding sites and exposed protein surfaces

1 reference

12 December 2020

Targeting the EphA4 receptor in the nervous system with biologically active peptides

1 reference

12 December 2020

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

1 reference

12 December 2020

Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins

1 reference

12 December 2020

Anchor residues in protein-protein interactions

1 reference

12 December 2020

Is allostery an intrinsic property of all dynamic proteins?

1 reference

12 December 2020

Protein-protein interactions: hot spots and structurally conserved residues often locate in complemented pockets that pre-organized in the unbound states: implications for docking

1 reference

12 December 2020

The role of ephrins and Eph receptors in cancer

1 reference

12 December 2020

Small-world network approach to identify key residues in protein-protein interaction

1 reference

12 December 2020

The modular architecture of protein-protein binding interfaces

1 reference

12 December 2020

Hot regions in protein--protein interactions: the organization and contribution of structurally conserved hot spot residues

1 reference

12 December 2020

Inhibiting protein-protein interactions using designed molecules

1 reference

12 December 2020

Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery

1 reference

12 December 2020

Design and structure of peptide and peptidomimetic antagonists of protein-protein interaction.

1 reference

12 December 2020

Disruption of protein-protein interactions: towards new targets for chemotherapy

1 reference

12 December 2020

Strategies for targeting protein-protein interactions with synthetic agents.

1 reference

12 December 2020

Protein-protein interactions in human disease

1 reference

12 December 2020

1 reference

12 December 2020

EphB2/R-Ras signaling regulates glioma cell adhesion, growth, and invasion

1 reference

12 December 2020

Protein-protein interactions: organization, cooperativity and mapping in a bottom-up Systems Biology approach

1 reference

12 December 2020

The contribution of the Trp/Met/Phe residues to physical interactions of p53 with cellular proteins

1 reference

12 December 2020

Targeting protein-protein interactions for cancer therapy

1 reference

12 December 2020

Oligomeric protein structure networks: insights into protein-protein interactions

1 reference

12 December 2020

Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity

1 reference

12 December 2020

Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion

1 reference

12 December 2020

Inhibition of protein-protein interactions: The discovery of druglike β-catenin inhibitors by combining virtual and biophysical screening

1 reference

12 December 2020

A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor

1 reference

12 December 2020

Markov propagation of allosteric effects in biomolecular systems: application to GroEL-GroES.

1 reference

12 December 2020

Hot-spot mimicry of a cytokine receptor by a small molecule

1 reference

12 December 2020

Binding hot spots in the TEM1-BLIP interface in light of its modular architecture

1 reference

12 December 2020

Strategies to search and design stabilizers of protein-protein interactions: a feasibility study

1 reference

12 December 2020

Hot spots--a review of the protein-protein interface determinant amino-acid residues

1 reference

12 December 2020

Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?

1 reference

12 December 2020

Three-dimensional Structure of the EphB2 Receptor in Complex with an Antagonistic Peptide Reveals a Novel Mode of Inhibition

1 reference

12 December 2020

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

1 reference

12 December 2020

Allostery: absence of a change in shape does not imply that allostery is not at play

1 reference

12 December 2020

Principles of protein-protein interactions: what are the preferred ways for proteins to interact?

1 reference

12 December 2020

KFC Server: interactive forecasting of protein interaction hot spots.

1 reference

12 December 2020

Allostery and cooperativity revisited

1 reference

12 December 2020

Understanding mechanisms governing protein-protein interactions from synthetic binding interfaces

1 reference

12 December 2020

Screening Outside the Catalytic Site: Inhibition of Macromolecular Inter-actions Through Structure-Based Virtual Ligand Screening Experiments.

1 reference

12 December 2020

Predicting druggable binding sites at the protein-protein interface.

1 reference

12 December 2020

Eph receptors and Ephrins in cancer: common themes and controversies.

1 reference

12 December 2020

Energetic determinants of protein binding specificity: insights into protein interaction networks

1 reference

12 December 2020

A feature-based approach to modeling protein-protein interaction hot spots.

1 reference

12 December 2020

Binding site detection and druggability index from first principles.

1 reference

12 December 2020

Allosteric transitions in biological nanomachines are described by robust normal modes of elastic networks

1 reference

12 December 2020

Identification of computational hot spots in protein interfaces: combining solvent accessibility and inter-residue potentials improves the accuracy.

1 reference

12 December 2020

1 reference

12 December 2020

Blinded by the Light: The Growing Complexity of p53

1 reference

12 December 2020

Early changes in hippocampal Eph receptors precede the onset of memory decline in mouse models of Alzheimer's disease.

1 reference

12 December 2020

The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions

1 reference

12 December 2020

Towards inferring time dimensionality in protein-protein interaction networks by integrating structures: the p53 example

1 reference

12 December 2020

Probing hot spots on protein-protein interfaces with all-atom free-energy simulation.

1 reference

12 December 2020

Assessing the druggability of protein-protein interactions by a supervised machine-learning method

1 reference

12 December 2020

Allosteric inhibition of human porphobilinogen synthase

1 reference

12 December 2020

One billion years of p53/p63/p73 evolution

1 reference

12 December 2020

Prediction of hot spot residues at protein-protein interfaces by combining machine learning and energy-based methods

1 reference

12 December 2020

RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways

1 reference

12 December 2020

Awakening guardian angels: drugging the p53 pathway

1 reference

12 December 2020

Rationalizing the chemical space of protein-protein interaction inhibitors

1 reference

12 December 2020

The scaffold protein Shoc2/SUR-8 accelerates the interaction of Ras and Raf.

1 reference

12 December 2020

Identification and characterization of a peptidic ligand for Ras.

1 reference

12 December 2020

Ligand detection in the allosteric world

1 reference

12 December 2020

Anti-EphA2 Antibodies with Distinct In Vitro Properties Have Equal In Vivo Efficacy in Pancreatic Cancer

1 reference

12 December 2020

Eph receptors and ephrins in cancer: bidirectional signalling and beyond

1 reference

12 December 2020

Allosteric modulation of Ras positions Q61 for a direct role in catalysis

1 reference

12 December 2020

Restriction of receptor movement alters cellular response: physical force sensing by EphA2.

1 reference

12 December 2020

Binding of anti-Parkinson's disease drugs to human serum albumin is allosterically modulated

1 reference

12 December 2020

Assessing the structural conservation of protein pockets to study functional and allosteric sites: implications for drug discovery

1 reference

12 December 2020

What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf

1 reference

12 December 2020

Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

1 reference

12 December 2020

HotPoint: hot spot prediction server for protein interfaces

1 reference

12 December 2020

Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

1 reference

12 December 2020

ANCHOR: a web server and database for analysis of protein-protein interaction binding pockets for drug discovery

1 reference

12 December 2020

Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach

1 reference

12 December 2020

ABC proteins in antigen translocation and viral inhibition

1 reference

12 December 2020

Structure-activity relationship analysis of peptides targeting the EphA2 receptor

1 reference

12 December 2020

Constraining binding hot spots: NMR and molecular dynamics simulations provide a structural explanation for enthalpy-entropy compensation in SH2-ligand binding

1 reference

12 December 2020

Presaging Critical Residues in Protein interfaces-Web Server (PCRPi-W): A Web Server to Chart Hot Spots in Protein Interfaces

1 reference

12 December 2020

Ephrins and Eph receptors in stem cells and cancer

1 reference

12 December 2020

Emerging principles in protease-based drug discovery

1 reference

12 December 2020

Conformational ensembles, signal transduction and residue hot spots: application to drug discovery.

1 reference

12 December 2020

The minor binding pocket: a major player in 7TM receptor activation

1 reference

12 December 2020

Allostery and population shift in drug discovery

1 reference

12 December 2020

Prediction of protein interaction hot spots using rough set-based multiple criteria linear programming.

1 reference

12 December 2020

Exploring and exploiting allostery: Models, evolution, and drug targeting

1 reference

12 December 2020

Of Ephs and ephrins: companies target guidance molecules in cancer.

1 reference

12 December 2020

Protein binding specificity versus promiscuity.

1 reference

12 December 2020

Relation between the conformational heterogeneity and reaction cycle of Ras: molecular simulation of Ras.

1 reference

12 December 2020

Receptor tyrosine kinases and their activation in melanoma.

1 reference

12 December 2020

Multiple-targeting and conformational selection in the estrogen receptor: computation and experiment

1 reference

12 December 2020

Ras history: The saga continues

1 reference

12 December 2020

Structural conservation of druggable hot spots in protein-protein interfaces

1 reference

12 December 2020

Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody

1 reference

12 December 2020

Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers

1 reference

12 December 2020

Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

1 reference

12 December 2020

Inhibition of Ras for cancer treatment: the search continues

1 reference

12 December 2020

Targeting Eph receptors with peptides and small molecules: progress and challenges

1 reference

12 December 2020

Structural biology and drug discovery of difficult targets: the limits of ligandability

1 reference

12 December 2020

The different ways through which specificity works in orthosteric and allosteric drugs

1 reference

12 December 2020

Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth

1 reference

12 December 2020

Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor

1 reference

12 December 2020

EphB4 promotes or suppresses Ras/MEK/ERK pathway in a context-dependent manner: Implications for EphB4 as a cancer target

1 reference

12 December 2020

A comprehensive survey of Ras mutations in cancer

1 reference

12 December 2020

Shift in the equilibrium between on and off states of the allosteric switch in Ras-GppNHp affected by small molecules and bulk solvent composition

1 reference

12 December 2020

Eph receptors and ephrins as targets for cancer therapy

1 reference

12 December 2020

A new dimension to Ras function: a novel role for nucleotide-free Ras in Class II phosphatidylinositol 3-kinase beta (PI3KC2β) regulation

1 reference

12 December 2020

Design, synthesis and characterization of novel small molecular inhibitors of ephrin-B2 binding to EphB4.

1 reference

12 December 2020

The underappreciated role of allostery in the cellular network.

1 reference

12 December 2020

A novel putative tyrosine kinase receptor encoded by the eph gene

1 reference

12 December 2020

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

1 reference

12 December 2020

Anatomy of hot spots in protein interfaces

1 reference

12 December 2020

10.2174/13816128113199990073

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23713780%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23713780%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

PubMed publication ID

23713780

1 reference