(Q38209606)

31 August 2017

title

PIM kinases: an overview in tumors and recent advances in pancreatic cancer (English)

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31 August 2017

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Jianwei Xu

1

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31 August 2017

Taiping Zhang

2

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31 August 2017

Tianxiao Wang

3

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31 August 2017

Lei You

4

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31 August 2017

Yupei Zhao

5

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31 August 2017

language of work or name

English

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publication date

1 April 2014

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31 August 2017

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31 August 2017

volume

10

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31 August 2017

issue

5

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31 August 2017

page(s)

865-876

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31 August 2017

cites work

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The PIM kinases in hematological cancers

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Roles of Pim-3, a novel survival kinase, in tumorigenesis

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The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

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Pim kinases in cancer: diagnostic, prognostic and treatment opportunities

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PIM1 kinase as a target for cancer therapy

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Seizure activity induces PIM-1 expression in brain

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Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP.

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The serine/threonine kinase Pim-1

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PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma.

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Growth and survival mechanisms associated with perineural invasion in prostate cancer

21 January 2018

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PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins

21 January 2018

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Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines.

21 January 2018

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Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines

21 January 2018

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Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression

21 January 2018

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Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations

21 January 2018

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Increased expression of the hPim-2 gene in human chronic lymphocytic leukemia and non-Hodgkin lymphoma

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Decreased levels of circulating and tissue miR-107 in human esophageal cancer.

21 January 2018

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

21 January 2018

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Delineation of prognostic biomarkers in prostate cancer

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The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias

21 January 2018

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Overexpression of Pim-1 in bladder cancer

21 January 2018

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Pim-1 kinase expression predicts radiation response in squamocellular carcinoma of head and neck and is under the control of epidermal growth factor receptor.

21 January 2018

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CD40 signaling in B cells regulates the expression of the Pim-1 kinase via the NF-kappa B pathway

21 January 2018

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Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation

21 January 2018

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EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.

21 January 2018

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RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation

21 January 2018

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The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells

21 January 2018

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ZFP36 expression impairs glioblastoma cell lines viability and invasiveness by targeting multiple signal transduction pathways

21 January 2018

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Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells.

21 January 2018

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MicroRNA-16 is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1.

21 January 2018

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The proto-oncogene Pim-1 is a target of miR-33a

21 January 2018

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Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation

21 January 2018

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miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts

21 January 2018

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Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells.

21 January 2018

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The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Pim-1 kinase and p100 cooperate to enhance c-Myb activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Activation of cell cycle arrest and apoptosis by the proto-oncogene Pim-2.

21 January 2018

1 reference

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Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Elevated levels of oncogenic protein kinase Pim-1 induce the p53 pathway in cultured cells and correlate with increased Mdm2 in mantle cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

mTOR signaling at a glance

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

The Pim protein kinases regulate energy metabolism and cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Autophagy modulation as a potential therapeutic target for diverse diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Molecules and their functions in autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Autophagy and signaling: their role in cell survival and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Enhancement of myocardial regeneration through genetic engineering of cardiac progenitor cells expressing Pim-1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Pim2 complements Flt3 wild-type receptor in hematopoietic progenitor cell transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

TEL (ETV6)-AML1 (RUNX1) initiates self-renewing fetal pro-B cells in association with a transcriptional program shared with embryonic stem cells in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

How do stem cells find their way home?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

The oncogenic PIM kinase family regulates drug resistance through multiple mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Intermittent hypoxia is a key regulator of cancer cell and endothelial cell interplay in tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Targeting signal transduction in pancreatic cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

The essential role of PIM kinases in sarcoma growth and bone invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Targeting PIM kinase activity significantly augments the efficacy of cytarabine.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Pim kinase-dependent inhibition of c-Myc degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Pim-3 promotes the growth of human pancreatic cancer in the orthotopic nude mouse model through vascular endothelium growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

PIM Kinase Inhibitors Downregulate STAT3Tyr705 Phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Identification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

A Nucleolar Weapon in Our Fight for Regenerating Adult Hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FFON.13.229

21 January 2018

Identifiers

DOI

10.2217/FON.13.229

1 reference

31 August 2017

1 reference