(Q38406254)

2 September 2017

1 reference

PTEN: a yin-yang master regulator protein in health and disease (English)

1 reference

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase

2 September 2017

main subject

0 references

author

Rafael Pulido

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25843297%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Rafael Pulido

series ordinal

1

1 reference

2 September 2017

publication date

1 May 2015

1 reference

2 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25843297%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

77-78

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25843297%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

3-10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25843297%20AND%20SRC:MED&resulttype=core&format=json

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

8 June 2020

cites work

1 reference

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Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

7 January 2021

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Germline mutations in PTEN are present in Bannayan-Zonana syndrome

7 January 2021

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

7 January 2021

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Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast.

7 January 2021

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The multiple layers of non-genetic regulation of PTEN tumour suppressor activity

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PTEN function: the long and the short of it.

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Non-genomic loss of PTEN function in cancer: not in my genes.

7 January 2021

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The functions and regulation of the PTEN tumour suppressor

7 January 2021

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7 January 2021

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

7 January 2021

1 reference

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

7 January 2021

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PTEN increases autophagy and inhibits the ubiquitin-proteasome pathway in glioma cells independently of its lipid phosphatase activity

7 January 2021

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Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity

7 January 2021

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The significance of PTEN's protein phosphatase activity

7 January 2021

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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

7 January 2021

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The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models

7 January 2021

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Recent progress in mouse models for tumor suppressor genes and its implications in human cancer

7 January 2021

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The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey

7 January 2021

1 reference

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PTEN and myotubularin: novel phosphoinositide phosphatases

7 January 2021

1 reference

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PTEN is required for the normal progression of gastrulation by repressing cell proliferation after MBT in Xenopus embryos.

7 January 2021

1 reference

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Ptena and ptenb genes play distinct roles in zebrafish embryogenesis.

7 January 2021

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Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development.

7 January 2021

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Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways

7 January 2021

1 reference

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Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

7 January 2021

1 reference

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Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

7 January 2021

1 reference

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Intrinsic disorder in PTEN and its interactome confers structural plasticity and functional versatility

7 January 2021

1 reference

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Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis

7 January 2021

1 reference

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Nuclear PTEN: a tale of many tails

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

CREB is a novel nuclear target of PTEN phosphatase

7 January 2021

1 reference

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Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN

7 January 2021

1 reference

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A role for C. elegans Eph RTK signaling in PTEN regulation.

7 January 2021

1 reference

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN is a protein tyrosine phosphatase for IRS1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The p85beta regulatory subunit of PI3K serves as a substrate for PTEN protein phosphatase activity during insulin mediated signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

7 January 2021

1 reference

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Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Functional analysis of the protein phosphatase activity of PTEN

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

NHERFs, NEP, MAGUKs, and more: interactions that regulate PTEN.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN modulators: a patent review

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The protein-protein interaction-mediated inactivation of PTEN.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Reversible inactivation of the tumor suppressor PTEN by H2O2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Endogenous S-sulfhydration of PTEN helps protect against modification by nitric oxide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PCAF modulates PTEN activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN acetylation modulates its interaction with PDZ domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)

7 January 2021

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Redox regulation of PTEN by S-nitrosothiols

7 January 2021

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Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors.

7 January 2021

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SIPL1-facilitated PTEN ubiquitination contributes to its association with PTEN.

7 January 2021

1 reference

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RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

WWP2 is an E3 ubiquitin ligase for PTEN.

7 January 2021

1 reference

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Ubiquitination regulates PTEN nuclear import and tumor suppression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Regulation of the tumor suppressor PTEN by SUMO.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Nuclear trafficking of Pten after brain injury leads to neuron survival not death.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Germline disruption of Pten localization causes enhanced sex-dependent social motivation and increased glial production

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN in DNA damage repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The nuclear affairs of PTEN.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN: a new guardian of the genome.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Regulation of the tumor suppressor PTEN through exosomes: a diagnostic potential for prostate cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

A secreted PTEN phosphatase that enters cells to alter signaling and survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The PTEN Long N-tail is intrinsically disordered: increased viability for PTEN therapy

7 January 2021

1 reference

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A unified nomenclature and amino acid numbering for human PTEN.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTENα, a PTEN isoform translated through alternative initiation, regulates mitochondrial function and energy metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Catalysis by the tumor-suppressor enzymes PTEN and PTEN-L.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Molecular pathways: intercellular PTEN and the potential of PTEN restoration therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Cell biology. Where is PTEN?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Pills of PTEN? In and out for tumor suppression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

CSIG inhibits PTEN translation in replicative senescence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The Lilliputians and the Giant: An Emerging Oncogenic microRNA Network that Suppresses the PTEN Tumor Suppressor In Vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Subtle variations in Pten dose determine cancer susceptibility

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Reduction of Pten dose leads to neoplastic development in multiple organs of Pten (shRNA) mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Systemic elevation of PTEN induces a tumor-suppressive metabolic state

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Pten positively regulates brown adipose function, energy expenditure, and longevity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Therapeutic targeting of cancers with loss of PTEN function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The role of PTEN signaling perturbations in cancer and in targeted therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Tenets of PTEN tumor suppression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Inactivation of the PTEN gene protein product is associated with the invasiveness and metastasis, but not angiogenesis, of breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Reduced PTEN expression is associated with poor outcome and angiogenesis in invasive ductal carcinoma of the breast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Mutant PTEN in Cancer: Worse Than Nothing.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Molecular Characterization of the Dominant-Negative Role of Cancer-Associated PTEN: Sometimes, Null is Better

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

4-hydroxy estrogen induces DNA damage on codon 130/131 of PTEN in endometrial carcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN hamartoma tumor syndromes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN hamartomatous tumor syndromes (PHTS): rare syndromes with great relevance to common cancers and targeted drug development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN: A master regulator of neuronal structure, function, and plasticity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN signaling in autism spectrum disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

In vivo functional analysis of the counterbalance of hyperactive phosphatidylinositol 3-kinase p110 catalytic oncoproteins by the tumor suppressor PTEN.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN C-terminal deletion causes genomic instability and tumor development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Allele-specific tumor spectrum in pten knockin mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN mutations as a cause of constitutive insulin sensitivity and obesity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

A new pathway of glucocorticoid action for asthma treatment through the regulation of PTEN expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Activation of synovial fibroblasts in rheumatoid arthritis: lack of Expression of the tumour suppressor PTEN at sites of invasive growth and destruction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Amelioration of collagen-induced arthritis in rats by adenovirus-mediated PTEN gene transfer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Inhibition of mycobacterial infection by the tumor suppressor PTEN.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Transduction of PTEN proteins using the tat domain modulates TGF-β1-mediated signaling pathways and transdifferentiation in subconjunctival fibroblasts.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Impaired Fas response and autoimmunity in Pten+/- mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN plasticity: how the taming of a lethal gene can go too far

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Phosphatase PTEN in neuronal injury and brain disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase/Akt neuroprotective signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Peripheral axon regrowth: new molecular approaches

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN/mTOR and axon regeneration.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN inhibition enhances neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Selective deletion of PTEN in dopamine neurons leads to trophic effects and adaptation of striatal medium spiny projecting neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Effects of PTEN inhibition on regulation of tau phosphorylation in an okadaic acid-induced neurodegeneration model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN depletion decreases disease severity and modestly prolongs survival in a mouse model of spinal muscular atrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Regeneration of diabetic axons is enhanced by selective knockdown of the PTEN gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Inhibition of phosphatase and tensin homolog deleted on chromosome 10 decreases rat cortical neuron injury and blood-brain barrier permeability, and improves neurological functional recovery in traumatic brain injury model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Preservation of GABAA receptor function by PTEN inhibition protects against neuronal death in ischemic stroke

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN deletion prevents ischemic brain injury by activating the mTOR signaling pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Silencing the PTEN gene is protective against neuronal death induced by human immunodeficiency virus type 1 Tat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN gene silencing prevents HIV-1 gp120(IIIB)-induced degeneration of striatal neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Downregulation of PTEN at corneal wound sites accelerates wound healing through increased cell migration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Pharmacological inhibition of PTEN limits myocardial infarct size and improves left ventricular function postinfarction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The PTEN inhibitor bisperoxovanadium enhances myelination by amplifying IGF-1 signaling in rat and human oligodendrocyte progenitors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The safe use of a PTEN inhibitor for the activation of dormant mouse primordial follicles and generation of fertilizable eggs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Phosphatase and tensin homolog regulates the pluripotent state and lineage fate choice in human embryonic stem cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Bisperoxovanadium compounds are potent PTEN inhibitors.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

PTEN inhibitors: an evaluation of current compounds.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Interference with the PTEN-MAST2 interaction by a viral protein leads to cellular relocalization of PTEN.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

A selective irreversible inhibitor targeting a PDZ protein interaction domain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMETH.2015.02.009

10.1016/J.YMETH.2015.02.009

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25843297%20AND%20SRC:MED&resulttype=core&format=json

release_cthjdtni6zgz3mfv7ooty7jfii

8 June 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cthjdtni6zgz3mfv7ooty7jfii

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference