(Q38591386)

4 September 2017

title

Nonsense-mediated mRNA decay: an intricate machinery that shapes transcriptomes (English)

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4 September 2017

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1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26397022%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Torben Heick Jensen

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26397022%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

2

Torben Heick Jensen

1 reference

4 September 2017

Søren Lykke-Andersen

1

1 reference

4 September 2017

publication date

23 September 2015

1 reference

Nature Reviews Molecular Cell Biology

4 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26397022%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26397022%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26397022%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

665-677

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26397022%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrm4063

3 June 2020

exact match

0 references

cites work

Protecting the proteome: Eukaryotic cotranslational quality control pathways

1 reference

NMD: a multifaceted response to premature translational termination

21 January 2018

1 reference

Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells

21 January 2018

1 reference

Organizing principles of mammalian nonsense-mediated mRNA decay

21 January 2018

1 reference

Nonsense-mediated RNA decay--a switch and dial for regulating gene expression

21 January 2018

1 reference

Proteins involved in the degradation of cytoplasmic mRNA in the major eukaryotic model systems

21 January 2018

1 reference

Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein

21 January 2018

1 reference

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

21 January 2018

1 reference

Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay

21 January 2018

1 reference

A post-translational regulatory switch on UPF1 controls targeted mRNA degradation

21 January 2018

1 reference

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

21 January 2018

1 reference

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

21 January 2018

1 reference

Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon

21 January 2018

1 reference

Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)

21 January 2018

1 reference

The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.

21 January 2018

1 reference

Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements

21 January 2018

1 reference

An alternative branch of the nonsense-mediated decay pathway

21 January 2018

1 reference

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

21 January 2018

1 reference

RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD.

21 January 2018

1 reference

Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways

21 January 2018

1 reference

3' UTR length and messenger ribonucleoprotein composition determine endocleavage efficiencies at termination codons.

21 January 2018

1 reference

Upf1 senses 3'UTR length to potentiate mRNA decay

21 January 2018

1 reference

Rules that govern UPF1 binding to mRNA 3' UTRs

21 January 2018

1 reference

Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay

21 January 2018

1 reference

Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs

21 January 2018

1 reference

MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.

21 January 2018

1 reference

The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

21 January 2018

1 reference

The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts

21 January 2018

1 reference

A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay

21 January 2018

1 reference

The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex

21 January 2018

1 reference

The elongation, termination, and recycling phases of translation in eukaryotes

21 January 2018

1 reference

A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay

21 January 2018

1 reference

Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region

21 January 2018

1 reference

Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

21 January 2018

1 reference

A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay

21 January 2018

1 reference

The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein

21 January 2018

1 reference

Poly(A)-binding protein acts in translation termination via eukaryotic release factor 3 interaction and does not influence [PSI(+)] propagation

21 January 2018

1 reference

Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein

21 January 2018

1 reference

Eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay by two genetically separable mechanisms

21 January 2018

1 reference

The interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay

21 January 2018

1 reference

Circularization of mRNA by eukaryotic translation initiation factors

21 January 2018

1 reference

Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms

21 January 2018

1 reference

Translation factors promote the formation of two states of the closed-loop mRNP.

21 January 2018

1 reference

Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay.

21 January 2018

1 reference

Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon

21 January 2018

1 reference

Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations.

21 January 2018

1 reference

EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length.

21 January 2018

1 reference

Autoregulation of the nonsense-mediated mRNA decay pathway in human cells

21 January 2018

1 reference

Identification of elements in human long 3' UTRs that inhibit nonsense-mediated decay

21 January 2018

1 reference

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

21 January 2018

1 reference

The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus

21 January 2018

1 reference

The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

21 January 2018

1 reference

Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex

21 January 2018

1 reference

Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1

21 January 2018

1 reference

Y14 and hUpf3b form an NMD-activating complex

21 January 2018

1 reference

A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance

21 January 2018

1 reference

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

21 January 2018

1 reference

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.

21 January 2018

1 reference

Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD.

21 January 2018

1 reference

Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay

21 January 2018

1 reference

Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

21 January 2018

1 reference

Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex

21 January 2018

1 reference

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

21 January 2018

1 reference

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

21 January 2018

1 reference

Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells

21 January 2018

1 reference

Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes

21 January 2018

1 reference

SMG7 acts as a molecular link between mRNA surveillance and mRNA decay

21 January 2018

1 reference

Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover

21 January 2018

1 reference

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2.

21 January 2018

1 reference

Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex

21 January 2018

1 reference

Structural basis of the PNRC2-mediated link between mrna surveillance and decapping

21 January 2018

1 reference

SMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay

21 January 2018

1 reference

SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A.

21 January 2018

1 reference

Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies

21 January 2018

1 reference

Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

21 January 2018

1 reference

hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay

21 January 2018

1 reference

Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay

21 January 2018

1 reference

Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay

21 January 2018

1 reference

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

21 January 2018

1 reference

UPF2 is a critical regulator of liver development, function and regeneration

21 January 2018

1 reference

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay

21 January 2018

1 reference

Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis

21 January 2018

1 reference

Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns

21 January 2018

1 reference

Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability

21 January 2018

1 reference

Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability.

21 January 2018

1 reference

Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders

21 January 2018

1 reference

Orchestrated intron retention regulates normal granulocyte differentiation.

21 January 2018

1 reference

Hypoxic inhibition of nonsense-mediated RNA decay regulates gene expression and the integrated stress response

21 January 2018

1 reference

Stress-induced inhibition of nonsense-mediated RNA decay regulates intracellular cystine transport and intracellular glutathione through regulation of the cystine/glutamate exchanger SLC7A11.

21 January 2018

1 reference

The unfolded protein response is shaped by the NMD pathway

21 January 2018

1 reference

Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements

21 January 2018

1 reference

Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5.

21 January 2018

1 reference

The RNA degradation pathway regulates the function of GAS5 a non-coding RNA in mammalian cells

21 January 2018

1 reference

SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer

21 January 2018

1 reference

Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1.

21 January 2018

1 reference

Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast

21 January 2018

1 reference

Upf1 stimulates degradation of the product derived from aberrant messenger RNA containing a specific nonsense mutation by the proteasome

21 January 2018

1 reference

The Upf factor complex interacts with aberrant products derived from mRNAs containing a premature termination codon and facilitates their proteasomal degradation

21 January 2018

1 reference

CBP80-promoted mRNP rearrangements during the pioneer round of translation, nonsense-mediated mRNA decay, and thereafter

21 January 2018

1 reference

Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells.

21 January 2018

1 reference

eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells

21 January 2018

1 reference

Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm.

21 January 2018

1 reference

Nonsense-mediated decay in genetic disease: friend or foe?

21 January 2018

1 reference

Nonsense-mediated decay approaches the clinic

21 January 2018

1 reference

Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease

21 January 2018

1 reference

The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1

21 January 2018

1 reference

The functional consequences of intron retention: alternative splicing coupled to NMD as a regulator of gene expression

21 January 2018

1 reference

Quality control of transcription start site selection by nonsense-mediated-mRNA decay

21 January 2018

1 reference

Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay

21 January 2018

1 reference

SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs

21 January 2018

1 reference

Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay

21 January 2018

1 reference

Widespread intron retention in mammals functionally tunes transcriptomes

21 January 2018

1 reference

A perspective on mammalian upstream open reading frame function

21 January 2018

1 reference

High resolution transcriptome maps for wild-type and nonsense-mediated decay-defective Caenorhabditis elegans

21 January 2018

1 reference

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

21 January 2018

1 reference

Mechanisms and implications of programmed translational frameshifting

21 January 2018

1 reference

Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway

21 January 2018

1 reference

Selenocysteine incorporation: A trump card in the game of mRNA decay

21 January 2018

1 reference

Selenium regulation of the selenoprotein and nonselenoprotein transcriptomes in rodents

21 January 2018

1 reference

Nonsense-mediated decay factors are involved in the regulation of selenoprotein mRNA levels during selenium deficiency

21 January 2018

1 reference

Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure

21 January 2018

1 reference

Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability

21 January 2018

1 reference

Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay

21 January 2018

1 reference

UPF1 involvement in nuclear functions

21 January 2018

1 reference

Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1

21 January 2018

1 reference

SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs

21 January 2018

1 reference

The UPF3B gene, implicated in intellectual disability, autism, ADHD and childhood onset schizophrenia regulates neural progenitor cell behaviour and neuronal outgrowth

21 January 2018

1 reference

Posttranscriptional control of the stem cell and neurogenic programs by the nonsense-mediated RNA decay pathway

21 January 2018

1 reference

Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay

21 January 2018

1 reference

This message will self-destruct: NMD regulates axon guidance

21 January 2018

1 reference

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation

21 January 2018

1 reference

Reprogramming mRNA translation during stress

21 January 2018

1 reference

Intracellular calcium regulates nonsense-mediated mRNA decay

21 January 2018

1 reference

A novel role for hSMG-1 in stress granule formation

21 January 2018

1 reference

Staufen-mediated mRNA decay

21 January 2018

1 reference

Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2

21 January 2018

1 reference

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

21 January 2018

1 reference

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains

21 January 2018

1 reference

mRNP quality control goes regulatory

21 January 2018

1 reference

CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex

21 January 2018

1 reference

The unfolded protein response affects readthrough of premature termination codons

31 March 2020

1 reference

Nonsense surveillance in lymphocytes?

31 March 2020

1 reference

The coupling of alternative splicing and nonsense-mediated mRNA decay.

31 March 2020

1 reference

Up-frameshift protein 1 (UPF1): multitalented entertainer in RNA decay

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26397022