(Q38691377)

5 September 2017

title

Progress in the Development of non-BET Bromodomain Chemical Probes (English)

1 reference

5 September 2017

author

Nicholas C.O. Tomkinson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749027%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Philip G Humphreys

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749027%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Natalie H Theodoulou

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749027%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Rab K Prinjha

3

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10 June 2020

language of work or name

1 reference

8 January 2016

1 reference

5 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749027%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

11

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10 June 2020

issue

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749027%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

477-487

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749027%20AND%20SRC:MED&resulttype=core&format=json

Epigenetic protein families: a new frontier for drug discovery

10 June 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Small molecule bromodomain inhibitors: extending the druggable genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Structure and acetyl-lysine recognition of the bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

A rationale to target the SWI/SNF complex for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Target validation using chemical probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Epigenetic chemical probes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

The bromodomain interaction module

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Histone recognition and large-scale structural analysis of the human bromodomain family

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Suppression of inflammation by a synthetic histone mimic

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Discovery and characterization of small molecule inhibitors of the BET family bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Selective inhibition of BET bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Place your BETs: the therapeutic potential of bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Small-molecule modulators for epigenetics targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

BET bromodomain inhibitors: a patent review

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Small molecule inhibitors of bromodomain-acetyl-lysine interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Bromodomains and their pharmacological inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Fragment-based screening of the bromodomain of ATAD2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

NanoBRET--A Novel BRET Platform for the Analysis of Protein-Protein Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

High-resolution enabled TMT 8-plexing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Target structure-based discovery of small molecules that block human p53 and CREB binding protein association

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Rational design of cyclic peptide modulators of the transcriptional coactivator CBP: a new class of p53 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Fragment-Based Design of Selective Nanomolar Ligands of the CREBBP Bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Selective small molecules blocking HIV-1 Tat and coactivator PCAF association

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Genetic and epigenetic screening for gene alterations of the chromatin-remodeling factor, SMARCA4/BRG1, in lung tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Biased multicomponent reactions to develop novel bromodomain inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Target (In)Validation: A Critical, Sometimes Unheralded, Role of Modern Medicinal Chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

Inhibition of bromodomain-mediated protein–protein interactions as a novel therapeutic strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.201500540

21 January 2018

Identifiers

DOI

10.1002/CMDC.201500540

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26749027%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference