(Q38882537)

7 September 2017

1 reference

title

A fate worse than death: apoptosis as an oncogenic process (English)

1 reference

7 September 2017

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27364482%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Stephen Tait

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27364482%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Gabriel Ichim

series ordinal

1

1 reference

7 September 2017

Stephen W G Tait

series ordinal

2

1 reference

7 September 2017

language of work or name

English

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publication date

1 July 2016

1 reference

7 September 2017

Nature Reviews Cancer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27364482%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27364482%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27364482%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

539-548

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27364482%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrc.2016.58

9 June 2020

exact match

0 references

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Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

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Apoptosis: controlled demolition at the cellular level

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Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

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Mitochondria and cell death: outer membrane permeabilization and beyond

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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Die another way--non-apoptotic mechanisms of cell death

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The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells

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Decreased apoptosome activity with neuronal differentiation sets the threshold for strict IAP regulation of apoptosis

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GAPDH and autophagy preserve survival after apoptotic cytochrome c release in the absence of caspase activation.

31 March 2020

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A unified model of mammalian BCL-2 protein family interactions at the mitochondria.

31 March 2020

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

31 March 2020

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Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

31 March 2020

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

31 March 2020

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Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms

31 March 2020

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

31 March 2020

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Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy

31 March 2020

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Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

31 March 2020

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The Bcl-2 apoptotic switch in cancer development and therapy

31 March 2020

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

31 March 2020

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Mitochondrial apoptosis: killing cancer using the enemy within.

31 March 2020

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Apoptosis index is a predictor of metastatic phenotype in patients with early stage squamous carcinoma of the tongue: a hypothesis to support this paradoxical association

31 March 2020

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Extent, relationship and prognostic significance of apoptosis and cell proliferation in synovial sarcoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.58

The role and prognostic value of apoptosis in colorectal carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.58

Number of apoptotic cells as a prognostic marker in invasive breast cancer

31 March 2020

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BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received

31 March 2020

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High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology

31 March 2020

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BCL-2 expression is prognostic for improved survival in non-small cell lung cancer

31 March 2020

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Enhanced levels of the apoptotic BAX/BCL-2 ratio in children with acute lymphoblastic leukemia and high-risk features

31 March 2020

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

31 March 2020

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Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways.

31 March 2020

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Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role

31 March 2020

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Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila.

31 March 2020

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Fas-induced arachidonic acid release is mediated by Ca2+-independent phospholipase A2 but not cytosolic phospholipase A2, which undergoes proteolytic inactivation

31 March 2020

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Genetic Studies of the Relationship of Tumour–Host Cells: Effect of Tumour Cells killed by X-rays upon the Growth of Admixed Viable Cells

31 March 2020

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UVB-irradiated apoptotic cells induce accelerated growth of co-implanted viable tumor cells in immune competent mice.

31 March 2020

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Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy

31 March 2020

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Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance

31 March 2020

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Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity.

31 March 2020

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p53 in survival, death and metabolic health: a lifeguard with a licence to kill

31 March 2020

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p53-mediated hematopoietic stem and progenitor cell competition.

31 March 2020

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Irradiation selects for p53-deficient hematopoietic progenitors.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.58

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.58

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.58

Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis

31 March 2020

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Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

31 March 2020

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Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death.

31 March 2020

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Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation

31 March 2020

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PUMA-mediated apoptosis drives chemical hepatocarcinogenesis in mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Bcl-2 expression inhibits liver carcinogenesis and delays the development of proliferating foci

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

The BH3-only protein BID impairs the p38-mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Deletion of Bid impedes cell proliferation and hepatic carcinogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Recent developments in myelodysplastic syndromes.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Epidemiology of myelodysplastic syndromes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Therapy-related myeloid leukemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

PUMA promotes apoptosis of hematopoietic progenitors driving leukemic progression in a mouse model of myelodysplasia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Phagocytosis of apoptotic cells in homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Upregulation of fractalkine contributes to the proliferative response of prostate cancer cells to hypoxia via promoting the G1/S phase transition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

CX3CL1 at the crossroad of EGF signals: Relevance for the progression of ERBB2(+) breast carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Tumor-promoting functions of adenosine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Tumor-associated macrophages: from mechanisms to therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Efferocytosis produces a prometastatic landscape during postpartum mammary gland involution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Postpartum diagnosis demonstrates a high risk for metastasis and merits an expanded definition of pregnancy-associated breast cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

The complexity of the relationships between age at first birth and breast cancer incidence curves implicate pregnancy in cancer initiation as well as promotion of existing lesions. Preface.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

TRAIL treatment provokes mutations in surviving cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Caspase-3 promotes genetic instability and carcinogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Real-time single cell analysis of Smac/DIABLO release during apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Quantitative analysis of pathways controlling extrinsic apoptosis in single cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Mitochondria as therapeutic targets for cancer chemotherapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Resistance to caspase-independent cell death requires persistence of intact mitochondria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Cellular responses to a prolonged delay in mitosis are determined by a DNA damage response controlled by Bcl-2 family proteins.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Lymphoma development in Bax transgenic mice is inhibited by Bcl-2 and associated with chromosomal instability.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Hijacked in cancer: the KMT2 (MLL) family of methyltransferases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL)-multiple rather than a single mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Role of apoptotic nuclease caspase-activated DNase in etoposide-induced treatment-related acute myelogenous leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Cancer and inflammation: an old intuition with rapidly evolving new concepts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

The BH3 mimetic ABT-737 induces cancer cell senescence.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Programmed cell death in animal development and disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Multiple functions of BCL-2 family proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Central roles of apoptotic proteins in mitochondrial function.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Non-apoptotic roles of Bcl-2 family: the calcium connection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Bcl-xL promotes metastasis independent of its anti-apoptotic activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

TRAIL promotes membrane blebbing, detachment and migration of cells displaying a dysfunctional intrinsic pathway of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Mutant PIK3CA licenses TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

The role of CD95 and CD95 ligand in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

CD95 promotes tumour growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Death induced by CD95 or CD95 ligand elimination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

CD95 and CD95L promote and protect cancer stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Genetic analysis of chemoresistance in primary murine lymphomas.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Antiapoptotic BCL-2 is required for maintenance of a model leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Getting around lethality with inducible Cre-mediated excision

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Mito-priming as a method to engineer Bcl-2 addiction.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Visualization of caspase-3-like activity in cells using a genetically encoded fluorescent biosensor activated by protein cleavage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

In vivo imaging of drug-induced mitochondrial outer membrane permeabilization at single-cell resolution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Imaging hallmarks of cancer in living mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Intravital FRET imaging of tumor cell viability and mitosis during chemotherapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

M867, a novel selective inhibitor of caspase-3 enhances cell death and extends tumor growth delay in irradiated lung cancer models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Modulation of radiochemoimmunotherapy-induced B16 melanoma cell death by the pan-caspase inhibitor zVAD-fmk induces anti-tumor immunity in a HMGB1-, nucleotide- and T-cell-dependent manner

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Inflammation-driven carcinogenesis is mediated through STING

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Diverse roles of STING-dependent signaling on the development of cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Immune surveillance of tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Targeting IAP proteins for therapeutic intervention in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Mitochondrial regulation of cell death.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Real time analysis of tumor necrosis factor-related apoptosis-inducing ligand/cycloheximide-induced caspase activities during apoptosis initiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Small-molecule activators of a proenzyme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Inflammation and necrosis promote tumour growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Immunity, Inflammation, and Cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Prognostic value of Bcl-2 in breast cancer patients treated with neoadjuvant anthracycline based chemotherapy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Bcl-2 expression correlates with lymphovascular invasion and long-term prognosis in breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Evidence that the p53 negative / Bcl-2 positive phenotype is an independent indicator of good prognosis in colorectal cancer: a tissue microarray study of 460 patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Prognostic significance of bcl-2 expression in resected pN2 non-small cell lung cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

High Bad and Bax mRNA expression correlate with negative outcome in acute myeloid leukemia (AML).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.58

Increased BAX expression is associated with an increased risk of relapse in childhood acute lymphocytic leukemia.

31 March 2020

1 reference

12 December 2020

Bcl-2 is a useful prognostic marker in Dukes' B colon cancer.

1 reference

12 December 2020

bcl-2 and apoptosis in lymph node positive breast carcinoma.

1 reference

12 December 2020

Correlation between Apoptosis and Histological Grade of Transitional Cell Carcinoma of Urinary Bladder.

1 reference

12 December 2020

Apoptotic stimuli initiate MLL-AF9 translocations that are transcribed in cells capable of division.

1 reference

12 December 2020

Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration

1 reference

12 December 2020

Does the expression of BCL2 have prognostic significance in malignant peritoneal mesothelioma?

1 reference

12 December 2020

The biology of cell death in tumours

1 reference

12 December 2020

Bcl-2, Bcl-X, Bax, and Bak expression in short- and long-lived patients with diffuse large B-cell lymphomas

1 reference

12 December 2020