(Q39027265)

8 September 2017

M(o)TOR of pseudo-hypoxic state in aging: rapamycin to the rescue (English)

1 reference

8 September 2017

0 references

1 reference

2

Mikhail V Blagosklonny

1 reference

8 September 2017

Olga V Leontieva

1

1 reference

8 September 2017

23 January 2014

1 reference

8 September 2017

7

1 reference

based on heuristic

inferred from page(s)

published in

Cell Cycle

1 reference

8 September 2017

13

1 reference

8 September 2017

4

1 reference

8 September 2017

509-515

1 reference

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

8 September 2017

1 reference

Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong?

21 January 2018

1 reference

Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster

21 January 2018

1 reference

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

21 January 2018

1 reference

When a theory of aging ages badly.

21 January 2018

1 reference

Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage

21 January 2018

1 reference

The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan.

21 January 2018

1 reference

Extending life span by increasing oxidative stress

21 January 2018

1 reference

Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species.

21 January 2018

1 reference

21 January 2018

1 reference

Hormesis does not make sense except in the light of TOR-driven aging

21 January 2018

1 reference

Answering the ultimate question "what is the proximal cause of aging?"

21 January 2018

1 reference

Genetics of longevity in model organisms: debates and paradigm shifts

21 January 2018

1 reference

Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?

21 January 2018

1 reference

Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition

21 January 2018

1 reference

Growth and aging: a common molecular mechanism

21 January 2018

1 reference

M(o)TOR of aging: MTOR as a universal molecular hypothalamus

21 January 2018

1 reference

Validation of anti-aging drugs by treating age-related diseases

21 January 2018

1 reference

TOR-driven aging: speeding car without brakes

21 January 2018

1 reference

Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans).

21 January 2018

1 reference

Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives

21 January 2018

1 reference

Prospective treatment of age-related diseases by slowing down aging

21 January 2018

1 reference

Rapamycin extends life- and health span because it slows aging

21 January 2018

1 reference

TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists

21 January 2018

1 reference

21 January 2018

1 reference

mTOR is a key modulator of ageing and age-related disease

21 January 2018

1 reference

The TOR pathway comes of age

21 January 2018

1 reference

Ruminations on dietary restriction and aging.

21 January 2018

1 reference

With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging

21 January 2018

1 reference

Role of TOR signaling in aging and related biological processes in Drosophila melanogaster

21 January 2018

1 reference

A double whammy for aging? Rapamycin extends lifespan and inhibits cancer in inbred female mice.

21 January 2018

1 reference

mTOR in aging, metabolism, and cancer

21 January 2018

1 reference

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

1 reference

Intermittent supplementation with rapamycin as a dietary restriction mimetic.

21 January 2018

1 reference

Extending healthy life span--from yeast to humans

21 January 2018

1 reference

Of mice and men: the benefits of caloric restriction, exercise, and mimetics.

21 January 2018

1 reference

Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network

21 January 2018

1 reference

mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

21 January 2018

1 reference

Rapamycin extends maximal lifespan in cancer-prone mice

21 January 2018

1 reference

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice.

21 January 2018

1 reference

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

21 January 2018

1 reference

Rapamycin slows aging in mice

21 January 2018

1 reference

Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

21 January 2018

1 reference

New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis

21 January 2018

1 reference

Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

21 January 2018

1 reference

Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors

21 January 2018

1 reference

Rapamycin extends life and health in C57BL/6 mice

21 January 2018

1 reference

Rapamycin extends murine lifespan but has limited effects on aging

21 January 2018

1 reference

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome

21 January 2018

1 reference

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

21 January 2018

1 reference

Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

21 January 2018

1 reference

Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome

21 January 2018

1 reference

eRapa restores a normal life span in a FAP mouse model.

21 January 2018

1 reference

Prolonged rapamycin treatment led to beneficial metabolic switch

21 January 2018

1 reference

Rapamycin prolongs female reproductive lifespan

21 January 2018

1 reference

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

21 January 2018

1 reference

Tumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?

21 January 2018

1 reference

Growth stimulation leads to cellular senescence when the cell cycle is blocked

21 January 2018

1 reference

Paradoxical suppression of cellular senescence by p53

21 January 2018

1 reference

Hypoxia suppresses conversion from proliferative arrest to cellular senescence

21 January 2018

1 reference

DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence

21 January 2018

1 reference

MEK drives cyclin D1 hyperelevation during geroconversion

21 January 2018

1 reference

Rapamycin decelerates cellular senescence

21 January 2018

1 reference

Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential

21 January 2018

1 reference

Pseudo-DNA damage response in senescent cells

21 January 2018

1 reference

p21(Waf1) is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate

21 January 2018

1 reference

Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.

21 January 2018

1 reference

Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescence

21 January 2018

1 reference

Rapamycin enhances long-term hematopoietic reconstitution of ex vivo expanded mouse hematopoietic stem cells by inhibiting senescence

21 January 2018

1 reference

Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling

21 January 2018

1 reference

mTOR-regulated senescence and autophagy during reprogramming of somatic cells to pluripotency: a roadmap from energy metabolism to stem cell renewal and aging

21 January 2018

1 reference

Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug

21 January 2018

1 reference

Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence

21 January 2018

1 reference

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

21 January 2018

1 reference

Exploiting the mTOR paradox for disease prevention

21 January 2018

1 reference

Aging, stem cells, and mammalian target of rapamycin: a prospect of pharmacologic rejuvenation of aging stem cells

21 January 2018

1 reference

Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress

21 January 2018

1 reference

mTORC1 signaling governs hematopoietic stem cell quiescence

21 January 2018

1 reference

Metabolic control by target of rapamycin and autophagy during ageing - a mini-review

21 January 2018

1 reference

Immunostimulatory activity of lifespan-extending agents.

21 January 2018

1 reference

mTOR's role in ageing: protein synthesis or autophagy?

21 January 2018

1 reference

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

21 January 2018

1 reference

Cell senescence and hypermitogenic arrest

21 January 2018

1 reference

Cell cycle arrest is not senescence

21 January 2018

1 reference

Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells

21 January 2018

1 reference

HIF-1: upstream and downstream of cancer metabolism

21 January 2018

1 reference

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

21 January 2018

1 reference

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

21 January 2018

1 reference

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

21 January 2018

1 reference

Regulation of hypoxia-inducible factor (HIF)-1 activity and expression of HIF hydroxylases in response to insulin-like growth factor I.

21 January 2018

1 reference

The purpose of the HIF-1/PHD feedback loop: to limit mTOR-induced HIF-1α.

21 January 2018

1 reference

Weak p53 permits senescence during cell cycle arrest

21 January 2018

1 reference

Conserved role of medium acidification in chronological senescence of yeast and mammalian cells

21 January 2018

1 reference

A new chronological survival assay in mammalian cell culture

21 January 2018

1 reference

A molecular mechanism of chronological aging in yeast.

21 January 2018

1 reference

Replicative and chronological aging in Saccharomyces cerevisiae.

21 January 2018

1 reference

Extension of chronological life span in yeast by decreased TOR pathway signaling

21 January 2018

1 reference

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

Molecular damage in cancer: an argument for mTOR-driven aging

21 January 2018

1 reference

Prevention of cancer by inhibiting aging

21 January 2018

1 reference

An anti-aging drug today: from senescence-promoting genes to anti-aging pill

21 January 2018

1 reference

Rapamycin and quasi-programmed aging: four years later

21 January 2018

1 reference

Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal

21 January 2018

1 reference

How to save Medicare: the anti-aging remedy

21 January 2018

1 reference

Rapamycin: killing two birds with one stone

21 January 2018

1 reference

The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway

21 January 2018

1 reference

Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4161/CC.27973

1 reference

8 September 2017

1 reference

PubMed ID

24496328