(Q39695174)

English

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis

scientific article published on June 2010

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scholarly article

1 reference

Europe PubMed Central

14 September 2017

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis (English)

1 reference

Europe PubMed Central

14 September 2017

1 reference

based on heuristic

inferred from title

Christian Haass

4

object named as

Christian Haass

0 references

2

object named as

Regina Fluhrer

1 reference

Europe PubMed Central

14 September 2017

author name string

Akio Fukumori

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632680&resulttype=core&format=json

15 May 2020

Harald Steiner

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632680&resulttype=core&format=json

15 May 2020

Regina Fluhrer

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632680&resulttype=core&format=json

15 May 2020

Christian Haass

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632680&resulttype=core&format=json

15 May 2020

language of work or name

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publication date

1 June 2010

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Europe PubMed Central

14 September 2017

Journal of Neuroscience

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Europe PubMed Central

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15 May 2020

30

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632680&resulttype=core&format=json

15 May 2020

23

1 reference

Europe PubMed Central

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15 May 2020

7853-7862

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632680&resulttype=core&format=json

15 May 2020

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolysis of presenilin in vitro: inhibition by gamma-secretase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reconstitution of gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between presenilinase and gamma-secretase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of gamma-secretase inhibitor potency determinants on presenilin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

From presenilinase to gamma-secretase, cleave to capacitate

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intramembrane proteolysis by gamma-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intramembrane-cleaving proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toward structural elucidation of the gamma-secretase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20534834

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1443-10.2010

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632680&resulttype=core&format=json

15 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632680&resulttype=core&format=json

15 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6632680&resulttype=core&format=json

15 May 2020

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