(Q40650184)

English

Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway

scientific article published on May 2003

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scholarly article

1 reference

Europe PubMed Central

22 September 2017

Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway (English)

1 reference

Europe PubMed Central

22 September 2017

Alzheimer's disease

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1 reference

based on heuristic

inferred from title

7

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Christian Haass

5

object named as

Christian Haass

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author name string

Celio A Marques

1

1 reference

Europe PubMed Central

22 September 2017

Uta Keil

2

1 reference

Europe PubMed Central

22 September 2017

Astrid Bonert

3

1 reference

Europe PubMed Central

22 September 2017

Barbara Steiner

4

1 reference

Europe PubMed Central

22 September 2017

Walter E Muller

6

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Europe PubMed Central

22 September 2017

language of work or name

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publication date

1 May 2003

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Europe PubMed Central

22 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

22 September 2017

278

1 reference

Europe PubMed Central

22 September 2017

28294-28302

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Europe PubMed Central

22 September 2017

30

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Europe PubMed Central

22 September 2017

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

The gene defects responsible for familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Amyloid beta-protein and the genetics of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Stable beta-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Receptor for advanced glycation end products plays a more important role in cellular survival than in neurite outgrowth during retinoic acid-induced differentiation of neuroblastoma cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Oxidative stress increases expression and activity of BACE in NT2 neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

The Swedish APP670/671 Alzheimer's disease mutation: the first evidence for strikingly increased oxidative injury in the temporal inferior cortex.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Interactions of oxidative stress with cellular calcium dynamics and glucose metabolism in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Apoptosis in the nervous system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Redox-active iron mediates amyloid-beta toxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Alzheimer's disease is a synaptic failure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Intracellular biology of Alzheimer's disease amyloid beta peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Caspase-2 can trigger cytochrome C release and apoptosis from the nucleus.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Caspases: their intracellular localization and translocation during apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Analyzing mitochondrial changes during apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M212265200

21 January 2018

Identifiers

10.1074/JBC.M212265200

1 reference

Europe PubMed Central

22 September 2017

1 reference

Europe PubMed Central

22 September 2017

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