(Q44945718)

7 December 2017

Bcl-2 phosphorylation and apoptosis activated by damaged microtubules require mTOR and are regulated by Akt. (English)

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7 December 2017

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4

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7 December 2017

Annamaria Bevilacqua

3

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Giuliana Gatti

5

object named as

Giuliana Gatti

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7 December 2017

Laura Asnaghi

1

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7 December 2017

Angela Calastretti

2

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7 December 2017

Gianfranco Canti

6

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7 December 2017

Domenico Delia

7

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7 December 2017

Sergio Capaccioli

8

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7 December 2017

Angelo Nicolin

9

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7 December 2017

language of work or name

English

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publication date

1 July 2004

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7 December 2017

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7 December 2017

23

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7 December 2017

34

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7 December 2017

5781-5791

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1207698

7 December 2017

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cites work

Insulin signal transduction through protein kinase cascades.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

Coordinated regulation of life and death by RB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

The Bcl2 family: regulators of the cellular life-or-death switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

Modelling the molecular circuitry of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

Tor signalling in bugs, brain and brawn

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

Histone-deacetylase inhibitors: novel drugs for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

Microtubules and actin filaments: dynamic targets for cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

Phosphorylation of Bcl-2 is a marker of M phase events and not a determinant of apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

c-MYC: more than just a matter of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Convergence of mitogenic and DNA damage signaling in the G1 phase of the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Bcl-2 protein is required for the adenine/uridine-rich element (ARE)-dependent degradation of its own messenger.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Post-transcriptional regulation of gene expression by degradation of messenger RNAs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Molecular effects of paclitaxel: myths and reality (a critical review).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

PKB binding proteins. Getting in on the Akt.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Control of p70 s6 kinase by kinase activity of FRAP in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Damaged microtubules can inactivate BCL-2 by means of the mTOR kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Rapamycin increases the cellular concentration of the BCL-2 protein and exerts an anti-apoptotic effect

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

A novel pathway regulating the mammalian target of rapamycin (mTOR) signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Clinical advances in therapies targeting the interleukin-2 receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

The retinoblastoma protein binds the promoter of the survival gene bcl-2 and regulates its transcription in epithelial cells through transcription factor AP-2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

VEGF and the quest for tumour angiogenesis factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

The p53 tumor suppressor: critical regulator of life & death in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

A matter of life and death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Inhibition of protein kinase B/Akt. implications for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

The role of PI3K in immune cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Philadelphia chromosome-positive leukemias: from basic mechanisms to molecular therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Chemical genetics: tailoring tools for cell biology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Taxol-induced apoptosis in human SKOV3 ovarian and MCF7 breast carcinoma cells is caspase-3 and caspase-9 independent

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

The modular phosphorylation and activation of p70s6k.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Regulation of the G2/M transition by p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Control of cell survival by IGF signaling pathways.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Signaling life and death in the thymus: timing is everything

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207698

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207698

1 reference

7 December 2017

1 reference