(Q46453776)

22 December 2017

review article

1 reference

title

The emerging role of systems biology for engineering protein production in CHO cells (English)

1 reference

22 December 2017

6

Nathan E Lewis

1 reference

22 December 2017

Austin W T Chiang

1 reference

ORCID Public Data File 2021

author name string

Chih-Chung Kuo

1

1 reference

22 December 2017

Austin Wt Chiang

2

1 reference

22 December 2017

Isaac Shamie

3

1 reference

22 December 2017

Mojtaba Samoudi

4

1 reference

22 December 2017

Jahir M Gutierrez

5

1 reference

22 December 2017

publication date

6 December 2017

1 reference

22 December 2017

Current Opinion in Biotechnology

published in

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22 December 2017

volume

51

1 reference

22 December 2017

page(s)

64-69

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22 December 2017

Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome

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Mammalian Systems Biotechnology Reveals Global Cellular Adaptations in a Recombinant CHO Cell Line.

29 September 2018

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Polysome profiling of mAb producing CHO cell lines links translational control of cell proliferation and recombinant mRNA loading onto ribosomes with global and recombinant protein synthesis.

29 September 2018

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Glycoengineering of CHO Cells to Improve Product Quality

29 September 2018

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Model-based analysis of N-glycosylation in Chinese hamster ovary cells

29 September 2018

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Identification and control of novel growth inhibitors in fed-batch cultures of Chinese hamster ovary cells

29 September 2018

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Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.

29 September 2018

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Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data

29 September 2018

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What can mathematical modelling say about CHO metabolism and protein glycosylation?

29 September 2018

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A Systematic Evaluation of Methods for Tailoring Genome-Scale Metabolic Models

29 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Automated microfluidic sorting of mammalian cells labeled with magnetic microparticles for those that efficiently express and secrete a protein of interest.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

29 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions.

29 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Predictive glycoengineering of biosimilars using a Markov chain glycosylation model.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Modulating carbohydrate-protein interactions through glycoengineering of monoclonal antibodies to impact cancer physiology

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

High-throughput screening and selection of mammalian cells for enhanced protein production

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Comparison of Cas9 activators in multiple species

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Quantitative feature extraction from the Chinese hamster ovary bioprocess bibliome using a novel meta-analysis workflow

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

The use of lectin microarray for assessing glycosylation of therapeutic proteins

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Dynamics of immature mAb glycoform secretion during CHO cell culture: An integrated modelling framework.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

A Markov chain model for N-linked protein glycosylation--towards a low-parameter tool for model-driven glycoengineering

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

The art of CHO cell engineering: A comprehensive retrospect and future perspectives

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Systems strategies for developing industrial microbial strains

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Engineered CHO cells for production of diverse, homogeneous glycoproteins.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

The use of 'Omics technology to rationally improve industrial mammalian cell line performance

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

CRISPR/Cas9-mediated genome engineering of CHO cell factories: Application and perspectives

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Using Genome-scale Models to Predict Biological Capabilities

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

CHOgenome.org 2.0: Genome resources and website updates.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Benchmarking of commercially available CHO cell culture media for antibody production.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

High-antibody-producing Chinese hamster ovary cells up-regulate intracellular protein transport and glutathione synthesis

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Global insights into the Chinese hamster and CHO cell transcriptomes.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Systems glycobiology for glycoengineering

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Kinetic models in industrial biotechnology - Improving cell factory performance

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

A guide to genome engineering with programmable nucleases

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Proteins improving recombinant antibody production in mammalian cells

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Predicting the expression of recombinant monoclonal antibodies in Chinese hamster ovary cells based on sequence features of the CDR3 domain.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

The emerging CHO systems biology era: harnessing the 'omics revolution for biotechnology

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

CHO cell engineering to prevent polypeptide aggregation and improve therapeutic protein secretion

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Metabolomics profiling of extracellular metabolites in CHO-K1 cells cultured in different types of growth media

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Optimized signal peptides for the development of high expressing CHO cell lines

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Multivariate analysis of cell culture bioprocess data--lactate consumption as process indicator

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Systems biotechnology of animal cells: the road to prediction

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Metabolite profiling of CHO cells with different growth characteristics.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Engineering the chaperone network of CHO cells for optimal recombinant protein production and authenticity.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Predicting cell-specific productivity from CHO gene expression.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Strategies for selecting recombinant CHO cell lines for cGMP manufacturing: realizing the potential in bioreactors

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Guidelines to cell engineering for monoclonal antibody production.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Transcriptome and proteome analysis of Chinese hamster ovary cells under low temperature and butyrate treatment

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

25 years of recombinant proteins from reactor-grown cells - where do we go from here?

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

A comparative study of different vector designs for the mammalian expression of recombinant IgG antibodies

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Engineering cells for cell culture bioprocessing--physiological fundamentals.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Engineering mammalian cell factories for improved recombinant monoclonal antibody production: lessons from nature?

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Production of recombinant protein therapeutics in cultivated mammalian cells

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5988649

Improvements in protein production in mammalian cells from targeted metabolic engineering

29 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29223005

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.COPBIO.2017.11.015

1 reference

22 December 2017

PMC publication ID

5988649

0 references

1 reference

22 December 2017