(Q47692117)

4 February 2018

title

SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology (English)

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4 February 2018

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Hitoshi Shimano

1

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4 February 2018

Ryuichiro Sato

series ordinal

2

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4 February 2018

publication date

29 August 2017

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4 February 2018

Nature Reviews Endocrinology

published in

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4 February 2018

volume

13

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4 February 2018

issue

12

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4 February 2018

page(s)

710-730

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4 February 2018

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

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A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans

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SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast

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Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a.

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Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

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Selective coactivator interactions in gene activation by SREBP-1a and -1c.

21 January 2018

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Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

21 January 2018

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SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein

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An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

21 January 2018

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Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition.

21 January 2018

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Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

21 January 2018

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Heat Shock Protein 90 Modulates Lipid Homeostasis by Regulating the Stability and Function of Sterol Regulatory Element-binding Protein (SREBP) and SREBP Cleavage-activating Protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Direct Demonstration That Loop1 of Scap Binds to Loop7: A CRUCIAL EVENT IN CHOLESTEROL HOMEOSTASIS.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

A novel processing system of sterol regulatory element-binding protein-1c regulated by polyunsaturated fatty acid

21 January 2018

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COPI-mediated retrieval of SCAP is crucial for regulating lipogenesis under basal and sterol-deficient conditions

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The immediate-early growth response in regenerating liver and insulin-stimulated H-35 cells: comparison with serum-stimulated 3T3 cells and identification of 41 novel immediate-early genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Unsaturated fatty acids down-regulate srebp isoforms 1a and 1c by two mechanisms in HEK-293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

TAK1 regulates hepatic lipid homeostasis through SREBP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

A potential mechanism underlying atypical antipsychotics-induced lipid disturbances

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Interferon-inducible cholesterol-25-hydroxylase inhibits hepatitis C virus replication via distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Inhibition of pathogenic non-enveloped viruses by 25-hydroxycholesterol and 27-hydroxycholesterol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

25-Hydroxycholesterols in innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The STING in the tail for cytosolic DNA-dependent activation of IRF3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Cholesterol 25-hydroxylation activity of CYP3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Knockout of mouse Cyp3a gene enhances synthesis of cholesterol and bile acid in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Transcription-dependent degradation controls the stability of the SREBP family of transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Glycogen synthase kinase-3-mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Multiple DNA elements for sterol regulatory element-binding protein and NF-Y are responsible for sterol-regulated transcription of the genes for human 3-hydroxy-3-methylglutaryl coenzyme A synthase and squalene synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Interaction between sterol regulatory element-binding proteins and liver receptor homolog-1 reciprocally suppresses their transcriptional activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

ATF6 modulates SREBP2-mediated lipogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Role of LXRs in control of lipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Hepatic TRAP80 selectively regulates lipogenic activity of liver X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The brown fat-enriched secreted factor Nrg4 preserves metabolic homeostasis through attenuation of hepatic lipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Transcriptional regulation of hepatic lipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The Akt-SREBP nexus: cell signaling meets lipid metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

A growing role for mTOR in promoting anabolic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Selective versus total insulin resistance: a pathogenic paradox

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Akt2 is required for hepatic lipid accumulation in models of insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Livers with constitutive mTORC1 activity resist steatosis independent of feedback suppression of Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Fatty acid-regulated transcription factors in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Elovl5 regulates the mTORC2-Akt-FOXO1 pathway by controlling hepatic cis-vaccenic acid synthesis in diet-induced obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

SREBPs suppress IRS-2-mediated insulin signalling in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFkappaB in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

TSC2 mediates cellular energy response to control cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Phosphorylation of sterol regulatory element binding protein-1a by protein kinase A (PKA) regulates transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Sirtuin 1 regulates SREBP-1c expression in a LXR-dependent manner in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Dietary polyunsaturated fatty acids and regulation of gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Identification of Rbd2 as a candidate protease for sterol regulatory element binding protein (SREBP) cleavage in fission yeast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Amino acid homeostasis and signalling in mammalian cells and organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The crosstalk between gut inflammation and gastrointestinal disorders during acute pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Regulation of the PTEN promoter by statins and SREBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Glutamine stimulates the gene expression and processing of sterol regulatory element binding proteins, thereby increasing the expression of their target genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Neuregulin-activated ERBB4 induces the SREBP-2 cholesterol biosynthetic pathway and increases low-density lipoprotein uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Positive feedback loop between PI3K-Akt-mTORC1 signaling and the lipogenic pathway boosts Akt signaling: induction of the lipogenic pathway by a melanoma antigen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Mevalonate Pathway and Human Cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

On the Origin of Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Sterol Regulatory Element Binding Protein Regulates the Expression and Metabolic Functions of Wild-Type and Oncogenic IDH1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Coactivator SRC-2-dependent metabolic reprogramming mediates prostate cancer survival and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Arginine Methylation of SREBP1a via PRMT5 Promotes De Novo Lipogenesis and Tumor Growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G(1) cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Lipid synthetic transcription factor SREBP-1a activates p21WAF1/CIP1, a universal cyclin-dependent kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The phosphorylation-dependent regulation of nuclear SREBP1 during mitosis links lipid metabolism and cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Lipid metabolic reprogramming in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

A distinct function of the retinoblastoma protein in the control of lipid composition identified by lipidomic profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Endoplasmic reticulum stress impairs cholesterol efflux and synthesis in hepatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Does endoplasmic reticulum stress participate in APD-induced hepatic metabolic dysregulation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Gp78, an E3 ubiquitin ligase acts as a gatekeeper suppressing nonalcoholic steatohepatitis (NASH) and liver cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

n-3 Polyunsaturated fatty acids protect against pancreatic β-cell damage due to ER stress and prevent diabetes development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Signaling networks converge on TORC1-SREBP activity to promote endoplasmic reticulum homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Genome-wide analysis of SREBP-1 binding in mouse liver chromatin reveals a preference for promoter proximal binding to a new motif.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Protection from bacterial-toxin-induced apoptosis in macrophages requires the lipogenic transcription factor sterol regulatory element binding protein 1a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Activation and regulation of the inflammasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Evidence of contribution of iPLA2β-mediated events during islet β-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2β in T1D development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Regulation of Calcium-Independent Phospholipase A2 Expression by Adrenoceptors and Sterol Regulatory Element Binding Protein-Potential Crosstalk Between Sterol and Glycerophospholipid Mediators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

A guide to immunometabolism for immunologists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Perception of self: distinguishing autoimmunity from autoinflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Genome-wide analysis of SREBP1 activity around the clock reveals its combined dependency on nutrient and circadian signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Reprogramming of the circadian clock by nutritional challenge.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Time of day and nutrients in feeding govern daily expression rhythms of the gene for sterol regulatory element-binding protein (SREBP)-1 in the mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Circadian clock-coordinated 12 Hr period rhythmic activation of the IRE1alpha pathway controls lipid metabolism in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Casein kinase 1 delta regulates the pace of the mammalian circadian clock

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Ethanol and liver: recent insights into the mechanisms of ethanol-induced fatty liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The Hepatitis C Virus-induced NLRP3 Inflammasome Activates the Sterol Regulatory Element-binding Protein (SREBP) and Regulates Lipid Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Exogenous administration of DLK1 ameliorates hepatic steatosis and regulates gluconeogenesis via activation of AMPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Down-regulation of SREBP-1c is associated with the development of burned-out NASH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol regulatory element binding protein-1c expression of rat hepatic stellate cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The β-catenin pathway contributes to the effects of leptin on SREBP-1c expression in rat hepatic stellate cells and liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

PPARgamma in adipocyte differentiation and metabolism--novel insights from genome-wide studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

SREBP-1-independent regulation of lipogenic gene expression in adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Srebf1a is a key regulator of transcriptional control for adipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Transgenic mice overexpressing nuclear SREBP-1c in pancreatic beta-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a beta-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Suppression of the pancreatic duodenal homeodomain transcription factor-1 (Pdx-1) promoter by sterol regulatory element-binding protein-1c (SREBP-1c).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Stimulation of lipogenesis as well as fatty acid oxidation protects against palmitate-induced INS-1 beta-cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS‐1E beta‐cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Diabetes and insulin in regulation of brain cholesterol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

mTORC1 is essential for early steps during Schwann cell differentiation of amniotic fluid stem cells and regulates lipogenic gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Angiopoietins and diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Regulation of renal fatty acid and cholesterol metabolism, inflammation, and fibrosis in Akita and OVE26 mice with type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Regulation of renal lipid metabolism, lipid accumulation, and glomerulosclerosis in FVBdb/db mice with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Involvement of glomerular SREBP-1c in diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Role of sterol regulatory element-binding protein 1 in regulation of renal lipid metabolism and glomerulosclerosis in diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

SREBP-1 is a novel mediator of TGFβ1 signaling in mesangial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

MicroRNAs and lipid metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

MicroRNAs in metabolism and metabolic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Therapeutic Inhibition of miR-33 Promotes Fatty Acid Oxidation but Does Not Ameliorate Metabolic Dysfunction in Diet-Induced Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Molecular biology of PCSK9: its role in LDL metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Efficacy and safety of evolocumab in reducing lipids and cardiovascular events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Activation of mTORC1 disrupted LDL receptor pathway: a potential new mechanism for the progression of non-alcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Sterol Regulatory Element–Binding Protein-1 Determines Plasma Remnant Lipoproteins and Accelerates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Targeting SREBP-1-driven lipid metabolism to treat cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

SREBP activation by antipsychotic- and antidepressant-drugs in cultured human liver cells: relevance for metabolic side-effects?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Reducing LDL with PCSK9 Inhibitors--The Clinical Benefit of Lipid Drugs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2017.91

Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis

31 March 2020

1 reference

12 December 2020

Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice.

1 reference

12 December 2020

Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes

1 reference

12 December 2020

Novel delayed-early and highly insulin-induced growth response genes. Identification of HRS, a potential regulator of alternative pre-mRNA splicing

1 reference

12 December 2020

Cholesterol Contributes to Diabetic Nephropathy through SCAP-SREBP-2 Pathway

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRENDO.2017.91

1 reference

4 February 2018

1 reference

4 February 2018