(Q48613873)

English

Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice.

scientific article published on 20 July 2016

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scholarly article

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/27439389

Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice. (English)

1 reference

Europe PubMed Central

13 February 2018

http://europepmc.org/abstract/MED/27439389

amyotrophic lateral sclerosis

1 reference

based on heuristic

inferred from title

11

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11 June 2020

4

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11 June 2020

author name string

Shinji Hadano

1

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11 June 2020

Shun Mitsui

2

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11 June 2020

Lei Pan

3

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11 June 2020

Mizuki Kubo

5

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11 June 2020

Kai Sato

6

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11 June 2020

Suzuka Ono

7

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11 June 2020

Wakana Onodera

8

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11 June 2020

Koichiro Abe

9

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11 June 2020

XuePing Chen

10

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11 June 2020

Yasuo Uchiyama

12

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11 June 2020

Masashi Aoki

13

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11 June 2020

Eiji Warabi

14

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11 June 2020

Masayuki Yamamoto

15

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11 June 2020

Tetsuro Ishii

16

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11 June 2020

Toru Yanagawa

17

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11 June 2020

Hui-Fang Shang

18

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11 June 2020

Fumihito Yoshii

19

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11 June 2020

publication date

20 July 2016

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13 February 2018

http://europepmc.org/abstract/MED/27439389

Human Molecular Genetics

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11 June 2020

25

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11 June 2020

15

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11 June 2020

3321-3340

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11 June 2020

The changing scene of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

The genetics and neuropathology of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

State of play in amyotrophic lateral sclerosis genetics

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Amyotrophic lateral sclerosis models and human neuropathology: similarities and differences

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

The seeds of neurodegeneration: prion-like spreading in ALS

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Alsin/Rac1 signaling controls survival and growth of spinal motoneurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

SQSTM1 mutations in familial and sporadic amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Sporadic ALS with compound heterozygous mutations in the SQSTM1 gene.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Mutations in SQSTM1 encoding p62 in amyotrophic lateral sclerosis: genetics and neuropathology

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

SQSTM1 mutations in Han Chinese populations with sporadic amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Six SQSTM1 mutations in a Chinese amyotrophic lateral sclerosis cohort.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

p62 Deficiency Enhances α-Synuclein Pathology in Mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Absence of Nrf2 or its selective overexpression in neurons and muscle does not affect survival in ALS-linked mutant hSOD1 mouse models

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

The modest impact of transcription factor Nrf2 on the course of disease in an ALS animal model

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Onset and progression in inherited ALS determined by motor neurons and microglia

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Different human copper-zinc superoxide dismutase mutants, SOD1G93A and SOD1H46R, exert distinct harmful effects on gross phenotype in mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Degradation of Amyotrophic Lateral Sclerosis-linked Mutant Cu,Zn-Superoxide Dismutase Proteins by Macroautophagy and the Proteasome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Interaction of amyotrophic lateral sclerosis (ALS)-related mutant copper-zinc superoxide dismutase with the dynein-dynactin complex contributes to inclusion formation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Sequestosome1/p62: a regulator of redox-sensitive voltage-activated potassium channels, arterial remodeling, inflammation, and neurite outgrowth

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

p62 at the crossroads of autophagy, apoptosis, and cancer

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Oxidative stress and autophagy: the clash between damage and metabolic needs

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Secretory autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Absence of lipofuscin in motor neurons of SOD1-linked ALS mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Endolysosomal Deficits Augment Mitochondria Pathology in Spinal Motor Neurons of Asymptomatic fALS Mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

p62 plays a protective role in the autophagic degradation of polyglutamine protein oligomers in polyglutamine disease model flies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Exome sequencing reveals VCP mutations as a cause of familial ALS

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Mutations of optineurin in amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

The role of autophagy in neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Ubiquitination and selective autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Autophagy in neuronal cells: general principles and physiological and pathological functions

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

The Rab5 Activator ALS2/alsin Acts as a Novel Rac1 Effector through Rac1-activated Endocytosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Domain-specific mutations in sequestosome 1 (SQSTM1) cause familial and sporadic Paget's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

New ENU-induced semidominant mutation, Ali18, causes inflammatory arthritis, dermatitis, and osteoporosis in the mouse

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW180

21 January 2018

Identifiers

10.1093/HMG/DDW180

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27439389%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27439389%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

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