(Q50100385)

24 February 2018

title

Regulated intramembrane proteolysis: emergent role in cell signalling pathways. (English)

1 reference

24 February 2018

1 reference

Aonghus J McCarthy

1

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24 February 2018

Caroline Coleman-Vaughan

series ordinal

2

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24 February 2018

Justin V McCarthy

series ordinal

3

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24 February 2018

publication date

27 October 2017

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24 February 2018

Biochemical Society Transactions

published in

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24 February 2018

volume

45

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24 February 2018

issue

6

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24 February 2018

page(s)

1185-1202

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24 February 2018

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

cites work

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Sheddases and intramembrane-cleaving proteases: RIPpers of the membrane. Symposium on regulated intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Intramembrane proteolysis within lysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

A fast growing spectrum of biological functions of γ-secretase in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

The pathological significance of Notch1 in oral squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Clipping or Extracting: Two Ways to Membrane Protein Degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

The emerging role of proteolysis in mitochondrial quality control and the etiology of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Molecular mechanisms of soluble cytokine receptor generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Molecular and cellular mechanisms of ectodomain shedding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Many membrane proteins undergo ectodomain shedding by proteolytic cleavage. Does one sheddase do the job on all of these proteins?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Biochemical and structural insights into intramembrane metalloprotease mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Structure and function of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Purification and characterization of the human gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Active gamma-secretase complexes contain only one of each component

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Identification of distinct gamma-secretase complexes with different APH-1 variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Mechanism, specificity, and physiology of signal peptide peptidase (SPP) and SPP-like proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Visualization of specific γ-secretase complexes using bimolecular fluorescence complementation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Trafficking, a key player in regulated intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

The Notch signalling system: recent insights into the complexity of a conserved pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

TRAF6 promotes ubiquitination and regulated intramembrane proteolysis of IL-1R1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Association between Presenilin-1 and TRAF6 modulates regulated intramembrane proteolysis of the p75NTR neurotrophin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Gamma-secretase-independent role for cadherin-11 in neurotrophin receptor p75 (p75(NTR)) mediated glioblastoma cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Nuclear signalling by tumour-associated antigen EpCAM

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Clipping, shedding and RIPping keep immunity on cue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilin: RIP and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Initial activation of EpCAM cleavage via cell-to-cell contact

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Nuclear localization and possible functions of receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

The ErbB-4 s80 intracellular domain is a constitutively active tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Sequential processing of the transmembrane chemokines CX3CL1 and CXCL16 by alpha- and gamma-secretases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Characterization of sequential N-cadherin cleavage by ADAM10 and PS1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Mice lacking both presenilin genes exhibit early embryonic patterning defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Effect of presenilins in the apoptosis of thymocytes and homeostasis of CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilins regulate alphabeta T cell development by modulating TCR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Defective signal transduction in B lymphocytes lacking presenilin proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Loss of Presenilin 2 Function Is Associated with Defective LPS-Mediated Innate Immune Responsiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Toll-like receptors stimulate human neutrophil function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

γ-Secretase as a target for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Emerging roles for ectodomain shedding in the regulation of inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Matrix metalloproteinases as modulators of inflammation and innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

γ-secretase substrates and their implications for drug development in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Toll-like receptors expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic application

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

γ-Secretase component presenilin is important for microglia β-amyloid clearance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Cell fate decisions regulated by K63 ubiquitination of tumor necrosis factor receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Subcellular compartmentalization of TNF receptor-1 and CD95 signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

TNF-receptor I defective in internalization allows for cell death through activation of neutral sphingomyelinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Soluble interleukin-1 receptor type II levels are elevated in cerebrospinal fluid in Alzheimer's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Interleukin-6 and interleukin-11: same same but different

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilins are novel substrates for TRAF6-mediated ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Versatility of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Identification of new Presenilin-1 phosphosites: implication for γ-secretase activity and Aβ production

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

SEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilin modulates EGFR signaling and cell transformation by regulating the ubiquitin ligase Fbw7

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

TRAF6 stimulates the tumor-promoting effects of TGFβ type I receptor through polyubiquitination and activation of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

gamma-secretases: from cell biology to therapeutic strategies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

A function for monoubiquitination in the internalization of a G protein-coupled receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Linkage of the ubiquitin-conjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Growth factor receptor binding protein 2-mediated recruitment of the RING domain of Cbl to the epidermal growth factor receptor is essential and sufficient to support receptor endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Palmitoylation of the C-terminal fragment of p75(NTR) regulates death signaling and is required for subsequent cleavage by gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

GSK3beta activity modifies the localization and function of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

A cell biological perspective on Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Cargo recognition in clathrin-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Direct and potent regulation of gamma-secretase by its lipid microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Association of active gamma-secretase complex with lipid rafts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Active gamma-secretase is localized to detergent-resistant membranes in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Synaptic and endosomal localization of active gamma-secretase in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Assembly, trafficking and function of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Localisation and trafficking of Toll-like receptors: an important mode of regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Toll-like receptors stimulate regulated intramembrane proteolysis of the CSF-1 receptor through Erk activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Gamma-secretase-dependent proteolysis of CD44 promotes neoplastic transformation of rat fibroblastic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilin/gamma-secretase and alpha-secretase-like peptidases cleave human MHC Class I proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Structure of the Extracellular Portion of CD46 Provides Insights into Its Interactions with Complement Proteins and Pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Regulation of ApoE receptor proteolysis by ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Low-affinity nerve-growth factor receptor (P75NTR) can serve as a receptor for rabies virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20170002

21 January 2018

Identifiers

DOI

10.1042/BST20170002

1 reference

24 February 2018

PubMed ID

29079648

1 reference

24 February 2018