(Q53129605)

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Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.

scientific article published on 15 January 2013

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase. (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

Peer-Hendrik Kuhn

3

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

Stefan F Lichtenthaler

5

object named as

Stefan F Lichtenthaler

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

Christian Haass

6

object named as

Christian Haass

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

author name string

Benedikt Kretner

1

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

Akio Fukumori

2

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

Blanca Isabel Pérez-Revuelta

4

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

Harald Steiner

7

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

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publication date

15 January 2013

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

number of pages

13

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Journal of Neurochemistry

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

125

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

1

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

144-156

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Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.

1 reference

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21 January 2018

Notch signalling: a simple pathway becomes complex

1 reference

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21 January 2018

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity

1 reference

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21 January 2018

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

1 reference

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21 January 2018

Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease

1 reference

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21 January 2018

Glu-333 of nicastrin directly participates in gamma-secretase activity

1 reference

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21 January 2018

Reconstitution of gamma-secretase activity

1 reference

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21 January 2018

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

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21 January 2018

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis

1 reference

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21 January 2018

Mutation Analysis of the Presenilin 1 N-terminal Domain Reveals a Broad Spectrum of γ-Secretase Activity toward Amyloid Precursor Protein and Other Substrates

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21 January 2018

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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21 January 2018

Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer’s disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure

1 reference

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21 January 2018

Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements

1 reference

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21 January 2018

The crystal structure of GXGD membrane protease FlaK

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21 January 2018

γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes

1 reference

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21 January 2018

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

1 reference

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21 January 2018

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

1 reference

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21 January 2018

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region

1 reference

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21 January 2018

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

1 reference

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21 January 2018

Identification of function for CD44 intracytoplasmic domain (CD44-ICD): modulation of matrix metalloproteinase 9 (MMP-9) transcription via novel promoter response element

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Beta-amyloid precursor protein mutants respond to gamma-secretase modulators

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Potent amyloidogenicity and pathogenicity of Aβ43.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

On the size of the active site in proteases. I. Papain

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Nicastrin functions as a gamma-secretase-substrate receptor

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Structural investigation of the C-terminal catalytic fragment of presenilin 1

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

The catalytic core of gamma-secretase: presenilin revisited

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Intramembrane proteolysis by gamma-secretase

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Secretase inhibitors and modulators for Alzheimer's disease treatment

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Intramembrane-cleaving proteases

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Novel gamma-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies

1 reference

https://api.crossref.org/works/10.1111%2FJNC.12124

21 January 2018

Identifiers

10.1111/JNC.12124

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 May 2018

http://europepmc.org/abstract/MED/23237322

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