(Q64084217)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30884855%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

2 references

26 August 2020

8 February 2021

Drugging the Small GTPase Pathways in Cancer Treatment: Promises and Challenges (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30884855%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

1 reference

26 August 2020

1 reference

8 February 2021

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30884855%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

author name string

Néstor Prieto-Dominguez

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30884855%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

Christopher Parnell

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30884855%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

language of work or name

English

0 references

publication date

16 March 2019

3 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30884855%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

26 August 2020

8 February 2021

3 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30884855%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

26 August 2020

8 February 2021

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30884855%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30884855%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution

29 April 2020

page(s)

255

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copyright license

2 references

26 August 2020

8 February 2021

0 references

Ras oncoprotein inhibitors: the discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex

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12 December 2020

Bisphosphonates inhibit prostate and breast carcinoma cell adhesion to unmineralized and mineralized bone extracellular matrices.

1 reference

12 December 2020

Sulindac sulfide inhibits Ras signaling

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12 December 2020

Interaction of a novel GDP exchange inhibitor with the Ras protein

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12 December 2020

Snapshots of ARF1: implications for mechanisms of activation and inactivation

1 reference

12 December 2020

Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases

1 reference

12 December 2020

Paxillin interactions

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12 December 2020

Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers

1 reference

12 December 2020

Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues.

1 reference

12 December 2020

Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

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12 December 2020

Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism

1 reference

12 December 2020

The novel Ras antagonist, farnesylthiosalicylate, suppresses growth of prostate cancer in vitro

1 reference

12 December 2020

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

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12 December 2020

The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras

1 reference

12 December 2020

Human RAS superfamily proteins and related GTPases

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12 December 2020

Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice

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12 December 2020

The Ras superfamily at a glance

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12 December 2020

Aberrant expression of RAB1A in human tongue cancer.

1 reference

12 December 2020

Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells

1 reference

12 December 2020

A novel mechanism for the modulation of the Ras-effector interaction by small molecules

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12 December 2020

Design, synthesis and biological evaluation of sugar-derived Ras inhibitors

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12 December 2020

Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro.

1 reference

12 December 2020

Dual specificity of the interfacial inhibitor brefeldin a for arf proteins and sec7 domains

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12 December 2020

Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells.

1 reference

12 December 2020

Semaphorin 4D/Plexin-B1-mediated R-Ras GAP activity inhibits cell migration by regulating beta(1) integrin activity

1 reference

12 December 2020

Synthesis and anticancer activity of brefeldin A ester derivatives

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12 December 2020

Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance

1 reference

12 December 2020

Molecular mechanism of the nuclear protein import cycle

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12 December 2020

Large scale synthesis of the Cdc42 inhibitor secramine A and its inhibition of cell spreading

1 reference

12 December 2020

In vitro and in vivo synergy of MCP compounds with mitogen-activated protein kinase pathway- and microtubule-targeting inhibitors

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12 December 2020

Fibrolamellar carcinomas show overexpression of genes in the RAS, MAPK, PIK3, and xenobiotic degradation pathways

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12 December 2020

Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid).

1 reference

12 December 2020

Orally administered FTS (salirasib) inhibits human pancreatic tumor growth in nude mice

1 reference

12 December 2020

Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.

1 reference

12 December 2020

Non-steroidal anti-inflammatory drugs suppress the ERK signaling pathway via block of Ras/c-Raf interaction and activation of MAP kinase phosphatases

1 reference

12 December 2020

The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network.

1 reference

12 December 2020

An Arf1 GTPase mutant with different responses to GEF inhibitors

1 reference

12 December 2020

Affinity-based labeling of cytohesins with a bifunctional SecinH3 photoaffinity probe

1 reference

12 December 2020

The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation

1 reference

12 December 2020

Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo

1 reference

12 December 2020

Ran on tracks--cytoplasmic roles for a nuclear regulator

1 reference

12 December 2020

Rho GTPase function in tumorigenesis

1 reference

12 December 2020

Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse.

1 reference

12 December 2020

First experimental identification of Ras-inhibitor binding interface using a water-soluble Ras ligand.

1 reference

12 December 2020

Rab GTPases as coordinators of vesicle traffic

1 reference

12 December 2020

Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes

1 reference

12 December 2020

Rab5a overexpression promoting ovarian cancer cell proliferation may be associated with APPL1-related epidermal growth factor signaling pathway

1 reference

12 December 2020

Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis

1 reference

12 December 2020

Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition

1 reference

12 December 2020

Signaling mechanisms of inhibition of phospholipase D activation by CHS-111 in formyl peptide-stimulated neutrophils.

1 reference

12 December 2020

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

1 reference

12 December 2020

Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer

1 reference

12 December 2020

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

1 reference

12 December 2020

Integrin-mediated function of Rab GTPases in cancer progression

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12 December 2020

Novel inhibitors of Rac1 in metastatic breast cancer.

1 reference

12 December 2020

Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 β-cells and rat islets.

1 reference

12 December 2020

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis.

1 reference

12 December 2020

The diverse roles of Rac signaling in tumorigenesis

1 reference

12 December 2020

Ras family small GTPase-mediated neuroprotective signaling in stroke

1 reference

12 December 2020

HIV-1 activates Cdc42 and induces membrane extensions in immature dendritic cells to facilitate cell-to-cell virus propagation

1 reference

12 December 2020

ARF family G proteins and their regulators: roles in membrane transport, development and disease.

1 reference

12 December 2020

Early requirement of Rac1 in a mouse model of pancreatic cancer.

1 reference

12 December 2020

An orthosteric inhibitor of the Ras-Sos interaction

1 reference

12 December 2020

Regulation of small GTPases at epithelial cell-cell junctions

1 reference

12 December 2020

An Exo2 derivative affects ER and Golgi morphology and vacuolar sorting in a tissue-specific manner in arabidopsis

1 reference

12 December 2020

Regulating Rap small G-proteins in time and space

1 reference

12 December 2020

The antitumor effect of a novel angiogenesis inhibitor (an octahydronaphthalene derivative) targeting both VEGF receptor and NF-κB pathway

1 reference

12 December 2020

A phase II trial of Salirasib in patients with lung adenocarcinomas with KRAS mutations

1 reference

12 December 2020

Insights into the classification of small GTPases

1 reference

12 December 2020

Targeting protein prenylation for cancer therapy

1 reference

12 December 2020

AMF-26, a novel inhibitor of the Golgi system, targeting ADP-ribosylation factor 1 (Arf1) with potential for cancer therapy.

1 reference

12 December 2020

Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

1 reference

12 December 2020

Ras family of small GTPases in immunity and inflammation

1 reference

12 December 2020

Protein kinase C δ regulates the release of collagen type I from vascular smooth muscle cells via regulation of Cdc42.

1 reference

12 December 2020

The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer

1 reference

12 December 2020

Integrated preclinical and clinical development of S-trans, trans-Farnesylthiosalicylic Acid (FTS, Salirasib) in pancreatic cancer

1 reference

12 December 2020

The association between CDC42 and caveolin-1 is involved in the regulation of capacitation and acrosome reaction of guinea pig and mouse sperm

1 reference

12 December 2020

Targeting of Rac GTPases blocks the spread of intact human breast cancer.

1 reference

12 December 2020

Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting

1 reference

12 December 2020

Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

1 reference

12 December 2020

BART inhibits pancreatic cancer cell invasion by Rac1 inactivation through direct binding to active Rac1.

1 reference

12 December 2020

Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells

1 reference

12 December 2020

Ras inhibition via direct Ras binding--is there a path forward?

1 reference

12 December 2020

Novel functions for Rab GTPases in multiple aspects of tumour progression

1 reference

12 December 2020

Total synthesis of AMF-26, an antitumor agent for inhibition of the Golgi system, targeting ADP-ribosylation factor 1.

1 reference

12 December 2020

Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility

1 reference

12 December 2020

Regulation of small GTPases by GEFs, GAPs, and GDIs

1 reference

12 December 2020

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors

1 reference

12 December 2020

Characterization of a Cdc42 protein inhibitor and its use as a molecular probe

1 reference

12 December 2020

A novel anti-CCN1 monoclonal antibody suppresses Rac-dependent cytoskeletal reorganization and migratory activities in breast cancer cells

1 reference

12 December 2020

Synthesis and cytotoxic evaluation of acylated brefeldin a derivatives as potential anticancer agents.

1 reference

12 December 2020

RNA aptamers and their therapeutic and diagnostic applications

1 reference

12 December 2020

RNA-aptamers that modulate the RhoGEF activity of Tiam1.

1 reference

12 December 2020

Rit subfamily small GTPases: regulators in neuronal differentiation and survival

1 reference

12 December 2020

Synthesis and biological properties of novel brefeldin A analogues

1 reference

12 December 2020

Activation of Rho GTPase Cdc42 promotes adhesion and invasion in colorectal cancer cells

1 reference

12 December 2020

Targeting Cdc42 in cancer

1 reference

12 December 2020

A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice

1 reference

12 December 2020

Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro

1 reference

12 December 2020

Pak and Rac GTPases promote oncogenic KIT-induced neoplasms

1 reference

12 December 2020

Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists

1 reference

12 December 2020

The Ras superfamily of small GTPases: the unlocked secrets

1 reference

12 December 2020

Targeting Rho-GTPases in immune cell migration and inflammation

1 reference

12 December 2020

Cytohesins/ARNO: the function in colorectal cancer cells

1 reference

12 December 2020

RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer

1 reference

12 December 2020

Rho GTPases: masters of cell migration

1 reference

12 December 2020

A two-hybrid approach to identify inhibitors of the RAS-RAF interaction

1 reference

12 December 2020

Down-regulation of Ras-related protein Rab 5C-dependent endocytosis and glycolysis in cisplatin-resistant ovarian cancer cell lines

1 reference

12 December 2020

Chemical biology tools for regulating RAS signaling complexity in space and time

1 reference

12 December 2020

The role of the RhoA/Rho kinase pathway in angiogenesis and its potential value in prostate cancer (Review).

1 reference

12 December 2020

Drugging the undruggable RAS: Mission possible?

1 reference

12 December 2020

Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation

1 reference

12 December 2020

The myriad roles of Miro in the nervous system: axonal transport of mitochondria and beyond

1 reference

12 December 2020

The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model

1 reference

12 December 2020

Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions

1 reference

12 December 2020

ARF1 regulates adhesion of MDA-MB-231 invasive breast cancer cells through formation of focal adhesions

1 reference

12 December 2020

Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

1 reference

12 December 2020

Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets.

1 reference

12 December 2020

The Arf GTPase-activating protein family is exploited by Salmonella enterica serovar Typhimurium to invade nonphagocytic host cells

1 reference

12 December 2020

Cdc42: Role in Cancer Management

1 reference

12 December 2020

Rab40b upregulation correlates with the prognosis of gastric cancer by promoting migration, invasion, and metastasis

1 reference

12 December 2020

Ral GTPases: crucial mediators of exocytosis and tumourigenesis

1 reference

12 December 2020

Approaches of targeting Rho GTPases in cancer drug discovery

1 reference

12 December 2020

Brefeldin A exerts differential effects on anaplastic lymphoma kinase positive anaplastic large cell lymphoma and classical Hodgkin lymphoma cell lines

1 reference

12 December 2020

Predominant Rab-GTPase amplicons contributing to oral squamous cell carcinoma progression to metastasis

1 reference

12 December 2020

Neuroglobin Plays a Protective Role in Arsenite-Induced Cytotoxicity by Inhibition of Cdc42 and Rac1GTPases in Rat Cerebellar Granule Neurons

1 reference

12 December 2020

Rap2B promotes proliferation, migration, and invasion of human breast cancer through calcium-related ERK1/2 signaling pathway

1 reference

12 December 2020

R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis

1 reference

12 December 2020

VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.

1 reference

12 December 2020

Rac1 and Cdc42 Play Important Roles in Arsenic Neurotoxicity in Primary Cultured Rat Cerebellar Astrocytes

1 reference

12 December 2020

Rheb signaling and tumorigenesis: mTORC1 and new horizons

1 reference

12 December 2020

The perilipin-2 (adipophilin) coat of cytosolic lipid droplets is regulated by an Arf1-dependent mechanism in HC11 mouse mammary epithelial cells.

1 reference

12 December 2020

Direct Modulation of Small GTPase Activity and Function

1 reference

12 December 2020

Chemotherapy Resistance in Diffuse-Type Gastric Adenocarcinoma Is Mediated by RhoA Activation in Cancer Stem-Like Cells

1 reference

12 December 2020

Inhibitors of Ras-SOS Interactions

1 reference

12 December 2020

Endothelial Robo4 suppresses breast cancer growth and metastasis through regulation of tumor angiogenesis

1 reference

12 December 2020

Pharmacological modulation of oncogenic Ras by natural products and their derivatives: Renewed hope in the discovery of novel anti-Ras drugs.

1 reference

12 December 2020

M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers

1 reference

12 December 2020

ARF1 promotes prostate tumorigenesis via targeting oncogenic MAPK signaling.

1 reference

12 December 2020

M-COPA, a novel Golgi system disruptor, suppresses apoptosis induced by Shiga toxin

1 reference

12 December 2020

Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1.

1 reference

12 December 2020

Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors

1 reference

12 December 2020

Integrin-α10 Dependency Identifies RAC and RICTOR as Therapeutic Targets in High-Grade Myxofibrosarcoma.

1 reference

12 December 2020

Arf proteins in cancer cell migration.

1 reference

12 December 2020

Rab14 is overexpressed in ovarian cancers and promotes ovarian cancer proliferation through Wnt pathway.

1 reference

12 December 2020

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

1 reference

12 December 2020

M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells.

1 reference

12 December 2020

Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.

1 reference

12 December 2020

Roles of Arf6 in cancer cell invasion, metastasis and proliferation

1 reference

12 December 2020

Targeting metabolic reprogramming in KRAS-driven cancers

1 reference

12 December 2020

Targeting the α4-α5 interface of RAS results in multiple levels of inhibition.

1 reference

12 December 2020

An engineered protein antagonist of K-Ras/B-Raf interaction

1 reference

12 December 2020

Combined targeting of Arf1 and Ras potentiates anticancer activity for prostate cancer therapeutics.

1 reference

12 December 2020

Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice

1 reference

12 December 2020

Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound.

1 reference

12 December 2020

Rab25 GTPase: Functional roles in cancer

1 reference

12 December 2020

Knockdown of Ran GTPase expression inhibits the proliferation and migration of breast cancer cells.

1 reference

12 December 2020

A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling

1 reference

12 December 2020

Histone deacetylase inhibitors suppress aggressiveness of head and neck squamous cell carcinoma via histone acetylation-independent blockade of the EGFR-Arf1 axis

1 reference

12 December 2020

Identifiers

DOI

10.3390/CELLS8030255

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30884855%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30884855%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

PubMed publication ID

30884855

1 reference