(Q64286784)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30737084%20AND%20SRC:MED&resulttype=core&format=json

22 April 2020

1 reference

8 February 2021

Senolytics and senostatics as adjuvant tumour therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30737084%20AND%20SRC:MED&resulttype=core&format=json

22 April 2020

0 references

0 references

1 reference

8 February 2021

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30737084%20AND%20SRC:MED&resulttype=core&format=json

22 April 2020

Thomas von Zglinicki

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30737084%20AND%20SRC:MED&resulttype=core&format=json

22 April 2020

author name string

Susan Short

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30737084%20AND%20SRC:MED&resulttype=core&format=json

22 April 2020

Edward Fielder

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30737084%20AND%20SRC:MED&resulttype=core&format=json

22 April 2020

language of work or name

English

0 references

publication date

6 February 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30737084%20AND%20SRC:MED&resulttype=core&format=json

22 April 2020

1 March 2019

1 reference

8 February 2021

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30737084%20AND%20SRC:MED&resulttype=core&format=json

22 April 2020

8 February 2021

41

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30737084%20AND%20SRC:MED&resulttype=core&format=json

22 April 2020

page(s)

683-692

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30737084%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

22 April 2020

copyright license

1 reference

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging

8 February 2021

cites work

1 reference

12 December 2020

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

1 reference

12 December 2020

The serial cultivation of human diploid cell strains

1 reference

12 December 2020

Health Status of Adult Long-term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

1 reference

12 December 2020

A DNA damage checkpoint response in telomere-initiated senescence

1 reference

12 December 2020

Human cell senescence as a DNA damage response.

1 reference

12 December 2020

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

1 reference

12 December 2020

Relative fracture risk in patients with diabetes mellitus, and the impact of insulin and oral antidiabetic medication on relative fracture risk

1 reference

12 December 2020

Tumour biology: senescence in premalignant tumours

1 reference

12 December 2020

Oncogene-Induced Senescence: Putting the Brakes on Tumor Development

1 reference

12 December 2020

Oncogene-induced cell senescence--halting on the road to cancer

1 reference

12 December 2020

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

1 reference

12 December 2020

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

1 reference

12 December 2020

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

1 reference

12 December 2020

Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

1 reference

12 December 2020

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.

1 reference

12 December 2020

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

1 reference

12 December 2020

Brain tumor stem cells: bringing order to the chaos of brain cancer

1 reference

12 December 2020

Chemokine signaling via the CXCR2 receptor reinforces senescence

1 reference

12 December 2020

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network

1 reference

12 December 2020

Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

1 reference

12 December 2020

Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: long-term follow-up.

1 reference

12 December 2020

Feedback between p21 and reactive oxygen production is necessary for cell senescence

1 reference

12 December 2020

Adult-onset, short-term dietary restriction reduces cell senescence in mice.

1 reference

12 December 2020

Therapy-induced senescence in cancer

1 reference

12 December 2020

Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice

1 reference

12 December 2020

Four faces of cellular senescence.

1 reference

12 December 2020

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

1 reference

12 December 2020

Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients

1 reference

12 December 2020

Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer's hierarchy

1 reference

12 December 2020

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

1 reference

12 December 2020

Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling

1 reference

12 December 2020

A senescent cell bystander effect: senescence-induced senescence

1 reference

12 December 2020

Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy

1 reference

12 December 2020

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

1 reference

12 December 2020

Effects of a caloric restriction weight loss diet and exercise on inflammatory biomarkers in overweight/obese postmenopausal women: a randomized controlled trial

1 reference

12 December 2020

Enhanced cytotoxic effect of low doses of metformin combined with ionizing radiation on hepatoma cells via ATP deprivation and inhibition of DNA repair

1 reference

12 December 2020

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

1 reference

12 December 2020

Polyploidy road to therapy-induced cellular senescence and escape.

1 reference

12 December 2020

Metformin use and improved response to therapy in esophageal adenocarcinoma

1 reference

12 December 2020

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

1 reference

12 December 2020

Fasting enhances the response of glioma to chemo- and radiotherapy

1 reference

12 December 2020

Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors

1 reference

12 December 2020

Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model

1 reference

12 December 2020

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

1 reference

12 December 2020

Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK.

1 reference

12 December 2020

Senescent fibroblasts enhance early skin carcinogenic events via a paracrine MMP-PAR-1 axis.

1 reference

12 December 2020

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

1 reference

12 December 2020

Metformin improves healthspan and lifespan in mice

1 reference

12 December 2020

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

1 reference

12 December 2020

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

1 reference

12 December 2020

Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway.

1 reference

12 December 2020

Metformin use and improved response to therapy in rectal cancer

1 reference

12 December 2020

Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response

1 reference

12 December 2020

Physiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: a report from the St Jude Lifetime cohort study

1 reference

12 December 2020

Metformin limits ceramide-induced senescence in C2C12 myoblasts

1 reference

12 December 2020

Senescent cells harbour features of the cancer epigenome.

1 reference

12 December 2020

Survivors of childhood and adolescent cancer: life-long risks and responsibilities.

1 reference

12 December 2020

Low and high linear energy transfer radiation sensitization of HCC cells by metformin

1 reference

12 December 2020

Calories, carbohydrates, and cancer therapy with radiation: exploiting the five R's through dietary manipulation

1 reference

12 December 2020

Long-term metformin usage and cognitive function among older adults with diabetes.

1 reference

12 December 2020

Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers

1 reference

12 December 2020

Male mice retain a metabolic memory of improved glucose tolerance induced during adult onset, short-term dietary restriction

1 reference

12 December 2020

Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner

1 reference

12 December 2020

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.

1 reference

12 December 2020

Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders

1 reference

12 December 2020

Dynamic modelling of pathways to cellular senescence reveals strategies for targeted interventions

1 reference

12 December 2020

Metformin inhibits the growth of nasopharyngeal carcinoma cells and sensitizes the cells to radiation via inhibition of the DNA damage repair pathway

1 reference

12 December 2020

Relationship between metformin and frailty syndrome in elderly people with type 2 diabetes

1 reference

12 December 2020

Roles of caloric restriction, ketogenic diet and intermittent fasting during initiation, progression and metastasis of cancer in animal models: a systematic review and meta-analysis

1 reference

12 December 2020

Frailty Attenuates the Impact of Metformin on Reducing Mortality in Older Adults with Type 2 Diabetes

1 reference

12 December 2020

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.

1 reference

12 December 2020

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

1 reference

12 December 2020

The effects of graded levels of calorie restriction: I. impact of short term calorie and protein restriction on body composition in the C57BL/6 mouse

1 reference

12 December 2020

A weighty problem: metabolic perturbations and the obesity-cancer link

1 reference

12 December 2020

DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease.

1 reference

12 December 2020

Treatment Rationale and Study Design for the JUNIPER Study: A Randomized Phase III Study of Abemaciclib With Best Supportive Care Versus Erlotinib With Best Supportive Care in Patients With Stage IV Non–Small-Cell Lung Cancer With a Detectable KRAS

1 reference

12 December 2020

Metformin Use Is Associated With Better Survival of Breast Cancer Patients With Diabetes: A Meta-Analysis

1 reference

12 December 2020

Effects of metformin on survival outcomes of lung cancer patients with type 2 diabetes mellitus: a meta-analysis

1 reference

12 December 2020

Years of potential life lost for brain and CNS tumors relative to other cancers in adults in the United States, 2010.

1 reference

12 December 2020

Therapy-Induced Cellular Senescence Induces Epithelial-to-Mesenchymal Transition and Increases Invasiveness in Rectal Cancer

1 reference

12 December 2020

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

1 reference

12 December 2020

Targeting senescent cells enhances adipogenesis and metabolic function in old age

1 reference

12 December 2020

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

1 reference

12 December 2020

Mitochondria are required for pro-ageing features of the senescent phenotype.

1 reference

12 December 2020

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.

1 reference

12 December 2020

Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence

1 reference

12 December 2020

Metformin therapy associated with survival benefit in lung cancer patients with diabetes

1 reference

12 December 2020

Physiologic Frailty in Nonelderly Hematopoietic Cell Transplantation Patients: Results From the Bone Marrow Transplant Survivor Study

1 reference

12 December 2020

Metformin as a Tool to Target Aging

1 reference

12 December 2020

Anticipating the "Silver Tsunami": Prevalence Trajectories and Comorbidity Burden among Older Cancer Survivors in the United States

1 reference

12 December 2020

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

1 reference

12 December 2020

Moving the needle: Optimizing classification for glioma

1 reference

12 December 2020

NOTCH1 mediates a switch between two distinct secretomes during senescence.

1 reference

12 December 2020

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.

1 reference

12 December 2020

TGFΒ-induced transcription in cancer

1 reference

12 December 2020

The radioprotective effect of metformin against cytotoxicity and genotoxicity induced by ionizing radiation in cultured human blood lymphocytes.

1 reference

12 December 2020

Elimination of p19(ARF)-expressing cells enhances pulmonary function in mice.

1 reference

12 December 2020

Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression

1 reference

12 December 2020

Autophagy deficient melanocytes display a senescence associated secretory phenotype that includes oxidized lipid mediators

1 reference

12 December 2020

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

1 reference

12 December 2020

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy.

1 reference

12 December 2020

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.

1 reference

12 December 2020

Cancer Statistics, 2017.

1 reference

12 December 2020

Differential effects of metformin on age related comorbidities in older men with type 2 diabetes

1 reference

12 December 2020

Cellular senescence mediates fibrotic pulmonary disease

1 reference

12 December 2020

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?

1 reference

12 December 2020

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

1 reference

12 December 2020

Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism

1 reference

12 December 2020

DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age.

1 reference

12 December 2020

Cellular Senescence: A Translational Perspective

1 reference

12 December 2020

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

1 reference

12 December 2020

Metformin is associated with survival benefit in pancreatic cancer patients with diabetes: a systematic review and meta-analysis

1 reference

12 December 2020

CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2009-2013.

1 reference

12 December 2020

Inhibition of Bcl-2/xl With ABT-263 Selectively Kills Senescent Type II Pneumocytes and Reverses Persistent Pulmonary Fibrosis Induced by Ionizing Radiation in Mice.

1 reference

12 December 2020

Cellular senescence drives age-dependent hepatic steatosis.

1 reference

12 December 2020

Effects of bioactive compounds on senescence and components of senescence associated secretory phenotypes in vitro

1 reference

12 December 2020

Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis.

1 reference

12 December 2020

The senescent bystander effect is caused by ROS-activated NF-κB signalling

1 reference

12 December 2020

Identification of HSP90 inhibitors as a novel class of senolytics.

1 reference

12 December 2020

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer.

1 reference

12 December 2020

Some chemotherapeutics-treated colon cancer cells display a specific phenotype being a combination of stem-like and senescent cell features.

1 reference

12 December 2020

Emerging role of extracellular vesicles as a senescence-associated secretory phenotype: Insights into the pathophysiology of lung diseases

1 reference

12 December 2020

Metformin use and survival of lung cancer patients: Meta-analysis findings.

1 reference

12 December 2020

Senescence-associated reprogramming promotes cancer stemness.

1 reference

12 December 2020

Biology of premature ageing in survivors of cancer.

1 reference

12 December 2020

Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy.

1 reference

12 December 2020

Two-Step Senescence-Focused Cancer Therapies

1 reference

12 December 2020

Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype.

1 reference

12 December 2020

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy.

1 reference

12 December 2020

Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer.

1 reference

12 December 2020

Senolytics improve physical function and increase lifespan in old age

1 reference

12 December 2020

Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy

1 reference

12 December 2020

Elimination of p19ARF -expressing cells protects against pulmonary emphysema in mice

1 reference

12 December 2020

Evolution of survivorship in lymphoma, myeloma and leukemia: Metamorphosis of the field into long term follow-up care

1 reference

12 December 2020

Senescence and senotherapeutics: a new field in cancer therapy

1 reference

12 December 2020

Cellular Senescence: The Sought or the Unwanted?

1 reference

12 December 2020

Survival Benefit of Metformin Adjuvant Treatment For Pancreatic Cancer Patients: a Systematic Review and Meta-Analysis

1 reference

12 December 2020

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

1 reference

12 December 2020

Cytosolic DNA Sensing in Organismal Tumor Control

1 reference

12 December 2020

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

1 reference

12 December 2020

The Senescence-Stemness Alliance - A Cancer-Hijacked Regeneration Principle

1 reference

12 December 2020

Fisetin is a senotherapeutic that extends health and lifespan

1 reference

12 December 2020

Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer

1 reference

12 December 2020

The bystander effect contributes to the accumulation of senescent cells in vivo

1 reference

12 December 2020

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

1 reference

12 December 2020

The dynamic nature of senescence in cancer

1 reference

12 December 2020

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

1 reference

12 December 2020

10.1016/J.EBIOM.2019.01.056

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30737084%20AND%20SRC:MED&resulttype=core&format=json

22 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30737084%20AND%20SRC:MED&resulttype=core&format=json

22 April 2020

1 reference