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The dynamic nature of senescence in cancer
scientific article published on 02 January 2019
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Europe PubMed Central
PubMed publication ID
30602768
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30602768%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 April 2020
title
The dynamic nature of senescence in cancer
(English)
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stated in
Europe PubMed Central
PubMed publication ID
30602768
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30602768%20AND%20SRC:MED&resulttype=core&format=json
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16 April 2020
author
Clemens A Schmitt
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2
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Europe PubMed Central
PubMed publication ID
30602768
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30602768%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 April 2020
Soyoung Lee
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Soyoung Lee
1 reference
stated in
Europe PubMed Central
PubMed publication ID
30602768
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30602768%20AND%20SRC:MED&resulttype=core&format=json
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16 April 2020
publication date
2 January 2019
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Europe PubMed Central
PubMed publication ID
30602768
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30602768%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 April 2020
published in
Nature Cell Biology
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stated in
Europe PubMed Central
PubMed publication ID
30602768
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30602768%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 April 2020
volume
21
1 reference
stated in
Europe PubMed Central
PubMed publication ID
30602768
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30602768%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 April 2020
issue
1
1 reference
stated in
Europe PubMed Central
PubMed publication ID
30602768
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30602768%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 April 2020
page(s)
94-101
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stated in
Europe PubMed Central
PubMed publication ID
30602768
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30602768%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 April 2020
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Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci
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Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence
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Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
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HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia
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BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance
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Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.
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DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
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Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer
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Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway
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Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways.
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Chemokine signaling via the CXCR2 receptor reinforces senescence
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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
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STING manifests self DNA-dependent inflammatory disease
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cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.
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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
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Cell fusion induced by ERVWE1 or measles virus causes cellular senescence
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Senescent cells communicate via intercellular protein transfer
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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging
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Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS)
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p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes
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Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
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A complex secretory program orchestrated by the inflammasome controls paracrine senescence
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Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression
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Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.
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The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance
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T-helper-1-cell cytokines drive cancer into senescence
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High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer
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Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo
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Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors
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Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed-Sternberg cells
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A Senescence-Inflammatory Switch from Cancer-Inhibitory to Cancer-Promoting Mechanism
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Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors
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based on heuristic
inferred from DOI database lookup
Unmasking Transcriptional Heterogeneity in Senescent Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
histoCAT: analysis of cell phenotypes and interactions in multiplex image cytometry data.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genome-wide chromatin state transitions associated with developmental and environmental cues
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Programmed cell senescence during mammalian embryonic development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Senescence is a developmental mechanism that contributes to embryonic growth and patterning
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BRAFE600-associated senescence-like cell cycle arrest of human naevi
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular senescence predicts treatment outcome in metastasised colorectal cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Evasion of Cell Senescence Leads to Medulloblastoma Progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Senescence impairs successful reprogramming to pluripotent stem cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Ink4/Arf locus is a barrier for iPS cell reprogramming
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Senescent cells harbour features of the cancer epigenome.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oncogene-induced senescence as an initial barrier in lymphoma development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumour biology: senescence in premalignant tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting cellular senescence prevents age-related bone loss in mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
UnSASPing Senescence: Unmasking Tumor Suppression?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pro-senescence therapy for cancer treatment
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular Senescence: A Translational Perspective
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Spatial coupling of mTOR and autophagy augments secretory phenotypes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autophagy mediates the mitotic senescence transition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Senescence-associated exosome release from human prostate cancer cells.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41556-018-0249-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/S41556-018-0249-2
1 reference
stated in
Europe PubMed Central
PubMed publication ID
30602768
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30602768%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 April 2020
PubMed publication ID
30602768
1 reference
stated in
Europe PubMed Central
PubMed publication ID
30602768
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30602768%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 April 2020
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