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Targeting mitochondria for cancer therapy
scientific article published on 01 June 2010
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
20213841
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213841%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 January 2020
review article
1 reference
stated in
Europe PubMed Central
title
Targeting mitochondria for cancer therapy
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
20213841
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213841%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 January 2020
author
David Hockenbery
series ordinal
1
object named as
David M Hockenbery
1 reference
stated in
Europe PubMed Central
PubMed ID
20213841
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213841%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 January 2020
publication date
1 June 2010
1 reference
stated in
Europe PubMed Central
PubMed ID
20213841
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213841%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 January 2020
published in
Environmental and Molecular Mutagenesis
1 reference
stated in
Europe PubMed Central
PubMed ID
20213841
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213841%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 January 2020
volume
51
1 reference
stated in
Europe PubMed Central
PubMed ID
20213841
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213841%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 January 2020
issue
5
1 reference
stated in
Europe PubMed Central
PubMed ID
20213841
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213841%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 January 2020
page(s)
476-489
1 reference
stated in
Europe PubMed Central
PubMed ID
20213841
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213841%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 January 2020
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HL-A antigens in adult polymyositis
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MYC-induced cancer cell energy metabolism and therapeutic opportunities
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Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.
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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.
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Reduction in new metastases in breast cancer with adjuvant clodronate treatment
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Metformin and reduced risk of cancer in diabetic patients
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A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.
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BH3-domain mimetic compound BH3I-2' induces rapid damage to the inner mitochondrial membrane prior to the cytochrome c release from mitochondria.
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BH3-Only proteins-essential initiators of apoptotic cell death
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Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
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Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A.
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Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2
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Bcl-XL Mutations Suppress Cellular Sensitivity to Antimycin A
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7 January 2021
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7 January 2021
based on heuristic
inferred from DOI database lookup
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7 January 2021
based on heuristic
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7 January 2021
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7 January 2021
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7 January 2021
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based on heuristic
inferred from DOI database lookup
DNA intercalating compounds as potential antitumor agents. 2. Preparation and properties of 7H-pyridocarbazole dimers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retinoid targets for apoptosis induction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BAX-dependent transport of cytochrome c reconstituted in pure liposomes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The inactivation of succinate dehydrogenase by bromopyruvate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Channel formation by antiapoptotic protein Bcl-2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
2-Methoxy antimycin reveals a unique mechanism for Bcl-x(L) inhibition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of cytochrome c release by proapoptotic BCL-2 family members
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-activity studies on gossypol in tumor cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanical aspects of apoptosome assembly
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A unique glucose-dependent apoptotic pathway induced by c-Myc
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anti-apoptotic Bcl-2 Family Proteins Disassemble Ceramide Channels
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A controlled clinical trial of dichloroacetate for treatment of lactic acidosis in adults. The Dichloroacetate-Lactic Acidosis Study Group
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A preliminary clinical study of gossypol in advanced human cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metformin suppresses intestinal polyp growth in ApcMin/+ mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Involvement of the bcl-2 gene in human follicular lymphoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pharmacological studies of a new oral hypoglycemic drug.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeting of VX2 rabbit liver tumor by selective delivery of 3-bromopyruvate: a biodistribution and survival study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Growth factors can influence cell growth and survival through effects on glucose metabolism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Understanding the Warburg effect: the metabolic requirements of cell proliferation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 and metabolism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A stapled BID BH3 helix directly binds and activates BAX
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BID: a novel BH3 domain-only death agonist
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Development of dimeric modulators for anti-apoptotic Bcl-2 proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
On the Origin of Cancer Cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dominant effector genetics in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PUMA induces the rapid apoptosis of colorectal cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Bcl-2 family proteins are essential for platelet survival.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of Bcl-x(L) in beta-cells prevents cell death but impairs mitochondrial signal for insulin secretion
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FEM.20552
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/EM.20552
1 reference
stated in
Europe PubMed Central
PubMed ID
20213841
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213841%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 January 2020
PubMed ID
20213841
1 reference
stated in
Europe PubMed Central
PubMed ID
20213841
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20213841%20AND%20SRC:MED&resulttype=core&format=json
retrieved
19 January 2020
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