(Q26769738)

RNA-based therapeutics: current progress and future prospects.

PubMed

volume

7

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issue

3

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page(s)

316-29

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cites work

1 reference

Potentiality of small interfering RNAs (siRNA) as recent therapeutic targets for gene-silencing.

21 January 2018

1 reference

On the road to reading the RNA-interference code

21 January 2018

1 reference

Exploring chemical modifications for siRNA therapeutics: a structural and functional outlook

21 January 2018

1 reference

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans

21 January 2018

1 reference

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

1 reference

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

21 January 2018

1 reference

Argonaute2 is the catalytic engine of mammalian RNAi

21 January 2018

1 reference

A species of small antisense RNA in posttranscriptional gene silencing in plants

21 January 2018

1 reference

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

1 reference

Structural diversity repertoire of gene silencing small interfering RNAs.

21 January 2018

1 reference

Bioinformatics of siRNA design

21 January 2018

1 reference

The impact of target site accessibility on the design of effective siRNAs

21 January 2018

1 reference

Molecular basis for target RNA recognition and cleavage by human RISC.

21 January 2018

1 reference

Designing chemically modified oligonucleotides for targeted gene silencing

21 January 2018

1 reference

Oligonucleotide delivery: a patent review (2010 - 2013).

21 January 2018

1 reference

Argonaute proteins: functional insights and emerging roles

21 January 2018

1 reference

Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2

21 January 2018

1 reference

Structural insights into RNA processing by the human RISC-loading complex

21 January 2018

1 reference

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

21 January 2018

1 reference

The N domain of Argonaute drives duplex unwinding during RISC assembly

21 January 2018

1 reference

A three-dimensional view of the molecular machinery of RNA interference

21 January 2018

1 reference

Illuminating the silence: understanding the structure and function of small RNAs

21 January 2018

1 reference

Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties

21 January 2018

1 reference

Structural basis for microRNA targeting

21 January 2018

1 reference

Binding and cleavage specificities of human Argonaute2.

21 January 2018

1 reference

The 5' terminal uracil of let-7a is critical for the recruitment of mRNA to Argonaute2.

21 January 2018

1 reference

Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute protein

21 January 2018

1 reference

Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets.

21 January 2018

1 reference

Short interfering RNA guide strand modifiers from computational screening.

21 January 2018

1 reference

Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes

21 January 2018

1 reference

Composition of seed sequence is a major determinant of microRNA targeting patterns

21 January 2018

1 reference

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

21 January 2018

1 reference

Optimal choice of functional and off-target effect-reduced siRNAs for RNAi therapeutics

21 January 2018

1 reference

Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect.

21 January 2018

1 reference

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

21 January 2018

1 reference

Weak base pairing in both seed and 3' regions reduces RNAi off-targets and enhances si/shRNA designs

21 January 2018

1 reference

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

21 January 2018

1 reference

Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

21 January 2018

1 reference

Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.

21 January 2018

1 reference

The Crystal Structure of Human Argonaute2

21 January 2018

1 reference

A-to-I editing in the miRNA seed region regulates target mRNA selection and silencing efficiency

21 January 2018

1 reference

Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA.

21 January 2018

1 reference

Argonaute-dependent small RNAs derived from single-stranded, non-structured precursors

21 January 2018

1 reference

Cleavage of the siRNA passenger strand during RISC assembly in human cells

21 January 2018

1 reference

Slicing-independent RISC activation requires the argonaute PAZ domain

21 January 2018

1 reference

Interactions between the non-seed region of siRNA and RNA-binding RLC/RISC proteins, Ago and TRBP, in mammalian cells

21 January 2018

1 reference

Single modification at position 14 of siRNA strand abolishes its gene-silencing activity by decreasing both RISC loading and target degradation.

21 January 2018

1 reference

Positional effect of chemical modifications on short interference RNA activity in mammalian cells

21 January 2018

1 reference

Modulation of the RNA Interference Activity Using Central Mismatched siRNAs and Acyclic Threoninol Nucleic Acids (aTNA) Units.

21 January 2018

1 reference

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

21 January 2018

1 reference

Minimal mechanistic model of siRNA-dependent target RNA slicing by recombinant human Argonaute 2 protein

21 January 2018

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Single-molecule FRET supports the two-state model of Argonaute action.

21 January 2018

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RNA/aTNA chimeras: RNAi effects and nucleases resistance of single and double stranded RNAs

21 January 2018

1 reference

Effect of north bicyclo[3.1.0]hexane 2'-deoxy-pseudosugars on RNA interference: a novel class of siRNA modification.

21 January 2018

1 reference

RNA interference in mammalia cells by RNA-3'-PNA chimeras

21 January 2018

1 reference

Enhancement of stability and activity of siRNA by terminal substitution with serinol nucleic acid (SNA).

21 January 2018

1 reference

Functionalization of the 3'-ends of DNA and RNA strands with N-ethyl-N-coupled nucleosides: a promising approach to avoid 3'-exonuclease-catalyzed hydrolysis of therapeutic oligonucleotides.

21 January 2018

1 reference

Tuning RNA Interference by Enhancing siRNA/PAZ Recognition

21 January 2018

1 reference

Modified siRNAs for the study of the PAZ domain.

21 January 2018

1 reference

In silico molecular docking analysis of the human Argonaute 2 PAZ domain reveals insights into RNA interference.

21 January 2018

1 reference

Deep Sequencing Analyses of DsiRNAs Reveal the Influence of 3' Terminal Overhangs on Dicing Polarity, Strand Selectivity, and RNA Editing of siRNAs

21 January 2018

1 reference

Structure-based design of novel chemical modification of the 3'-overhang for optimization of short interfering RNA performance.

21 January 2018

1 reference

Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection

21 January 2018

1 reference

siRNA-like double-stranded RNAs are specifically protected against degradation in human cell extract

21 January 2018

1 reference

Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

21 January 2018

1 reference

Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing

21 January 2018

1 reference

Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering

21 January 2018

1 reference

Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants

21 January 2018

1 reference

Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference

21 January 2018

1 reference

Improved silencing properties using small internally segmented interfering RNAs

21 January 2018

1 reference

Asymmetric shorter-duplex siRNA structures trigger efficient gene silencing with reduced nonspecific effects

21 January 2018

1 reference

Asymmetric RNA duplexes mediate RNA interference in mammalian cells.

21 January 2018

1 reference

Asymmetric siRNA: new strategy to improve specificity and reduce off-target gene expression

21 January 2018

1 reference

Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5'-terminal phosphorylation both in vitro and in vivo.

21 January 2018

1 reference

Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity

21 January 2018

1 reference

5' Unlocked Nucleic Acid Modification Improves siRNA Targeting

21 January 2018

1 reference

21 January 2018

Dual-targeting siRNAs

1 reference

Designing dual-targeting siRNA duplexes having two active strands that combine siRNA and microRNA-like targeting.

21 January 2018

1 reference

Experimental validation of the importance of seed complement frequency to siRNA specificity

21 January 2018

1 reference

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

21 January 2018

1 reference

Rational design of immunostimulatory siRNAs.

21 January 2018

1 reference

Modifications in small interfering RNA that separate immunostimulation from RNA interference

21 January 2018

1 reference

Modeling RNA interference in mammalian cells

21 January 2018

1 reference

Both strands of siRNA have potential to guide posttranscriptional gene silencing in mammalian cells

21 January 2018

1 reference

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

21 January 2018

1 reference

The roles of TLRs, RLRs and NLRs in pathogen recognition

21 January 2018

1 reference

siRNA and innate immunity

21 January 2018

1 reference

Interferon-inducible antiviral effectors

21 January 2018

1 reference

The response of mammalian cells to double-stranded RNA

21 January 2018

1 reference

Nucleotide Sequences and Modifications That Determine RIG-I/RNA Binding and Signaling Activities

21 January 2018

1 reference

Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA.

21 January 2018

1 reference

Base modification strategies to modulate immune stimulation by an siRNA.

21 January 2018

1 reference

5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

21 January 2018

1 reference

5' Triphosphorylated small interfering RNAs control replication of hepatitis B virus and induce an interferon response in human liver cells and mice

21 January 2018

1 reference

Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBx-siRNAs in a retinoic acid inducible gene I-dependent manner

21 January 2018

1 reference

Inhibition of hepatitis C virus infection in cell culture by small interfering RNAs

21 January 2018

1 reference

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

21 January 2018

1 reference

siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo.

21 January 2018

1 reference

Multifunctional antitumor molecule 5'-triphosphate siRNA combining glutaminase silencing and RIG-I activation

21 January 2018

1 reference

Therapeutic efficacy of bifunctional siRNA combining TGF-β1 silencing with RIG-I activation in pancreatic cancer

21 January 2018

1 reference

Breaking tumor-induced immunosuppression with 5'-triphosphate siRNA silencing TGFβ and activating RIG-I.

21 January 2018

1 reference

Identifying siRNA-induced off-targets by microarray analysis

21 January 2018

1 reference

Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing.

21 January 2018

1 reference

Self-assembled RNA interference microsponges for efficient siRNA delivery

21 January 2018

1 reference

Exosomes as nucleic acid nanocarriers

21 January 2018

1 reference

Direct cytosolic siRNA delivery by reconstituted high density lipoprotein for target-specific therapy of tumor angiogenesis

21 January 2018

1 reference

Harnessing a physiologic mechanism for siRNA delivery with mimetic lipoprotein particles

21 January 2018

1 reference

Knocking down barriers: advances in siRNA delivery

21 January 2018

1 reference

Drug delivery systems: An updated review

21 January 2018

1 reference

Shielding of Lipid Nanoparticles for siRNA Delivery: Impact on Physicochemical Properties, Cytokine Induction, and Efficacy

21 January 2018

1 reference

Nanovector delivery of siRNA for cancer therapy

21 January 2018

1 reference

Advances in targeted delivery of small interfering RNA using simple bioconjugates

21 January 2018

1 reference

Endosomal escape: a bottleneck in intracellular delivery

21 January 2018

1 reference

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

21 January 2018

1 reference

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

21 January 2018

1 reference

Single-stranded siRNAs activate RNAi in animals

21 January 2018

1 reference

7 January 2021

Introduction to gene silencing and delivery

1 reference

7 January 2021

Medicinal Chemistry of siRNA Delivery

1 reference

7 January 2021

In vivo activity and duration of short interfering RNAs containing a synthetic 5'-phosphate

1 reference

7 January 2021

Adenosine modification may be preferred for reducing siRNA immune stimulation

1 reference

7 January 2021

Gene silencing with siRNA duplexes composed of target-mRNA-complementary and partially palindromic or partially complementary single-stranded siRNAs

1 reference

7 January 2021