(Q37993742)

26 August 2017

Pathways involved in Drosophila and human cancer development: the Notch, Hedgehog, Wingless, Runt, and Trithorax pathway (English)

1 reference

26 August 2017

0 references

Klaus Geissler

1

1 reference

PubMed ID

22418742

26 August 2017

Otto Zach

series ordinal

2

1 reference

26 August 2017

16 March 2012

1 reference

26 August 2017

1 reference

26 August 2017

91

1 reference

26 August 2017

5

1 reference

26 August 2017

645-669

1 reference

Phenotypic changes in dentition of Runx2 homozygote-null mutant mice

26 August 2017

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Characterization of two new zebrafish members of the hedgehog family: atypical expression of a zebrafish indian hedgehog gene in skeletal elements of both endochondral and dermal origins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Interaction between Wingless and Notch signaling pathways mediated by dishevelled.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Modeling the initiation and progression of human acute leukemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Medulloblastoma growth inhibition by hedgehog pathway blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Haematopoietic stem cells derive directly from aortic endothelium during development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Targeted knockdown of Notch1 inhibits invasion of human prostate cancer cells concomitant with inhibition of matrix metalloproteinase-9 and urokinase plasminogen activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Sertoli cell signaling by Desert hedgehog regulates the male germline

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Flavopiridol inhibits P-TEFb and blocks HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Wnt/beta-catenin signaling in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Frequent loss of SFRP1 expression in multiple human solid tumours: association with aberrant promoter methylation in renal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Essential role of stromally induced hedgehog signaling in B-cell malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The SET-domain protein superfamily: protein lysine methyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Homeotic genes and the homeobox

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Darwin and evolutionary tales in leukemia. The Ham-Wasserman Lecture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Hindgut defects and transformation of the gastro-intestinal tract in Tcf4(-/-)/Tcf1(-/-) embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Smoothened as a new therapeutic target for human osteosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Lower levels of nuclear beta-catenin predict for a poorer prognosis in localized prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Cadherin and catenin biology represent a global mechanism for epithelial cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Signalling downstream of activated mammalian Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Notch signalling and the synchronization of the somite segmentation clock

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

DNA methylation and histone modifications cause silencing of Wnt antagonist gene in human renal cell carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Hedgehog signaling protein expression and its association with prognostic parameters in prostate cancer: a retrospective study from the view point of new 2010 anatomic stage/prognostic groups.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Identification of FAP locus genes from chromosome 5q21

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Blood stem cells emerge from aortic endothelium by a novel type of cell transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The canonical Notch signaling pathway: unfolding the activation mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

MLL translocations, histone modifications and leukaemia stem-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

A >or=1 log rise in RQ-PCR transcript levels defines molecular relapse in core binding factor acute myeloid leukemia and predicts subsequent morphologic relapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Prognostic value of real-time quantitative PCR (RQ-PCR) in AML with t(8;21).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

A gene complex controlling segmentation in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Causal relationship between the loss of RUNX3 expression and gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Sonic hedgehog is essential to foregut development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Requirement for Wnt3 in vertebrate axis formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Prognostic significance of the wnt signalling pathway molecules APC, beta-catenin and E-cadherin in colorectal cancer: a tissue microarray-based analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Dimerization of MLL fusion proteins immortalizes hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Developmental roles and clinical significance of hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

New insights to the MLL recombinome of acute leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

COMPASS: a complex of proteins associated with a trithorax-related SET domain protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

MLL targets SET domain methyltransferase activity to Hox gene promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

21 January 2018

The Theory of the Gene

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

ApcMin, a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Growth inhibition of imatinib-resistant CML cells with the T315I mutation and hypoxia-adaptation by AV65--a novel Wnt/β-catenin signaling inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Mutations affecting segment number and polarity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Evolution is condemned to rely upon variations of the same theme: the one ancestral sequence for genes and spacers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

hDOT1L links histone methylation to leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Basal cell carcinomas in mice overexpressing sonic hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Hematopoietic development in the zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Applying the principles of stem-cell biology to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Wnt7b regulates placental development in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Core binding factor acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Controlling the elongation phase of transcription with P-TEFb

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

A role for Wnt signalling in self-renewal of haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Sonic hedgehog mediates the polarizing activity of the ZPA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Cell autonomy of lin-12 function in a cell fate decision in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Effect of the Wingless (wg1) mutation on wing and haltere development in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Sonic Hedgehog promotes multiple drug resistance by regulation of drug transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The molecular biology of mixed lineage leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The super elongation complex (SEC) and MLL in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

The patched/hedgehog/smoothened signalling pathway in human breast cancer: no evidence for H133Y SHH, PTCH and SMO mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Mechanisms of Wnt signaling in development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Therapeutic antibody targeting of individual Notch receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Activating Smoothened mutations in sporadic basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Delta-like 4/Notch signaling and its therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

A paracrine requirement for hedgehog signalling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Altered Hox expression and segmental identity in Mll-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

High Notch1 protein expression is an early event in breast cancer development and is associated with the HER-2 molecular subtype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-012-1435-0

10.1007/S00277-012-1435-0

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22418742