(Q38090682)

28 August 2017

Discovery of ABT-263, a Bcl-family protein inhibitor: observations on targeting a large protein-protein interaction (English)

1 reference

protein-protein interaction

28 August 2017

1 reference

Michael D Wendt

1

1 reference

PubMed ID

23506184

28 August 2017

language of work or name

English

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publication date

1 September 2008

1 reference

Expert Opinion on Drug Discovery

28 August 2017

1 reference

28 August 2017

3

1 reference

28 August 2017

9

1 reference

28 August 2017

1123-1143

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Cell death: critical control points

28 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Apoptosis in the pathogenesis and treatment of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

21 January 2018

Mechanisms of apoptosis

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Apoptosis: molecular mechanisms and implications for cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Bcl-2 family proteins: regulators of chemoresistance in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

The Bcl2 family: regulators of the cellular life-or-death switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

How the Bcl-2 family of proteins interact to regulate apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

The BCL-2 protein family: opposing activities that mediate cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Bax and Bak independently promote cytochrome C release from mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

BH3 domains: intracellular death-ligands critical for initiating apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Drugs targeting protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Solution structure of the antiapoptotic protein bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Discovering high-affinity ligands for proteins: SAR by NMR

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Development of a high-throughput fluorescence polarization assay for Bcl-x(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

A hot spot of binding energy in a hormone-receptor interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Rational design of diflunisal analogues with reduced affinity for human serum albumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Ligand binding to domain-3 of human serum albumin: a chemometric analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

A small-molecule inhibitor of Bcl-XL potentiates the activity of cytotoxic drugs in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Structural biology of the Bcl-2 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Conformational changes associated with protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Fragment-based drug design: how big is too big?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Ligand efficiency indices as guideposts for drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

p21Waf1/Cip1 acts in synergy with bcl-2 to confer multidrug resistance in a camptothecin-selected human lung-cancer cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Discovery of small molecule leads in a biotechnology datastream

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

The design of drug candidate molecules as selective inhibitors of therapeutically relevant protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Synthetic inhibitors of proline-rich ligand-mediated protein-protein interaction: potent analogs of UCS15A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Improving SH3 domain ligand selectivity using a non-natural scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Polar molecular surface properties predict the intestinal absorption of drugs in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Prediction of intestinal permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

21 January 2018

A bioavailability score.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

The SLC22 drug transporter family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

Transient Pockets on Protein Surfaces Involved in Protein−Protein Interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.9.1123

10.1517/17460441.3.9.1123

21 January 2018

Identifiers

DOI

1 reference

28 August 2017

1 reference

PubMed ID

23506184