(Q38112074)

29 August 2017

title

Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme (English)

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29 August 2017

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Bryant England

1

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29 August 2017

Tiangui Huang

series ordinal

2

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29 August 2017

Michael Karsy

series ordinal

3

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29 August 2017

language of work or name

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5 June 2013

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29 August 2017

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29 August 2017

volume

34

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29 August 2017

issue

4

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29 August 2017

page(s)

2063-2074

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Genetic profile of astrocytic and oligodendroglial gliomas

29 August 2017

cites work

1 reference

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p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

21 January 2018

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Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model

21 January 2018

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TP53: a key gene in human cancer.

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p53 suppresses the self-renewal of adult neural stem cells.

21 January 2018

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Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors.

21 January 2018

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p53 regulates the self-renewal and differentiation of neural precursors

21 January 2018

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Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils

21 January 2018

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Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

21 January 2018

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21 January 2018

Surfing the p53 network

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Rescuing the function of mutant p53.

21 January 2018

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Blinded by the Light: The Growing Complexity of p53

21 January 2018

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

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Transcriptional control of human p53-regulated genes

21 January 2018

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Cytoplasmic functions of the tumour suppressor p53.

21 January 2018

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Ubiquitination and degradation of mutant p53.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

The guardian's little helper: microRNAs in the p53 tumor suppressor network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Current Progress on Understanding MicroRNAs in Glioblastoma Multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

microRNA-34a is tumor suppressive in brain tumors and glioma stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

The p53 pathway: positive and negative feedback loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Transcription regulation by mutant p53.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Structural biology of the p53 tumour suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Structural biology of the tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

The isoforms of the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Molecular control of brain size: regulators of neural stem cell life, death and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Frequency variations in the methylated pattern of p73/p21 genes and chromosomal aberrations correlating with different grades of glioma among south Indian population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Mutant p53: an oncogenic transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

The origins and evolution of the p53 family of genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

High affinity MAR-DNA binding is a common property of murine and human mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Specific interaction of mutant p53 with regions of matrix attachment region DNA elements (MARs) with a high potential for base-unpairing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Modulation of gene expression in U251 glioblastoma cells by binding of mutant p53 R273H to intronic and intergenic sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Identification of genomic DNA sequences bound by mutant p53 protein (Gly245-->Ser) in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Mutant p53 proteins bind DNA in a DNA structure-selective mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

p53 and Sp1 Interact and Cooperate in the Tumor Necrosis Factor-induced Transcriptional Activation of the HIV-1 Long Terminal Repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Oncogenomic Approaches in Exploring Gain of Function of Mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Transcriptional activation of the human epidermal growth factor receptor promoter by human p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

'Gain of function' phenotype of tumor-derived mutant p53 requires the oligomerization/nonsequence-specific nucleic acid-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Modulation of gene expression by tumor-derived p53 mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Mutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type II

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Stem cells: The promises and perils of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

The Ink4/Arf locus is a barrier for iPS cell reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

p53 Regulates LIF expression in human medulloblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Tumor spectrum analysis in p53-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

p53 increases experimental metastatic capacity of murine carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Cancer stem cells and "stemness" genes in neuro-oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

The R246S hot-spot p53 mutant exerts dominant-negative effects in embryonic stem cells in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

p53 mutation heterogeneity in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Astrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of polyoma virus middle T antigen in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Neuronal or glial progeny: regional differences in radial glia fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Neural stem cells in mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

The multistep nature of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Gene expression profiling and genetic markers in glioblastoma survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Prognostic impact of molecular markers in a series of 220 primary glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Long-term survival with glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Prognostic significance of molecular markers and extent of resection in primary glioblastoma patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

IDH mutations in glioma and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Impact of p53 status to response of temozolomide in low MGMT expression glioblastomas: preliminary results

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Shaping genetic alterations in human cancer: the p53 mutation paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

The p53 mutation "gradient effect" and its clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Effect of aberrant p53 function on temozolomide sensitivity of glioma cell lines and brain tumor initiating cells from glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

High metastatic potential in mice inheriting a targeted p53 missense mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Characterization of p53 oligomerization domain mutations isolated from Li-Fraumeni and Li-Fraumeni like family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Characterization of the oligomerization defects of two p53 mutants found in families with Li-Fraumeni and Li-Fraumeni-like syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

p53 isoforms can regulate p53 transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Regulatory approvals of pediatric oncology drugs: previous experience and new initiatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

A comparative study of neural and mesenchymal stem cell-based carriers for oncolytic adenovirus in a model of malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Mutant p53 targeting by the low molecular weight compound STIMA-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-013-0871-3

Dominant-negative mutations of the tumor suppressor p53 relating to early onset of glioblastoma multiforme

21 January 2018

1 reference

12 December 2020

What is the clinical value of cancer stem cell markers in gliomas?

1 reference

12 December 2020

p53 and human cancer: the first ten thousand mutations.

1 reference

12 December 2020

Mutant p53 gain of function: reduction of tumor malignancy of human cancer cell lines through abrogation of mutant p53 expression

1 reference

12 December 2020

Ink4a-Arf loss cooperates with KRas activation in astrocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt.

1 reference

12 December 2020

Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results

1 reference

12 December 2020

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1 reference

12 December 2020

p53-R273H gains new function in induction of drug resistance through down-regulation of procaspase-3

1 reference

12 December 2020

p53, p63 and p73--solos, alliances and feuds among family members

1 reference

12 December 2020

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

1 reference

12 December 2020

All-trans retinoic acid modulates cancer stem cells of glioblastoma multiforme in an MAPK-dependent manner

1 reference

12 December 2020

Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation.

1 reference

12 December 2020

Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer

1 reference

12 December 2020

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

1 reference

12 December 2020

DeltaNp63alpha and TAp63alpha regulate transcription of genes with distinct biological functions in cancer and development

1 reference

12 December 2020

Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice

1 reference

12 December 2020

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

12 December 2020

Pharmacological rescue of mutant p53 conformation and function

1 reference

12 December 2020

Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features.

1 reference

12 December 2020

10.1007/S13277-013-0871-3

Identifiers

DOI

1 reference

Dimensions Publication ID

29 August 2017

1052877697

0 references

1 reference