(Q38176051)

30 August 2017

The role of drug metabolizing enzymes in clearance (English)

1 reference

30 August 2017

Li Di

1

1 reference

PubMed ID

24392841

30 August 2017

language of work or name

English

0 references

publication date

7 January 2014

1 reference

Expert Opinion on Drug Metabolism & Toxicology

30 August 2017

1 reference

30 August 2017

10

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30 August 2017

3

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30 August 2017

379-393

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Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19

30 August 2017

1 reference

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Predicting in vivo drug interactions from in vitro drug discovery data

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Prediction of hepatic clearance and availability by cryopreserved human hepatocytes: an application of serum incubation method

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Comparison of the use of liver models for predicting drug clearance using in vitro kinetic data from hepatic microsomes and isolated hepatocytes

21 January 2018

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Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

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Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

21 January 2018

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Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data

21 January 2018

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The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties.

21 January 2018

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Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes

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Hepatocyte composition-based model as a mechanistic tool for predicting the cell suspension: aqueous phase partition coefficient of drugs in in vitro metabolic studies

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Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

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Prediction of hepatic clearance in human from in vitro data for successful drug development

21 January 2018

1 reference

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In vitro-in vivo correlation for low-clearance compounds using hepatocyte relay method.

21 January 2018

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Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites

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Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac

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Mammalian aldehyde oxidases: genetics, evolution and biochemistry.

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Strategies for a comprehensive understanding of metabolism by aldehyde oxidase

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In silico and in vitro pharmacogenetics: aldehyde oxidase rapidly metabolizes a p38 kinase inhibitor

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Case report of extensive metabolism by aldehyde oxidase in humans: pharmacokinetics and metabolite profile of FK3453 in rats, dogs, and humans.

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Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications

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The role of aldehyde oxidase in drug metabolism

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The impact of single nucleotide polymorphisms on human aldehyde oxidase

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Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes.

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Human liver aldehyde oxidase: inhibition by 239 drugs

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Inhibition of human liver aldehyde oxidase: implications for potential drug-drug interactions

21 January 2018

1 reference

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In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase

21 January 2018

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The role of aldehyde oxidase and xanthine oxidase in the biotransformation of a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5.

21 January 2018

1 reference

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Medicinal chemistry approaches to avoid aldehyde oxidase metabolism

21 January 2018

1 reference

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Aldehyde oxidase: an enzyme of emerging importance in drug discovery

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1 reference

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Predicting intrinsic clearance for drugs and drug candidates metabolized by aldehyde oxidase

21 January 2018

1 reference

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Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance

21 January 2018

1 reference

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Interspecies variation in the metabolism of zoniporide by aldehyde oxidase.

21 January 2018

1 reference

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Increasing recognition of the importance of aldehyde oxidase in drug development and discovery

21 January 2018

1 reference

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Evaluation of rhesus monkey and guinea pig hepatic cytosol fractions as models for human aldehyde oxidase

21 January 2018

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Potent inhibition of human liver aldehyde oxidase by raloxifene

21 January 2018

1 reference

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The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification

21 January 2018

1 reference

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UDP-glucuronosyltransferases and clinical drug-drug interactions

21 January 2018

1 reference

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Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches.

21 January 2018

1 reference

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Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

21 January 2018

1 reference

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Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes

21 January 2018

1 reference

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Prediction of biliary excretion in rats and humans using molecular weight and quantitative structure-pharmacokinetic relationships

21 January 2018

1 reference

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Determination of propofol UDP-glucuronosyltransferase (UGT) activities in hepatic microsomes from different species by UFLC-ESI-MS.

21 January 2018

1 reference

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Quantification of human uridine-diphosphate glucuronosyl transferase 1A isoforms in liver, intestine, and kidney using nanobore liquid chromatography-tandem mass spectrometry.

21 January 2018

1 reference

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Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system

21 January 2018

1 reference

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Absolute quantification of human uridine-diphosphate glucuronosyl transferase (UGT) enzyme isoforms 1A1 and 1A6 by tandem LC-MS.

21 January 2018

1 reference

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Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes

21 January 2018

1 reference

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Targeted quantitative proteomics for the analysis of 14 UGT1As and -2Bs in human liver using NanoUPLC-MS/MS with selected reaction monitoring

21 January 2018

1 reference

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The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potentia

21 January 2018

1 reference

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In vitro-in vivo extrapolation predicts drug-drug interactions arising from inhibition of codeine glucuronidation by dextropropoxyphene, fluconazole, ketoconazole, and methadone in humans

21 January 2018

1 reference

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Effect of fluconazole on zidovudine pharmacokinetics in patients infected with human immunodeficiency virus

21 January 2018

1 reference

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Effects of ketamine on human UDP-glucuronosyltransferases in vitro predict potential drug-drug interactions arising from ketamine inhibition of codeine and morphine glucuronidation.

21 January 2018

1 reference

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Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation

21 January 2018

1 reference

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Structural and functional studies of UDP-glucuronosyltransferases

21 January 2018

1 reference

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In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises

21 January 2018

1 reference

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Effect of the beta-glucuronidase inhibitor saccharolactone on glucuronidation by human tissue microsomes and recombinant UDP-glucuronosyltransferases

21 January 2018

1 reference

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Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent

21 January 2018

1 reference

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Characterization of the binding of drugs to human intestinal fatty acid binding protein (IFABP): potential role of IFABP as an alternative to albumin for in vitro-in vivo extrapolation of drug kinetic parameters.

21 January 2018

1 reference

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Characterization of in vitro glucuronidation clearance of a range of drugs in human kidney microsomes: comparison with liver and intestinal glucuronidation and impact of albumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.876006

In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.876006

Relative importance of intestinal and hepatic glucuronidation-impact on the prediction of drug clearance

21 January 2018

1 reference

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Impact of hepatic uptake transporters on pharmacokinetics and drug-drug interactions: use of assays and models for decision making in the pharmaceutical industry

21 January 2018

1 reference

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Application of a physiologically based pharmacokinetic model to assess propofol hepatic and renal glucuronidation in isolation: utility of in vitro and in vivo data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.876006

The effect of incubation conditions on the enzyme kinetics of udp-glucuronosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.876006

S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.876006

Human udp-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid

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1 reference

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Sulfation of o-demethyl apixaban: enzyme identification and species comparison

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1 reference

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Human sulfotransferases and their role in chemical metabolism.

21 January 2018

1 reference

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Inhibition of sulfotransferases by xenobiotics

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1 reference

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Structure, function and polymorphism of human cytosolic sulfotransferases

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1 reference

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Quantitative evaluation of the expression and activity of five major sulfotransferases (SULTs) in human tissues: the SULT "pie".

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Pharmacogenetics of human cytosolic sulfotransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.876006

Downregulation of sulfotransferase expression and activity in diseased human livers

21 January 2018

1 reference

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Bioactivation of benzylic and allylic alcohols via sulfo-conjugation

21 January 2018

1 reference

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Crystal structures of human sulfotransferases: insights into the mechanisms of action and substrate selectivity

21 January 2018

1 reference

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The gate that governs sulfotransferase selectivity

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1 reference

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Study of enzyme kinetics of phenol sulfotransferase by electrophoretically mediated microanalysis

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Solvent effect on cDNA-expressed human sulfotransferase (SULT) activities in vitro

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1 reference

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Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

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Prediction of human drug clearance by multiple metabolic pathways: integration of hepatic and intestinal microsomal and cytosolic data

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Can pharmacogenomics improve malaria drug policy?

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Structural and chemical profiling of the human cytosolic sulfotransferases

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The First Mammalian Aldehyde Oxidase Crystal Structure: INSIGHTS INTO SUBSTRATE SPECIFICITY

21 January 2018

1 reference

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Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.

21 January 2018

1 reference

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Assessment of cryopreserved human hepatocytes as a model system to investigate sulfation and glucuronidation and to evaluate inhibitors of drug conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2014.876006

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

21 January 2018

1 reference

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A Novel Relay Method for Determining Low-Clearance Values

21 January 2018

1 reference

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Activation of Molecular Oxygen by Cytochrome P450

21 January 2018

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Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression

21 January 2018

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Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs

21 January 2018

1 reference

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10.1517/17425255.2014.876006

21 January 2018

Identifiers

DOI

1 reference

30 August 2017

1 reference

PubMed ID

24392841