(Q38182492)

English

Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).

scientific article published on 24 February 2014

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scholarly article

1 reference

Europe PubMed Central

30 August 2017

Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2). (English)

1 reference

Europe PubMed Central

30 August 2017

Heung-Chin Cheng

object named as

Heung-Chin Cheng

5

0 references

Terrence D. Mulhern

object named as

Terrence D Mulhern

2

0 references

object named as

Fei Liu

3

0 references

author name string

Ryan D Mills

1

1 reference

Europe PubMed Central

30 August 2017

Janetta G Culvenor

4

1 reference

Europe PubMed Central

30 August 2017

publication date

24 February 2014

1 reference

Europe PubMed Central

30 August 2017

1 reference

Europe PubMed Central

30 August 2017

35

1 reference

Europe PubMed Central

30 August 2017

4

1 reference

Europe PubMed Central

30 August 2017

395-412

1 reference

Europe PubMed Central

30 August 2017

A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition

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Identification of a carboxyl-terminal diaphanous-related formin homology protein autoregulatory domain

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21 January 2018

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

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21 January 2018

Comparison of ARM and HEAT protein repeats

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

The leucine-rich repeat structure.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation

1 reference

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21 January 2018

GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

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21 January 2018

Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1

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21 January 2018

Roc, a Ras/GTPase domain in complex proteins

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Regulation and function of protein kinases and phosphatases

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21 January 2018

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

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21 January 2018

Structure of the armadillo repeat domain of plakophilin 1

1 reference

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21 January 2018

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

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21 January 2018

A developmental and molecular analysis of Cdc2 mutations in Drosophila melanogaster.

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21 January 2018

Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha

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https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

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https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Foreword: neurodegenerative diseases: challenges and opportunities.

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21 January 2018

On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies

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21 January 2018

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

1 reference

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21 January 2018

The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling

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https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

The crystal structure of polygalacturonase-inhibiting protein (PGIP), a leucine-rich repeat protein involved in plant defense

1 reference

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21 January 2018

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Structural principles of leucine-rich repeat (LRR) proteins

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Structural aspects of Rab6-effector complexes

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan

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https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Expression analysis of Lrrk1, Lrrk2 and Lrrk2 splice variants in mice

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Role of LRRK2 kinase activity in the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

LRRK2 guides the actin cytoskeleton at growth cones together with ARHGEF7 and Tropomyosin 4.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

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https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease

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21 January 2018

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

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https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

A rapid method for determining protein kinase phosphorylation specificity

1 reference

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21 January 2018

Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families

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21 January 2018

Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion

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21 January 2018

Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form

1 reference

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21 January 2018

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Number and brightness analysis of LRRK2 oligomerization in live cells

1 reference

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21 January 2018

Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

The WD40 domain is required for LRRK2 neurotoxicity

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations

1 reference

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21 January 2018

Differential effects of familial parkinson mutations in LRRK2 revealed by a systematic analysis of autophosphorylation.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data

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21 January 2018

Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha

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21 January 2018

Defining the conserved internal architecture of a protein kinase.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

A helix scaffold for the assembly of active protein kinases

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

A putative Ca2+ and calmodulin-dependent protein kinase required for bacterial and fungal symbioses.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Ankyrin repeat: a unique motif mediating protein-protein interactions.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease

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21 January 2018

Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor

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21 January 2018

Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant

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21 January 2018

A Drosophila model for LRRK2-linked parkinsonism

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21 January 2018

Phosphorylation of LRRK2: from kinase to substrate

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21 January 2018

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

The importin β binding domain as a master regulator of nucleocytoplasmic transport

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Expression, purification and preliminary biochemical studies of the N-terminal domain of leucine-rich repeat kinase 2.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Genotypic and phenotypic characteristics of Dutch patients with early onset Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Allostery and binding cooperativity of the catalytic subunit of protein kinase A by NMR spectroscopy and molecular dynamics simulations.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Dynamics connect substrate recognition to catalysis in protein kinase A

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

LRRK2 in Parkinson's disease: protein domains and functional insights

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Crystal structure of a 12 ANK repeat stack from human ankyrinR.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of Sam68

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https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

LRRK2 mutation analysis in Parkinson disease families with evidence of linkage to PARK8.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Interplay of LRRK2 with chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Structural basis of Rho GTPase-mediated activation of the formin mDia1.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Sequences located within the N-terminus of the PD-linked LRRK2 lead to increased aggregation and attenuation of 6-hydroxydopamine-induced cell death

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

RanGAP mediates GTP hydrolysis without an arginine finger

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Deletion of the WD40 domain of LRRK2 in Zebrafish causes Parkinsonism-like loss of neurons and locomotive defect

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

LRRK2 regulates synaptic vesicle endocytosis

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Analysis of LRRK2 functional domains in nondominant Parkinson disease.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Kinase activity of mutant LRRK2 mediates neuronal toxicity

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Structural basis of histone H4 recognition by p55

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Pathogenic mutations in Parkinson disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Crystal structure of a plant ribonuclease, RNase LE

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Molecular basis for recognition of 2',5'-linked oligoadenylates by the N-terminal ankyrin repeat domain of human ribonuclease L.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Understanding and exploiting substrate recognition by protein kinases

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Mechanisms of specificity in protein phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Expression, purification and preliminary biochemical and structural characterization of the leucine rich repeat namesake domain of leucine rich repeat kinase 2.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Multiple Ras functions can contribute to mammalian cell transformation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Structure-function relationships of the G domain, a canonical switch motif

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

GTPase activity plays a key role in the pathobiology of LRRK2.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Through the "gatekeeper door": exploiting the active kinase conformation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Lrrk2 pathogenic substitutions in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

21 January 2018

Effector recognition by the small GTP-binding proteins Ras and Ral

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

7 January 2021

based on heuristic

inferred from DOI database lookup

Type and frequency of mutations in the LRRK2 gene in familial and sporadic Parkinson's disease*.

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

7 January 2021

based on heuristic

inferred from DOI database lookup

A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

7 January 2021

based on heuristic

inferred from DOI database lookup

The Parkinson disease gene LRRK2: evolutionary and structural insights

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

7 January 2021

based on heuristic

inferred from DOI database lookup

Independent occurrence of I2020T mutation in the kinase domain of the leucine rich repeat kinase 2 gene in Japanese and German Parkinson's disease families

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

7 January 2021

based on heuristic

inferred from DOI database lookup

Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the biglycan dimer and evidence that dimerization is essential for folding and stability of class I small leucine-rich repeat proteoglycans

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

7 January 2021

based on heuristic

inferred from DOI database lookup

Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22515

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/HUMU.22515

1 reference

Europe PubMed Central

30 August 2017

1 reference

Europe PubMed Central

30 August 2017

ResearchGate publication ID

0 references

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