(Q38360744)

2 September 2017

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title

Topoisomerase-mediated chromosomal break repair: an emerging player in many games (English)

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2 September 2017

Mohamed E Ashour

1

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2 September 2017

Reham Atteya

series ordinal

2

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2 September 2017

Sherif F El-Khamisy

series ordinal

3

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2 September 2017

language of work or name

English

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publication date

19 February 2015

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2 September 2017

Nature Reviews Cancer

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2 September 2017

15

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2 September 2017

3

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2 September 2017

137-151

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https://scigraph.springernature.com/pub.10.1038/nrc3892

2 September 2017

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cites work

The number of superhelical turns in native Virion SV40 DNA and Minicol DNA determined by the band counting method

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Interaction between DNA and an Escherichia coli protein omega.

21 January 2018

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An activity from mammalian cells that untwists superhelical DNA--a possible swivel for DNA replication (polyoma-ethidium bromide-mouse-embryo cells-dye binding assay).

21 January 2018

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Drugging topoisomerases: lessons and challenges

21 January 2018

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All tangled up: how cells direct, manage and exploit topoisomerase function

21 January 2018

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Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases

21 January 2018

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Cellular roles of dna topoisomerases: a molecular perspective

21 January 2018

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Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders

21 January 2018

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Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation

21 January 2018

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DNA topoisomerases: harnessing and constraining energy to govern chromosome topology

21 January 2018

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Repair of topoisomerase I-mediated DNA damage

21 January 2018

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DNA topoisomerase I affects polycomb group protein-mediated epigenetic regulation and plant development by altering nucleosome distribution in Arabidopsis.

21 January 2018

1 reference

Structure-function studies of a plant tyrosyl-DNA phosphodiesterase provide novel insights into DNA repair mechanisms of Arabidopsis thaliana

21 January 2018

1 reference

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes

21 January 2018

1 reference

Neuroprotection and repair of 3'-blocking DNA ends by glaikit (gkt) encoding Drosophila tyrosyl-DNA phosphodiesterase 1 (TDP1).

21 January 2018

1 reference

Topoisomerase I inhibitors: camptothecins and beyond

21 January 2018

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DNA topoisomerases: structure, function, and mechanism

21 January 2018

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Targeting DNA topoisomerase II in cancer chemotherapy

21 January 2018

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DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

21 January 2018

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Catalytic topoisomerase II inhibitors in cancer therapy.

21 January 2018

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Recent advances in the development of catalytic inhibitors of human DNA topoisomerase IIα as novel anticancer agents.

21 January 2018

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Simultaneous amplification of HER-2 (ERBB2) and topoisomerase IIalpha (TOP2A) genes--molecular basis for combination chemotherapy in cancer

21 January 2018

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Base excision repair intermediates as topoisomerase II poisons

21 January 2018

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Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons

21 January 2018

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TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks

21 January 2018

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TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

21 January 2018

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Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells

21 January 2018

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Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

21 January 2018

1 reference

Transcription poisoning by Topoisomerase I is controlled by gene length, splice sites, and miR-142-3p

21 January 2018

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Topoisomerases facilitate transcription of long genes linked to autism

21 January 2018

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Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

21 January 2018

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Activation of ATM and histone H2AX phosphorylation induced by mitoxantrone but not by topotecan is prevented by the antioxidant N-acetyl-L-cysteine.

21 January 2018

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Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase

21 January 2018

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Adriamycin-induced oxidative mitochondrial cardiotoxicity

21 January 2018

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Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

21 January 2018

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Doxorubicin enhances nucleosome turnover around promoters

21 January 2018

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Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin

21 January 2018

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ATM is required for the repair of Topotecan-induced replication-associated double-strand breaks

21 January 2018

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DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair

21 January 2018

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Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK

21 January 2018

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TDP1 serine 81 promotes interaction with DNA ligase IIIalpha and facilitates cell survival following DNA damage

21 January 2018

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Phosphorylation of PNKP by ATM prevents its proteasomal degradation and enhances resistance to oxidative stress

21 January 2018

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ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair

21 January 2018

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ATM: expanding roles as a chief guardian of genome stability

21 January 2018

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ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells

21 January 2018

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Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

21 January 2018

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The dispersal of replication proteins after Etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway

21 January 2018

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Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.

21 January 2018

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Activation of DNA damage response pathways as a consequence of anthracycline-DNA adduct formation

21 January 2018

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Differential and common DNA repair pathways for topoisomerase I- and II-targeted drugs in a genetic DT40 repair cell screen panel

21 January 2018

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A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

21 January 2018

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Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

21 January 2018

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AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe

21 January 2018

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TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

21 January 2018

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Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage

21 January 2018

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TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.

21 January 2018

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TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo

21 January 2018

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SUMO modification of the neuroprotective protein TDP1 facilitates chromosomal single-strand break repair.

21 January 2018

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PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage

21 January 2018

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TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan

21 January 2018

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DNA repair and resistance to topoisomerase I inhibitors: mechanisms, biomarkers and therapeutic targets.

21 January 2018

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Topoisomerase I inhibition in colorectal cancer: biomarkers and therapeutic targets.

21 January 2018

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Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

21 January 2018

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The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1

21 January 2018

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Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) inhibitors

21 January 2018

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5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.

21 January 2018

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Identification of novel PARP inhibitors using a cell-based TDP1 inhibitory assay in a quantitative high-throughput screening platform

21 January 2018

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A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

21 January 2018

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Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses

21 January 2018

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An RNA virus hijacks an incognito function of a DNA repair enzyme

21 January 2018

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Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2⋅DNA and Top2⋅RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

21 January 2018

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TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage

21 January 2018

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Mutant p53 cooperates with ETS2 to promote etoposide resistance

21 January 2018

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Oncogenic role of EAPII in lung cancer development and its activation of the MAPK-ERK pathway.

21 January 2018

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Structural basis for recognition of 5′-phosphotyrosine adducts by Tdp2

21 January 2018

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Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).

21 January 2018

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Mechanism of repair of 5′-topoisomerase II–DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2

21 January 2018

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Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family

21 January 2018

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Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

21 January 2018

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Cell cycle-and proteasome-dependent formation of etoposide-induced replication protein A (RPA) or Mre11/Rad50/Nbs1 (MRN) complex repair foci

21 January 2018

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Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

21 January 2018

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Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes

21 January 2018

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Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

21 January 2018

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Structure-specific endonucleases xpf and mus81 play overlapping but essential roles in DNA repair by homologous recombination.

21 January 2018

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Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4.

21 January 2018

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Human CtIP promotes DNA end resection

21 January 2018

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Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions

21 January 2018

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Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair

21 January 2018

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The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression

21 January 2018

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Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection

21 January 2018

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Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes

21 January 2018

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CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1.

21 January 2018

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Topoisomerase I poisoning results in PARP-mediated replication fork reversal

21 January 2018

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Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

21 January 2018

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Transcription generates positively and negatively supercoiled domains in the template.

21 January 2018

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R loops: from transcription byproducts to threats to genome stability

21 January 2018

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Out of balance: R-loops in human disease

21 January 2018

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Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation.

21 January 2018

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A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

21 January 2018

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A breaking strategy for topoisomerase IIbeta/PARP-1-dependent regulated transcription

21 January 2018

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Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

21 January 2018

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Role of topoisomerase IIbeta in the expression of developmentally regulated genes.

21 January 2018

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Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae

21 January 2018

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Role for topoisomerase 1 in transcription-associated mutagenesis in yeast

21 January 2018

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Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.

21 January 2018

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Site-specific ribonuclease activity of eukaryotic DNA topoisomerase I.

21 January 2018

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Two distinct mechanisms of Topoisomerase 1-dependent mutagenesis in yeast

21 January 2018

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Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I

21 January 2018

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Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms

21 January 2018

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21 January 2018

Global cancer statistics

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Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

21 January 2018

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Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

21 January 2018

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Recurrent gene fusions in prostate cancer

21 January 2018

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Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer

21 January 2018

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Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in prostate cancer

21 January 2018

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Androgen-induced TMPRSS2:ERG fusion in nonmalignant prostate epithelial cells.

21 January 2018

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Functional activation of ATM by the prostate cancer suppressor NKX3.1.

21 January 2018

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Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells

21 January 2018

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TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function

21 January 2018

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Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.

21 January 2018

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Genistein induces topoisomerase IIbeta- and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia

21 January 2018

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Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents.

21 January 2018

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The pathogenesis of mixed-lineage leukemia

21 January 2018

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The ENCODE project: missteps overshadowing a success

21 January 2018

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Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity

21 January 2018

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DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis

21 January 2018

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Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspot

21 January 2018

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Zinc Finger Nuclease induced DNA double stranded breaks and rearrangements in MLL.

21 January 2018

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A model for all genomes: the role of transcription factories

21 January 2018

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Nuclear organization and genome function

21 January 2018

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Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity

21 January 2018

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Topoisomerase II and the etiology of chromosomal translocations

21 January 2018

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PARP1 is required for chromosomal translocations.

21 January 2018

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DNA topoisomerase II in therapy-related acute promyelocytic leukemia.

21 January 2018

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Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia

21 January 2018

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Clinicobiological features and outcome of acute promyelocytic leukemia occurring as a second tumor: the GIMEMA experience

21 January 2018

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21 January 2018

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Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis

21 January 2018

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Analysis of t(15;17) chromosomal breakpoint sequences in therapy-related versus de novo acute promyelocytic leukemia: association of DNA breaks with specific DNA motifs at PML and RARA loci

21 January 2018

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Molecular pathogenesis of secondary acute promyelocytic leukemia

21 January 2018

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The ABCs of infant leukemia.

21 January 2018

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Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons

21 January 2018

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Bioflavonoids as poisons of human topoisomerase II alpha and II beta

21 January 2018

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Cells lacking DNA topoisomerase II beta are resistant to genistein

21 January 2018

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Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group.

21 January 2018

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Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor hypothesis: a report from the children's oncology group

21 January 2018

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Dietary flavonoids induce MLL translocations in primary human CD34+ cells

21 January 2018

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Dietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemia

21 January 2018

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Prenatal exposure to flavonoids: implication for cancer risk

21 January 2018

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Transcription-induced DNA double strand breaks: both oncogenic force and potential therapeutic target?

21 January 2018

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Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks

21 January 2018

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BAF complexes facilitate decatenation of DNA by topoisomerase IIα

21 January 2018

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Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

21 January 2018

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TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo

21 January 2018

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Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide

21 January 2018

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Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

21 January 2018

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Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

21 January 2018

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Transcription linked to recombination: a gene-internal promoter coincides with the recombination hot spot II of the human MLL gene

21 January 2018

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Antitumour drugs impede DNA uncoiling by topoisomerase I

21 January 2018

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Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan

21 January 2018

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Interfacial inhibitors: targeting macromolecular complexes

31 March 2020

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Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects

31 March 2020

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ATM specifically mediates repair of double-strand breaks with blocked DNA ends

31 March 2020

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Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II

31 March 2020

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A DNA-dependent protease involved in DNA-protein crosslink repair

31 March 2020

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Stimulated activity of human topoisomerases IIalpha and IIbeta on RNA-containing substrates

31 March 2020

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Induced chromosomal proximity and gene fusions in prostate cancer

31 March 2020

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Minimal DNA duplex requirements for topoisomerase I-mediated cleavage in vitro

31 March 2020

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12 December 2020

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I

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12 December 2020

Infant acute leukemias show the same biased distribution of ALL1 gene breaks as topoisomerase II related secondary acute leukemias.

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12 December 2020

Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA.

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12 December 2020

Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors

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12 December 2020

Transcription linked to recombination: a gene-internal promoter coincides with the recombination hot spot II of the human MLL gene

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12 December 2020

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin

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12 December 2020

Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites

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12 December 2020

An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region

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12 December 2020

Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system

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12 December 2020

DNA damage induced by DNA topoisomerase I- and topoisomerase II-inhibitors detected by histone H2AX phosphorylation in relation to the cell cycle phase and apoptosis

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12 December 2020

Identifiers

DOI

10.1038/NRC3892

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Dimensions Publication ID

2 September 2017

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