(Q38416739)

2 September 2017

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title

Tailoring recombinant protein quality by rational media design (English)

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2 September 2017

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4

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2 September 2017

David Brühlmann

1

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2 September 2017

Martin Jordan

2

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2 September 2017

Jürgen Hemberger

3

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2 September 2017

Matthieu Stettler

5

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2 September 2017

Hervé Broly

6

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2 September 2017

publication date

29 April 2015

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2 September 2017

published in

Biotechnology Progress

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2 September 2017

volume

31

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2 September 2017

issue

3

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2 September 2017

page(s)

615-629

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Mammalian cell protein expression for biopharmaceutical production

2 September 2017

cites work

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Towards dynamic metabolic flux analysis in CHO cell cultures

21 January 2018

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Production of recombinant protein therapeutics in cultivated mammalian cells

21 January 2018

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Cell culture processes for monoclonal antibody production

21 January 2018

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Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process

21 January 2018

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Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

21 January 2018

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21 January 2018

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Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics

21 January 2018

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Post-translational modifications of recombinant proteins: significance for biopharmaceuticals

21 January 2018

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Strategies for analysing and improving the expression and quality of recombinant proteins made in mammalian cells

21 January 2018

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Effects of charge on antibody tissue distribution and pharmacokinetics.

21 January 2018

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C-terminal modification of monoclonal antibody drugs: amidated species as a general product-related substance

21 January 2018

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Non-fucosylated therapeutic antibodies as next-generation therapeutic antibodies

21 January 2018

1 reference

Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats

21 January 2018

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Recent advances in technology supporting biopharmaceutical production from mammalian cells

21 January 2018

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Protein aggregation and bioprocessing

21 January 2018

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Free light chain content in culture media reflects recombinant monoclonal antibody productivity and quality

21 January 2018

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Marketing approval of mogamulizumab: a triumph for glyco-engineering

21 January 2018

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Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation

21 January 2018

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Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures

21 January 2018

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Hyperosmotic stress and elevated pCO2 alter monoclonal antibody charge distribution and monosaccharide content

21 January 2018

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Conversion of a CHO cell culture process from perfusion to fed-batch technology without altering product quality.

21 January 2018

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Optimal and consistent protein glycosylation in mammalian cell culture

21 January 2018

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Product quality considerations for mammalian cell culture process development and manufacturing

21 January 2018

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Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

21 January 2018

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Probing of C-terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media

21 January 2018

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Modulation of mAb quality attributes using microliter scale fed-batch cultures.

21 January 2018

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Cell culture medium improvement by rigorous shuffling of components using media blending

21 January 2018

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A high-throughput media design approach for high performance mammalian fed-batch cultures

21 January 2018

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Amino acid and manganese supplementation modulates the glycosylation state of erythropoietin in a CHO culture system.

21 January 2018

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Depletion of manganese within the secretory pathway inhibits O-linked glycosylation in mammalian cells

21 January 2018

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Protein glycosylation in diverse cell systems: implications for modification and analysis of recombinant proteins

21 January 2018

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On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database

21 January 2018

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Heterogeneity of monoclonal antibodies

21 January 2018

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Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures.

21 January 2018

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Effects of cell culture conditions on antibody N-linked glycosylation--what affects high mannose 5 glycoform

21 January 2018

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Effect of hydrocortisone on the production and glycosylation of an Fc-fusion protein in CHO cell cultures

21 January 2018

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Fucose content of monoclonal antibodies can be controlled by culture medium osmolality for high antibody-dependent cellular cytotoxicity

21 January 2018

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Investigation of the correlation between charge and glycosylation of IgG1 variants by liquid chromatography-mass spectrometry

21 January 2018

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Glycosylation as a strategy to improve antibody-based therapeutics

21 January 2018

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Quality attributes of recombinant therapeutic proteins: an assessment of impact on safety and efficacy as part of a quality by design development approach

21 January 2018

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Towards the implementation of quality by design to the production of therapeutic monoclonal antibodies with desired glycosylation patterns

21 January 2018

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The impact of glycosylation on the biological function and structure of human immunoglobulins.

21 January 2018

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Controlling glycation of recombinant antibody in fed-batch cell cultures

21 January 2018

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Importance of measuring products of non-enzymatic glycation of proteins

21 January 2018

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Effects of zinc and manganese on advanced glycation end products (AGEs) formation and AGEs-mediated endothelial cell dysfunction.

21 January 2018

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A study in glycation of a therapeutic recombinant humanized monoclonal antibody: where it is, how it got there, and how it affects charge-based behavior

21 January 2018

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The effect of glycation on the structure, function and biological fate of human serum albumin as revealed by recombinant mutants

21 January 2018

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High-end pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO fed-batch cultures.

21 January 2018

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Basal medium development for serum-free culture: a historical perspective

21 January 2018

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Metabolic effects on recombinant interferon-gamma glycosylation in continuous culture of Chinese hamster ovary cells

21 January 2018

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The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody.

21 January 2018

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Effect of glucose feeding on the glycosylation quality of antibody produced by a human cell line, F2N78, in fed-batch culture

21 January 2018

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Metabolic shifts do not influence the glycosylation patterns of a recombinant fusion protein expressed in BHK cells.

21 January 2018

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Glucose-limited chemostat culture of Chinese hamster ovary cells producing recombinant human interferon-gamma

21 January 2018

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An investigation of intracellular glycosylation activities in CHO cells: effects of nucleotide sugar precursor feeding

21 January 2018

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Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana

21 January 2018

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Novel mannosidase inhibitors probe glycoprotein degradation pathways in cells

21 January 2018

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Development of a simple and rapid method for producing non-fucosylated oligomannose containing antibodies with increased effector function

21 January 2018

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Recent advances in the understanding of biological implications and modulation methodologies of monoclonal antibody N-linked high mannose glycans

21 January 2018

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Biological properties of D- and L-1-deoxyazasugars

21 January 2018

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Mechanistic insights into a Ca2+-dependent family of α-mannosidases in a human gut symbiont

21 January 2018

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Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate

21 January 2018

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The Molecular Basis of Inhibition of Golgi α-Mannosidase II by Mannostatin A

21 January 2018

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Molecular mechanism of the glycosylation step catalyzed by Golgi alpha-mannosidase II: a QM/MM metadynamics investigation.

21 January 2018

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Identification of manipulated variables for a glycosylation control strategy

21 January 2018

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Cell culture media supplementation of uncommonly used sugars sucrose and tagatose for the targeted shifting of protein glycosylation profiles of recombinant protein therapeutics

21 January 2018

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Development of fucosyltransferase and fucosidase inhibitors

21 January 2018

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Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

21 January 2018

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Triazine dyes as inhibitors and affinity ligands of glycosyltransferases.

21 January 2018

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An efficient approach to the discovery of potent inhibitors against glycosyltransferases.

21 January 2018

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Inhibition of fucosyltransferase VII by gallic acid and its derivatives

21 January 2018

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Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells

21 January 2018

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Glycosyltransferase activity can be modulated by small conformational changes of acceptor substrates.

21 January 2018

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Inhibition of hybrid- and complex-type glycosylation reveals the presence of the GlcNAc transferase I-independent fucosylation pathway

21 January 2018

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CHO cell line specific prediction and control of recombinant monoclonal antibody N-glycosylation

21 January 2018

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Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells

21 January 2018

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Control of galactosylated glycoforms distribution in cell culture system.

21 January 2018

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Specificity of β1,4-galactosyltransferase inhibition by 2-naphthyl 2-butanamido-2-deoxy-1-thio-β-D-glucopyranoside

21 January 2018

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Effects of elevated ammonium on glycosylation gene expression in CHO cells

21 January 2018

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The first C-glycosidic analogue of a novel galactosyltransferase inhibitor.

21 January 2018

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Deoxygenated Disaccharide Analogs as Specific Inhibitors of 1-4-Galactosyltransferase 1 and Selectin-mediated Tumor Metastasis

21 January 2018

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Selective inhibition of glycosyltransferases by bivalent imidazolium salts

21 January 2018

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Metabolic control of recombinant protein N-glycan processing in NS0 and CHO cells

21 January 2018

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Enhanced sialylation of EPO by overexpression of UDP-GlcNAc 2-epimerase/ManAc kinase containing a sialuria mutation in CHO cells.

21 January 2018

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Increasing the sialylation of therapeutic glycoproteins: the potential of the sialic acid biosynthetic pathway

21 January 2018

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Characterization of the cellular uptake and metabolic conversion of acetylated N-acetylmannosamine (ManNAc) analogues to sialic acids

21 January 2018

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Enhanced production of monomeric interferon-beta by CHO cells through the control of culture conditions.

21 January 2018

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Effects of ammonia and glucosamine on the heterogeneity of erythropoietin glycoforms.

21 January 2018

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Human sialidase inhibitors: design, synthesis, and biological evaluation of 4-acetamido-5-acylamido-2-fluoro benzoic acids

21 January 2018

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Effect of lithium chloride on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture.

21 January 2018

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Betanin reduces the accumulation and cross-links of collagen in high-fructose-fed rat heart through inhibiting non-enzymatic glycation

21 January 2018

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Inhibition of advanced glycation endproduct formation by foodstuffs

21 January 2018

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Method to differentiate asn deamidation that occurred prior to and during sample preparation of a monoclonal antibody

21 January 2018

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Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods

21 January 2018

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Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptides

21 January 2018

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Asparagine deamidation dependence on buffer type, pH, and temperature

21 January 2018

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Controlling deamidation rates in a model peptide: effects of temperature, peptide concentration, and additives

21 January 2018

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Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization.

21 January 2018

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Methionine, tryptophan, and histidine oxidation in a model protein, PTH: mechanisms and stabilization

21 January 2018

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Chemical instability of protein pharmaceuticals: Mechanisms of oxidation and strategies for stabilization

21 January 2018

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C-terminal lysine variants in fully human monoclonal antibodies: investigation of test methods and possible causes

21 January 2018

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Method to convert N-terminal glutamine to pyroglutamate for characterization of recombinant monoclonal antibodies

21 January 2018

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Acceptable changes in quality attributes of glycosylated biopharmaceuticals

21 January 2018

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Cation exchange-HPLC and mass spectrometry reveal C-terminal amidation of an IgG1 heavy chain.

21 January 2018

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Characterization of the basic charge variants of a human IgG1: effect of copper concentration in cell culture media

21 January 2018

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Effect of cell culture medium components on color of formulated monoclonal antibody drug substance.

21 January 2018

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Arginine modifications by methylglyoxal: discovery in a recombinant monoclonal antibody and contribution to acidic species

21 January 2018

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Aggregates in monoclonal antibody manufacturing processes

21 January 2018

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Direct analysis of mAb aggregates in mammalian cell culture supernatant.

21 January 2018

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Protein aggregation during overexpression limited by peptide extensions with large net negative charge.

21 January 2018

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Use of NaCl prevents aggregation of recombinant COMP-angiopoietin-1 in Chinese hamster ovary cells.

21 January 2018

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Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein

21 January 2018

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Comparative Evaluation of Disodium Edetate and Diethylenetriaminepentaacetic Acid as Iron Chelators to Prevent Metal -Catalyzed Destabilization of a Therapeutic Monoclonal Antibody

21 January 2018

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Protein aggregation: pathways, induction factors and analysis

21 January 2018

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Improvement of mammalian cell culture performance through surfactant enabled concentrated feed media

21 January 2018

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Trehalose suppresses antibody aggregation during the culture of Chinese hamster ovary cells.

21 January 2018

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Glycosylation analysis of an aggregated antibody produced by Chinese hamster ovary cells in bioreactor culture

21 January 2018

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Fragmentation of monoclonal antibodies

21 January 2018

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Mapping and partial characterization of proteases expressed by a CHO production cell line

21 January 2018

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Degradation of an Fc-fusion recombinant protein by host cell proteases: Identification of a CHO cathepsin D protease.

21 January 2018

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Fragmentation of a highly purified monoclonal antibody attributed to residual CHO cell protease activity

21 January 2018

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Elevated cleavage of human immunoglobulin gamma molecules containing a lambda light chain mediated by iron and histidine

21 January 2018

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Effect of copper sulfate on performance of a serum-free CHO cell culture process and the level of free thiol in the recombinant antibody expressed

21 January 2018

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Mechanism of antibody reduction in cell culture production processes.

21 January 2018

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Targeting proteases: successes, failures and future prospects

21 January 2018

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Discovery and investigation of misincorporation of serine at asparagine positions in recombinant proteins expressed in Chinese hamster ovary cells

21 January 2018

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Control of misincorporation of serine for asparagine during antibody production using CHO cells

21 January 2018

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Rational development of a serum-free medium and fed-batch process for a GS-CHO cell line expressing recombinant antibody

21 January 2018

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Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus

21 January 2018

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23 October 2023

https://opencitations.net/index/coci/api/v1/citations/10.1016/J.METABOL.2009.04.035

Mannostatins A and B: new inhibitors of alpha-D-mannosidase, produced by Streptoverticillium verticillus var. quintum ME3-AG3: taxonomy, production, isolation, physico-chemical properties and biological activities.

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.42.883

Identifiers

DOI

10.1002/BTPR.2089

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2 September 2017

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