(Q38518851)

3 September 2017

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title

Context-dependent actions of Polycomb repressors in cancer (English)

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3 September 2017

M Koppens

1

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3 September 2017

M van Lohuizen

series ordinal

2

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3 September 2017

language of work or name

English

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publication date

8 June 2015

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3 September 2017

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3 September 2017

volume

35

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3 September 2017

issue

11

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3 September 2017

page(s)

1341-1352

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Role of histone H3 lysine 27 methylation in Polycomb-group silencing

3 September 2017

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Noncoding RNA and Polycomb recruitment.

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Regulatory Roles for Long ncRNA and mRNA

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Non-coding RNAs as direct and indirect modulators of epigenetic regulation

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Identification and Validation of a Putative Polycomb Responsive Element in the Human Genome

21 January 2018

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A region of the human HOXD cluster that confers polycomb-group responsiveness

21 January 2018

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A vertebrate Polycomb response element governs segmentation of the posterior hindbrain

21 January 2018

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A novel human polycomb binding site acts as a functional polycomb response element in Drosophila

21 January 2018

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Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains

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An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

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GC-rich sequence elements recruit PRC2 in mammalian ES cells

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Hyperconserved CpG domains underlie Polycomb-binding sites

21 January 2018

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PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes

21 January 2018

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Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation

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Ras-induced changes in H3K27me3 occur after those in transcriptional activity

21 January 2018

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Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.195

Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.195

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.195

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.195

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.195

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.195

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.195

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.195

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2015.195

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Oncogenic Y641 mutations in EZH2 prevent Jak2/β-TrCP-mediated degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Clinical effect of point mutations in myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

EZH2 mutational status predicts poor survival in myelofibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Polycomb repressive complex 2 is required for MLL-AF9 leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

IDH mutation impairs histone demethylation and results in a block to cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

BMI1 sustains human glioblastoma multiforme stem cell renewal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Eaten alive: a history of macroautophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Self-renewal as a therapeutic target in human colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Id1 enhances RING1b E3 ubiquitin ligase activity through the Mel-18/Bmi-1 polycomb group complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Analysis of Mel-18 expression in prostate cancer tissues and correlation with clinicopathologic features

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

The novel tumor-suppressor Mel-18 in prostate cancer: its functional polymorphism, expression and clinical significance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Expression and clinicopathological significance of Mel-18 mRNA in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

BMI1 and Mel-18 oppositely regulate carcinogenesis and progression of gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Expression and clinicopathological significance of Mel-18 and Bmi-1 mRNA in gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Mel-18 negatively regulates INK4a/ARF-independent cell cycle progression via Akt inactivation in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Low expression of Mel-18 predicts poor prognosis in patients with breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Loss of the polycomb protein Mel-18 enhances the epithelial-mesenchymal transition by ZEB1 and ZEB2 expression through the downregulation of miR-205 in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Loss of Mel-18 enhances breast cancer stem cell activity and tumorigenicity through activating Notch signaling mediated by the Wnt/TCF pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Recognition and Specificity Determinants of the Human Cbx Chromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Polycomb CBX7 has a unifying role in cellular lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Role of the chromobox protein CBX7 in lymphomagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Microarray analysis of pediatric ependymoma identifies a cluster of 112 candidate genes including four transcripts at 22q12.1-q13.3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Loss of the CBX7 gene expression correlates with a highly malignant phenotype in thyroid cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Identification of a New Pathway for Tumor Progression: MicroRNA-181b Up-Regulation and CBX7 Down-Regulation by HMGA1 Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Altered expression of polycomb group genes in glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

CBX7 is a tumor suppressor in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

CBX7 modulates the expression of genes critical for cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Cbx2, a polycomb group gene, is required for Sry gene expression in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Male-to-female sex reversal in M33 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Disruption of E2F signaling suppresses the INK4a-induced proliferative defect in M33-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Clinical relevance of breast cancer-related genes as potential biomarkers for oral squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Additive effect of the AZGP1, PIP, S100A8 and UBE2C molecular biomarkers improves outcome prediction in breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Chromobox homolog 4 is correlated with prognosis and tumor cell growth in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

The polycomb protein Pc2 is a SUMO E3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

MLL-ENL inhibits polycomb repressive complex 1 to achieve efficient transformation of hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

CBX8 suppresses Sirtinol-induced premature senescence in human breast cancer cells via cooperation with SIRT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

21 January 2018

Mapping cancer origins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Circulating Bmi-1 mRNA as a possible prognostic factor for advanced breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Dysregulated expression of stem cell factor Bmi1 in precancerous lesions of the gastrointestinal tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Expression level of Bmi-1 oncoprotein is associated with progression and prognosis in colon cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Expression of the polycomb-group gene BMI1 is related to an unfavourable prognosis in primary nodal DLBCL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Expression of B-cell-specific Moloney murine leukemia virus integration site 1 mRNA and protein in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Bmi1 enhances tumorigenicity and cancer stem cell function in pancreatic adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

H2AK119Ub1 and H3K27Me3 in molecular staging for survival prediction of patients with pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

RYBP expression is associated with better survival of patients with hepatocellular carcinoma (HCC) and responsiveness to chemotherapy of HCC cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Diffuse large B-cell lymphoma with histone H3 trimethylation at lysine 27: another poor prognostic phenotype independent of c-Myc/Bcl2 coexpression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Mutations and prognosis in primary myelofibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Prognostic value of polycomb proteins EZH2, BMI1 and SUZ12 and histone modification H3K27me3 in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

EZH2 and STAT6 expression profiles are correlated with colorectal cancer stage and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

EZH2 protein expression associates with the early pathogenesis, tumor progression, and prognosis of non-small cell lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Quantitative analysis of EZH2 expression and its correlations with lung cancer patients' clinical pathological characteristics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

EZH2 protein: a promising immunomarker for the detection of hepatocellular carcinomas in liver needle biopsies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Prognostic value of EZH2 expression and activity in renal cell carcinoma: a prospective study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

The polycomb group protein EZH2 is involved in progression of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Clinical significance of Polycomb gene expression in brain tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

The number of prognostically detrimental mutations and prognosis in primary myelofibrosis: an international study of 797 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

The relationship between Bmi-1 and the epithelial-mesenchymal transition in lung squamous cell carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Polycomb complexes regulate cellular senescence by repression of ARF in cooperation with E2F3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Bmi-1 expression predicts prognosis for patients with gastric carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Expression of Polycomb-group (PcG) protein BMI-1 predicts prognosis in patients with acute myeloid leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Polycomb-group oncogenes EZH2, BMI1, and RING1 are overexpressed in prostate cancer with adverse pathologic and clinical features

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.195

A role for mel-18, a Polycomb group-related vertebrate gene, during theanteroposterior specification of the axial skeleton

31 March 2020

1 reference

12 December 2020

Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression

1 reference

12 December 2020

Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice.

1 reference

12 December 2020

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

1 reference

12 December 2020

Molecular profiles of pre- and postoperative breast cancer tumours reveal differentially expressed genes

1 reference

12 December 2020

Stage-specific expression of polycomb group genes in human bone marrow cells

1 reference

12 December 2020

mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity

1 reference

12 December 2020

Correlations of BMI-1 expression and telomerase activity in ovarian cancer tissues

1 reference

12 December 2020

Microarray analysis of pediatric ependymoma identifies a cluster of 112 candidate genes including four transcripts at 22q12.1-q13.3

1 reference

12 December 2020

Identifiers

DOI

10.1038/ONC.2015.195

1 reference

Dimensions Publication ID

3 September 2017

1020805157

0 references

1 reference