(Q38608688)

4 September 2017

Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism (English)

1 reference

4 September 2017

1 reference

1 reference

Menattallah Elserafy

6

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Mohamed M Ali

object named as

Mohamed M Ali

4

0 references

Arwa A Abugable

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author name string

Arwa A Abugable

1

1 reference

4 September 2017

Dahlia A Awwad

2

1 reference

4 September 2017

Dalia Fleifel

3

1 reference

4 September 2017

Sherif El-Khamisy

5

1 reference

4 September 2017

language of work or name

English

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publication date

1 January 2017

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Advances in Experimental Medicine and Biology

4 September 2017

1 reference

4 September 2017

1007

1 reference

4 September 2017

157-178

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https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

4 September 2017

1 reference

Scope and limitations of yeast as a model organism for studying human tissue-specific pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Manipulating yeast genome using plasmid vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Manipulating the yeast genome: deletion, mutation, and tagging by PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Non-homologous end-joining factors of Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

DSB repair: the yeast paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Nucleotide excision repair in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Replication-Associated Recombinational Repair: Lessons from Budding Yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Topoisomerase-mediated chromosomal break repair: an emerging player in many games

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

DNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Surviving chromosome replication: the many roles of the S-phase checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Cyclin dependent kinases and cell cycle control (nobel lecture).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Universal control mechanism regulating onset of M-phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Checking on DNA damage in S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Visualization of altered replication dynamics after DNA damage in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A unified view of the DNA-damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

An essential gene, ESR1, is required for mitotic cell growth, DNA repair and meiotic recombination in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Identification of yeast mutants with altered telomere structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The recognition of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Cell cycle checkpoints: preventing an identity crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The DNA replication checkpoint response stabilizes stalled replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Radiosensitivity in ataxia-telangiectasia: a new explanation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

ATM: genome stability, neuronal development, and cancer cross paths

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

SMRT compounds abrogate cellular phenotypes of ataxia telangiectasia in neural derivatives of patient-specific hiPSCs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Exploring Splicing-Switching Molecules For Seckel Syndrome Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Detection of CHK1 and CCND1 gene copy number changes in breast cancer with dual-colour fluorescence in-situ hybridization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

RNAi screening of the kinome identifies modulators of cisplatin response in ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Cross-species genomic and functional analyses identify a combination therapy using a CHK1 inhibitor and a ribonucleotide reductase inhibitor to treat triple-negative breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Roles of Chk1 in cell biology and cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Replication stress and cancer: it takes two to tango.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Unleashing Chk1 in cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Checkpoint kinase 1 inhibitors for potentiating systemic anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Somatic mutations affect key pathways in lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The combined status of ATM and p53 link tumor development with therapeutic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Expression pattern of ATM and cyclin D1 in ductal carcinoma, normal adjacent and normal breast tissues of Iranian breast cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

ATM gene deletion in patients with adult acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Genetic abnormalities and clinical outcome in chronic lymphocytic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Epigenetic inactivation of checkpoint kinase 2 gene in non-small cell lung cancer and its relationship with clinicopathological features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

CHK2 kinase expression is down-regulated due to promoter methylation in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Single-agent inhibition of Chk1 is antiproliferative in human cancer cell lines in vitro and inhibits tumor xenograft growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU60019.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Targeting radiation-resistant hypoxic tumour cells through ATR inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide].

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Targeted radiosensitization by the Chk1 inhibitor SAR-020106.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

γH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Trial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

ATR inhibition preferentially targets homologous recombination-deficient tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The depletion of ATM inhibits colon cancer proliferation and migration via B56γ2-mediated Chk1/p53/CD44 cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Autoregulatory mechanisms of phosphorylation of checkpoint kinase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Phase I dose-escalation trial of checkpoint kinase 1 inhibitor MK-8776 as monotherapy and in combination with gemcitabine in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Phase I studies of CBP501, a G2 checkpoint abrogator, as monotherapy and in combination with cisplatin in patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Evaluation of the likelihood of a selective CHK1 inhibitor (LY2603618) to inhibit CYP2D6 with desipramine as a probe substrate in cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Meiotic versus mitotic recombination: two different routes for double-strand break repair: the different functions of meiotic versus mitotic DSB repair are reflected in different pathway usage and different outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Purified human BRCA2 stimulates RAD51-mediated recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Rad52 inactivation is synthetically lethal with BRCA2 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Homologous recombination and its regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Mechanism of eukaryotic homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Rad54, the motor of homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Effects of the rad52 gene on sister chromatid recombination in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Complex formation in yeast double-strand break repair: participation of Rad51, Rad52, Rad55, and Rad57 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Direct association between the yeast Rad51 and Rad54 recombination proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Isolation and characterization of the human MRE11 homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The multiple roles of the Mre11 complex for meiotic recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Synergistic actions of Rad51 and Rad52 in recombination and DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Germline mutations in RAD51D confer susceptibility to ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

RAD51 haploinsufficiency causes congenital mirror movements in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

RAD51 as a potential biomarker and therapeutic target for pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Rad51 overexpression contributes to chemoresistance in human soft tissue sarcoma cells: a role for p53/activator protein 2 transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeutic agents in mouse xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

HDAC Inhibition Induces MicroRNA-182, which Targets RAD51 and Impairs HR Repair to Sensitize Cells to Sapacitabine in Acute Myelogenous Leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Down-regulation of Rad51 expression overcomes drug resistance to gemcitabine in human non-small-cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Genetic variation in a hsa-let-7 binding site in RAD52 is associated with breast cancer susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

PRKDC mutations in a SCID patient with profound neurological abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The response to and repair of RAG-mediated DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Mechanism of DNA double-strand break repair by non-homologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The mechanism of non-homologous end-joining: a synopsis of synapsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Saccharomyces cerevisiae cell cycle mutant cdc9 is defective in DNA ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

DNA ligase IV from HeLa cell nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Stop pulling my strings - what telomeres taught us about the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

DNA ligase IV syndrome; a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

DNA end joining activity is reduced in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

DNA-PKcs: A promising therapeutic target in human hepatocellular carcinoma?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

DNA-PK-A candidate driver of hepatocarcinogenesis and tissue biomarker that predicts response to treatment and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Radiation-hypersensitive cancer patients do not manifest protein expression abnormalities in components of the nonhomologous end-joining (NHEJ) pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Identification and validation of human DNA ligase inhibitors using computer-aided drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Interaction between DNA and an Escherichia coli protein omega.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

An activity from mammalian cells that untwists superhelical DNA--a possible swivel for DNA replication (polyoma-ethidium bromide-mouse-embryo cells-dye binding assay).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Drugging topoisomerases: lessons and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Cellular roles of dna topoisomerases: a molecular perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Repair of topoisomerase I-mediated DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

DNA topoisomerases and their poisoning by anticancer and antibacterial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Yeast gene for a Tyr-DNA phosphodiesterase that repairs topoisomerase I complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2⋅DNA and Top2⋅RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

ATM deficiency results in accumulation of DNA-topoisomerase I covalent intermediates in neural cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A DNA-dependent protease involved in DNA-protein crosslink repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Collaborative action of Brca1 and CtIP in elimination of covalent modifications from double-strand breaks to facilitate subsequent break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Human CtIP promotes DNA end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Spinocerebellar ataxia with axonal neuropathy: consequence of a Tdp1 recessive neomorphic mutation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

TDP1 facilitates repair of ionizing radiation-induced DNA single-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

C9orf72 expansion disrupts ATM-mediated chromosomal break repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Conversion of phosphoglycolate to phosphate termini on 3' overhangs of DNA double strand breaks by the human tyrosyl-DNA phosphodiesterase hTdp1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

AP endonuclease independent repair of abasic sites in Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Synthesis and biological evaluation of novel tyrosyl-DNA phosphodiesterase 1 inhibitors with a benzopentathiepine moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Structural and functional relationships of the XPF/MUS81 family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Sequence analysis identifies TTRAP, a protein that associates with CD40 and TNF receptor-associated factors, as a member of a superfamily of divalent cation-dependent phosphodiesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Topoisomerases facilitate transcription of long genes linked to autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

DNA topoisomerase II and its growing repertoire of biological functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Mutant p53 cooperates with ETS2 to promote etoposide resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Isoquinoline-1,3-diones as Selective Inhibitors of Tyrosyl DNA Phosphodiesterase II (TDP2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

CRISPR gene-editing tested in a person for the first time.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Recombinant adeno-associated viral vectors in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

In vivo genome editing using Staphylococcus aureus Cas9

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

Functionally homologous cell cycle control genes in budding and fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F978-3-319-60733-7_9

10.1007/978-3-319-60733-7_9

21 January 2018

Identifiers

DOI

1 reference

4 September 2017

1 reference