(Q39489194)

12 September 2017

title

The Nicastrin ectodomain adopts a highly thermostable structure (English)

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12 September 2017

7

Christian Haass

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Regina Fluhrer

1

object named as

Regina Fluhrer

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12 September 2017

Frits Kamp

2

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12 September 2017

Gudula Grammer

3

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12 September 2017

Brigitte Nuscher

4

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12 September 2017

Harald Steiner

5

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12 September 2017

Klaus Beyer

6

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12 September 2017

publication date

1 November 2011

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12 September 2017

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12 September 2017

volume

392

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12 September 2017

issue

11

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12 September 2017

page(s)

995-1001

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The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

12 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Glu-333 of nicastrin directly participates in gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Structural and functional stability of the mature transferrin receptor from human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Effect of glycosylation on protein folding: a close look at thermodynamic stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Gamma-secretase activity is associated with a conformational change of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Intramembrane proteolysis by gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1515%2FBC.2011.169

21 January 2018

Identifiers

DOI

10.1515/BC.2011.169

1 reference

release_36aajikwqjf7fj2aoc2bvu36tm

12 September 2017

Fatcat ID

0 references

1 reference