(Q40684851)

22 September 2017

title

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation (English)

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22 September 2017

4

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22 September 2017

11

Christian Haass

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Gerd Multhaup

2

object named as

Gerd Multhaup

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22 September 2017

1

Regina Fluhrer

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22 September 2017

9

Wolfram Bode

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22 September 2017

Andrea Schlicksupp

3

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22 September 2017

Masatoshi Takeda

5

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22 September 2017

Sven Lammich

6

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22 September 2017

Michael Willem

7

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22 September 2017

Gil Westmeyer

8

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22 September 2017

Jochen Walter

10

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22 September 2017

language of work or name

English

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publication date

5 December 2002

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Journal of Biological Chemistry

22 September 2017

published in

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22 September 2017

volume

278

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22 September 2017

issue

8

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22 September 2017

page(s)

5531-5538

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Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

22 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

A non-amyloidogenic function of BACE-2 in the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

BACE2 functions as an alternative alpha-secretase in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Notch signaling: from the outside in

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Presenilin-dependent gamma-secretase activity modulates thymocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Apical sorting of beta-secretase limits amyloid beta-peptide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

The functional gamma-secretase inhibitor prevents production of amyloid beta 1-34 in human and murine cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Processing of beta-secretase by furin and other members of the proprotein convertase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Metabolic regulation of brain Abeta by neprilysin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Generation of amyloid beta protein from its precursor is sequence specific

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Insulin-degrading enzyme: embarking on amyloid destruction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Gamma -secretase inhibitors repress thymocyte development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Convertases other than furin cleave beta-secretase to its mature form.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211485200

21 January 2018

Identifiers

DOI

10.1074/JBC.M211485200

1 reference

22 September 2017

1 reference