(Q41045804)

English

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration

scientific article published on 20 June 2016

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scholarly article

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Europe PubMed Central

26 September 2017

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration (English)

1 reference

Europe PubMed Central

26 September 2017

protein ubiquitination

1 reference

based on heuristic

inferred from title

Dolores Del Prete

1

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325702%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Anjali Rajadhyaksha

3

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9 June 2020

Luciano D'Adamio

4

1 reference

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9 June 2020

Luciano D'Adamio

5

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9 June 2020

author name string

Richard C Rice

2

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9 June 2020

language of work or name

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publication date

20 June 2016

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26 September 2017

Journal of Biological Chemistry

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9 June 2020

291

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9 June 2020

33

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9 June 2020

17209-17227

1 reference

Europe PubMed Central

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9 June 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5016122/fullTextXML

based on heuristic

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The business of deubiquitination - location, location, location

1 reference

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26 September 2017

Parkinsonism, movement disorders and genetics in frontotemporal dementia

1 reference

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26 September 2017

The Metamorphic Nature of the Tau Protein: Dynamic Flexibility Comes at a Cost

1 reference

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26 September 2017

Mammalian proteasome subtypes: Their diversity in structure and function

1 reference

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26 September 2017

The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior.

1 reference

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26 September 2017

Tau and neurodegenerative disease: the story so far.

1 reference

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26 September 2017

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

1 reference

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26 September 2017

The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications

1 reference

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26 September 2017

From UBE3A to Angelman syndrome: a substrate perspective

1 reference

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26 September 2017

The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism

1 reference

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26 September 2017

Dehydroeffusol effectively inhibits human gastric cancer cell-mediated vasculogenic mimicry with low toxicity

1 reference

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26 September 2017

Homozygous SLC6A17 mutations cause autosomal-recessive intellectual disability with progressive tremor, speech impairment, and behavioral problems

1 reference

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26 September 2017

Thalidomide mimics uridine binding to an aromatic cage in cereblon

1 reference

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26 September 2017

SCF ubiquitin ligase-targeted therapies.

1 reference

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26 September 2017

Mutant SNAP25B causes myasthenia, cortical hyperexcitability, ataxia, and intellectual disability

1 reference

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26 September 2017

STUB1 mutations in autosomal recessive ataxias - evidence for mutation-specific clinical heterogeneity

1 reference

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26 September 2017

APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions

1 reference

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26 September 2017

Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy

1 reference

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26 September 2017

Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs

1 reference

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26 September 2017

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

1 reference

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26 September 2017

Donor splice-site mutation in CUL4B is likely cause of X-linked intellectual disability

1 reference

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26 September 2017

Mutations in USP9X are associated with X-linked intellectual disability and disrupt neuronal cell migration and growth

1 reference

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26 September 2017

Recent progress in the genetics of motor neuron disease

1 reference

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26 September 2017

Ubiquitin ligase defect by DCAF8 mutation causes HMSN2 with giant axons

1 reference

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26 September 2017

Identification of CHIP as a novel causative gene for autosomal recessive cerebellar ataxia

1 reference

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26 September 2017

Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system

1 reference

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26 September 2017

Mechanisms and function of substrate recruitment by F-box proteins.

1 reference

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26 September 2017

Clinical and neuropathological features of X-linked spinal muscular atrophy (SMAX2) associated with a novel mutation in the UBA1 gene.

1 reference

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26 September 2017

An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss

1 reference

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26 September 2017

The genetics of Alzheimer disease

1 reference

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26 September 2017

Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance

1 reference

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26 September 2017

An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples.

1 reference

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26 September 2017

VAMP1 mutation causes dominant hereditary spastic ataxia in Newfoundland families

1 reference

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26 September 2017

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

1 reference

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26 September 2017

Ubiquilins in the crosstalk among proteolytic pathways

1 reference

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26 September 2017

Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia

1 reference

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26 September 2017

Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease

1 reference

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26 September 2017

Physiological functions of APP family proteins

1 reference

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26 September 2017

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

1 reference

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26 September 2017

The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.

1 reference

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26 September 2017

The role of the ubiquitin proteasome system in Alzheimer's disease

1 reference

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26 September 2017

A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.

1 reference

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26 September 2017

Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo

1 reference

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26 September 2017

Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro

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26 September 2017

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis

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26 September 2017

Identification of a primary target of thalidomide teratogenicity

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26 September 2017

The secretases: enzymes with therapeutic potential in Alzheimer disease

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26 September 2017

Proteomic analysis of protein phosphorylation and ubiquitination in Alzheimer's disease.

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26 September 2017

CRL4s: the CUL4-RING E3 ubiquitin ligases

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26 September 2017

Modeling familial British and Danish dementia

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26 September 2017

Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.

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26 September 2017

The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains

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26 September 2017

BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2

1 reference

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26 September 2017

Phosphorylation of a tyrosine in the amyloid-beta protein precursor intracellular domain inhibits Fe65 binding and signaling.

1 reference

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26 September 2017

BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.

1 reference

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26 September 2017

Regulation of cullin RING ligases

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26 September 2017

Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with mental retardation

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26 September 2017

Ubiquitin-proteasome system dysfunction in Parkinson's disease: current evidence and controversies

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26 September 2017

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

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26 September 2017

The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53.

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26 September 2017

CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism.

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26 September 2017

Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation

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26 September 2017

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26 September 2017

Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor

1 reference

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26 September 2017

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

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26 September 2017

SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain

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26 September 2017

The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production

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26 September 2017

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

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26 September 2017

Commonality of TRIM32 mutation in causing sarcotubular myopathy and LGMD2H.

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26 September 2017

Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2

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26 September 2017

The COP9 signalosome (CSN): an evolutionary conserved proteolysis regulator in eukaryotic development

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26 September 2017

A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation

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26 September 2017

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

1 reference

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26 September 2017

Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.

1 reference

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26 September 2017

The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing.

1 reference

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26 September 2017

Identification of a mutation in synapsin I, a synaptic vesicle protein, in a family with epilepsy

1 reference

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26 September 2017

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

1 reference

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26 September 2017

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

1 reference

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26 September 2017

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

2 references

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26 September 2017

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21 January 2018

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

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26 September 2017

Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein

1 reference

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26 September 2017

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

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26 September 2017

JNK-interacting protein-1 promotes transcription of A beta protein precursor but not A beta precursor-like proteins, mechanistically different than Fe65

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Apolipoprotein E in macrophages and hepatocytes is eegraded via the proteasomal pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Presenilin function in APP processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Expression analysis of BACE2 in brain and peripheral tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

A stop-codon mutation in the BRI gene associated with familial British dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Carboxyl-terminal fragments of beta-amyloid precursor protein bind to microtubules and the associated protein tau

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

26 September 2017

A novel nonsense mutation in CUL4B gene in three brothers with X-linked mental retardation syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

14 June 2018

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

14 June 2018

Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

14 June 2018

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Interactome of the amyloid precursor protein APP in brain reveals a protein network involved in synaptic vesicle turnover and a close association with Synaptotagmin-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

FISH and array-CGH analysis of a complex chromosome 3 aberration suggests that loss of CNTN4 and CRBN contributes to mental retardation in 3pter deletions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Case-control study of the parkin gene in early-onset Parkinson disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Analysis of an early-onset Parkinson's disease cohort for DJ-1 mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK-interacting protein (JIP)-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

A short cytoplasmic domain of the amyloid precursor protein induces apoptosis in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5016122

19 August 2018

Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M116.733626

21 January 2018

The amyloid precursor protein and its network of interacting proteins: physiological and pathological implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/27325702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired proteasome function in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27325702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/27325702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autosomal recessive cerebellar ataxia of adult onset due to STUB1 mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/27325702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ataxia plus myoclonus in a 23-year-old patient due to STUB1 mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/27325702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protective mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27325702

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M116.733626

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325702%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325702%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27325702%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

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