(Q41427586)

English

NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease

scientific article published on 15 February 2015

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scholarly article

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Europe PubMed Central

30 September 2017

NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease (English)

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30 September 2017

Alzheimer's disease

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Antonella Borreca

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Simona D'Aguanno

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Vanessa Nicolin

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Giuseppina Amadoro

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F Florenzano

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A Bobba

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M T Ciotti

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F Natale

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F Della Valle

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A Manca

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C Ferraina

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M Feligioni

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R Bussani

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M Ammassari-Teule

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P Calissano

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V Corsetti

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publication date

15 February 2015

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Human Molecular Genetics

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3058-3081

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11

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3 June 2020

Phosphorylation and cleavage of tau in non-AD tauopathies.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Proteolytic processing of tau.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Synaptic mitochondrial pathology in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

A role for tau at the synapse in Alzheimer's disease pathogenesis.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Role of the ubiquitin proteasome system in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Ubiquitin and the synapse.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Interaction between NH(2)-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Caspase-cleaved tau expression induces mitochondrial dysfunction in immortalized cortical neurons: implications for the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Truncated tau and Aβ cooperatively impair mitochondria in primary neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitochondrial dysfunction - the beginning of the end in Alzheimer's disease? Separate and synergistic modes of tau and amyloid-β toxicity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Neurodegeneration as a consequence of failed mitochondrial maintenance

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Why size matters - balancing mitochondrial dynamics in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Autophagocytosis of mitochondria is prominent in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitochondrial DNA damage as a mechanism of cell loss in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitochondrial alterations near amyloid plaques in an Alzheimer's disease mouse model.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Autophagy of mitochondria: a promising therapeutic target for neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitochondrial homeostasis: the interplay between mitophagy and mitochondrial biogenesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

After the banquet: mitochondrial biogenesis, mitophagy, and cell survival

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Roles of autophagy in MPP+-induced neurotoxicity in vivo: the involvement of mitochondria and α-synuclein aggregation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Role of autophagy in protection afforded by hypoxic preconditioning against MPP+-induced neurotoxicity in SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Dynamic survey of mitochondria by ubiquitin.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

A role for ubiquitin in selective autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink-parkin pathway

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: implications to mitochondria-targeted antioxidant therapeutics

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitochondrial quality control by the ubiquitin-proteasome system

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Long time-lapse imaging reveals unique features of PARK2/Parkin-mediated mitophagy in mature cortical neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Axonal transport of two major components of the ubiquitin system: free ubiquitin and ubiquitin carboxyl-terminal hydrolase PGP 9.5

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Reversal of long-term dendritic spine alterations in Alzheimer disease models

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Aβ1-42-mediated down-regulation of Uch-L1 is dependent on NF-κB activation and impaired BACE1 lysosomal degradation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Profiling of Parkin-binding partners using tandem affinity purification

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Role of N-terminal tau domain integrity on the survival of cerebellar granule neurons.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

NMDA receptor mediates tau-induced neurotoxicity by calpain and ERK/MAPK activation.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Identification of a caspase-derived N-terminal tau fragment in cellular and animal Alzheimer's disease models.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Amyloid beta-mediated cell death of cultured hippocampal neurons reveals extensive Tau fragmentation without increased full-length tau phosphorylation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

The generation of a 17 kDa neurotoxic fragment: an alternative mechanism by which tau mediates beta-amyloid-induced neurodegeneration.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

A NH2 tau fragment targets neuronal mitochondria at AD synapses: possible implications for neurodegeneration.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Impact of N-tau on adult hippocampal neurogenesis, anxiety, and memory.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Parkin interacts with Ambra1 to induce mitophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Assessing neuronal bioenergetic status

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Hexokinase activity is required for recruitment of parkin to depolarized mitochondria

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

The interplay of neuronal mitochondrial dynamics and bioenergetics: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Alterations in the common fragile site gene Parkin in ovarian and other cancers

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https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Autoregulation of Parkin activity through its ubiquitin-like domain

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Age-related mitochondrial alterations without neuronal loss in the hippocampus of a transgenic model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitochondrial bioenergetics is defective in presymptomatic Tg2576 AD mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Synaptosome proteomics

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

1 reference

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21 January 2018

Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitochondrial α-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Parkin depletion delays motor decline dose-dependently without overtly affecting neuropathology in α-synuclein transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Mitochondrial dismissal in mammals, from protein degradation to mitophagy

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

A double-edged sword with therapeutic potential: an updated role of autophagy in ischemic cerebral injury.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Analysis of a membrane-enriched proteome from postmortem human brain tissue in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Genetic association between Ubiquitin Carboxy-terminal Hydrolase-L1 gene S18Y polymorphism and sporadic Alzheimer's disease in a Chinese Han population.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Parkin promotes intracellular Abeta1-42 clearance

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Dopamine covalently modifies and functionally inactivates parkin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Regulation of parkin and PINK1 by neddylation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

The role of estrogens on the proliferation of human breast tumor cells (MCF-7).

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Reactive oxygen species generation is modulated by mitochondrial kinases: correlation with mitochondrial antioxidant peroxidases in rat tissues

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Extracellular protons differentially potentiate the responses of native AMPA receptor subtypes regulating neurotransmitter release

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

alphaCaMKII autophosphorylation levels differ depending on subcellular localization

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV059

21 January 2018

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