(Q53322611)

13 May 2018

title

Metabolic targeting of oncogene MYC by selective activation of the proton-coupled monocarboxylate family of transporters. (English)

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13 May 2018

author name string

L Gan

1

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13 May 2018

R Xiu

2

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13 May 2018

P Ren

3

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13 May 2018

M Yue

4

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13 May 2018

H Su

5

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13 May 2018

G Guo

6

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13 May 2018

D Xiao

7

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13 May 2018

J Yu

8

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13 May 2018

H Jiang

9

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13 May 2018

H Liu

10

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13 May 2018

G Hu

11

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13 May 2018

G Qing

12

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13 May 2018

language of work or name

English

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publication date

5 October 2015

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13 May 2018

published in

Oncogene

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13 May 2018

volume

35

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13 May 2018

issue

23

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13 May 2018

page(s)

3037-3048

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13 May 2018

https://scigraph.springernature.com/pub.10.1038/onc.2015.360

exact match

0 references

cites work

Brick by brick: metabolism and tumor cell growth

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Cell biology. Metabolic control of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Glutamine and cancer: cell biology, physiology, and clinical opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

THE METABOLISM OF TUMORS IN THE BODY

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

MYC on the path to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Transcriptional regulation and transformation by Myc proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

The monocarboxylate transporter family--role and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

The SLC16 gene family - structure, role and regulation in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

ATF4 and N-Myc coordinate glutamine metabolism in MYCN-amplified neuroblastoma cells through ASCT2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Glutamine deprivation enhances antitumor activity of 3-bromopyruvate through the stabilization of monocarboxylate transporter-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Widespread microRNA repression by Myc contributes to tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-Cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-d-glucose in tumor cells treated under hypoxic vs aerobic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Glycolysis inhibition for anticancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Ultrasound-guided direct delivery of 3-bromopyruvate blocks tumor progression in an orthotopic mouse model of human pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Systemic delivery of microencapsulated 3-bromopyruvate for the therapy of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Molecular Pathways: Targeting MYC-induced metabolic reprogramming and oncogenic stress in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Targeting MYCN in neuroblastoma by BET bromodomain inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Targeting metabolic transformation for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Regulation of cancer cell metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

Targeting cancer metabolism: a therapeutic window opens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

The combined status of ATM and p53 link tumor development with therapeutic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

A two-way street: reciprocal regulation of metabolism and signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.360

MYC, metabolism, cell growth, and tumorigenesis.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26434591

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26434591

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2015.360

1 reference

13 May 2018

Dimensions Publication ID

0 references

1 reference

13 May 2018