(Q81527536)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18581273%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

review article

1 reference

title

Therapeutic strategies for Alzheimer's disease (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18581273%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

1 reference

Donna M Barten

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18581273%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Charles F Albright

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18581273%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

publication date

1 April 2008

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18581273%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

published in

Molecular Neurobiology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18581273%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

volume

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18581273%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

issue

2-3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18581273%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

page(s)

171-186

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18581273%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s12035-008-8031-2

9 January 2020

exact match

0 references

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Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

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In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

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Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

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Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

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Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

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12 December 2020

Alzheimer's Disease Pathology in Non-Demented Elderly

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

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A brief history of tau: the evolving view of the microtubule-associated protein tau in neurodegenerative diseases

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12 December 2020

Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease

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12 December 2020

Autophagy in neurodegenerative disease: friend, foe or turncoat?

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12 December 2020

Mitochondria as a target for neurotoxins and neuroprotective agents

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12 December 2020

Neurons may live for decades with neurofibrillary tangles.

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12 December 2020

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

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12 December 2020

Functional outcomes of drug treatment in Alzheimer's disease: A systematic review and meta-analysis

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12 December 2020

Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications

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12 December 2020

A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's Disease

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12 December 2020

The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs.

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12 December 2020

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

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12 December 2020

Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease

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12 December 2020

Vessel ultrastructure in APP23 transgenic mice after passive anti-Abeta immunotherapy and subsequent intracerebral hemorrhage.

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12 December 2020

Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

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12 December 2020

Medicinal chemistry strategies to 5-HT(6) receptor ligands as potential cognitive enhancers and antiobesity agents

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12 December 2020

Alzheimer-like changes in rat models of spontaneous diabetes

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12 December 2020

Endocannabinoids and synaptic function in the CNS.

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12 December 2020

Mitochondrial aging and dysfunction in Alzheimer's disease

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12 December 2020

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

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12 December 2020

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

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12 December 2020

Granular tau oligomers as intermediates of tau filaments

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12 December 2020

The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice

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12 December 2020

Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cells

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12 December 2020

Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.

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12 December 2020

Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression

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12 December 2020

Phosphodiesterase inhibitors for cognitive enhancement

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12 December 2020

Perspective on a pathogenesis and treatment of Alzheimer's disease.

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12 December 2020

On the molecular basis linking Nerve Growth Factor (NGF) to Alzheimer's disease

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12 December 2020

Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice

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12 December 2020

Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial

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12 December 2020

Neurotrophin receptor-based strategies for Alzheimer's disease

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12 December 2020

Molecular mechanism of neuronal plasticity: induction and maintenance of long-term potentiation in the hippocampus

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12 December 2020

Cerebral hemorrhage after passive anti-Abeta immunotherapy.

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12 December 2020

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

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12 December 2020

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

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12 December 2020

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

1 reference

12 December 2020

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

1 reference

12 December 2020

Tau phosphorylation in Alzheimer's disease: pathogen or protector?

1 reference

12 December 2020

A network dysfunction perspective on neurodegenerative diseases

1 reference

12 December 2020

Effects of Abeta immunization (AN1792) on MRI measures of cerebral volume in Alzheimer disease.

1 reference

12 December 2020

Advances in gamma-secretase modulation.

1 reference

12 December 2020

Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro.

1 reference

12 December 2020

Disrupting beta-amyloid aggregation for Alzheimer disease treatment

1 reference

12 December 2020

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

1 reference

12 December 2020

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

12 December 2020

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

1 reference

12 December 2020

GABAB receptor: a site of therapeutic benefit

1 reference

12 December 2020

Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum

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12 December 2020

Iron dysregulation in Alzheimer's disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents

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12 December 2020

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

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12 December 2020

Bace1 modulates myelination in the central and peripheral nervous system.

1 reference

12 December 2020

Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity.

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12 December 2020

Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics

1 reference

12 December 2020

Nicotinic receptor agonists as neuroprotective/neurotrophic drugs. Progress in molecular mechanisms

1 reference

12 December 2020

Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice.

1 reference

12 December 2020

Cholinesterase inhibitors stabilize Alzheimer's disease

1 reference

12 December 2020

Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine

1 reference

12 December 2020

Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice

1 reference

12 December 2020

Microtubule-stabilizing agent prevents protein accumulation-induced loss of synaptic markers

1 reference

12 December 2020

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

1 reference

12 December 2020

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

1 reference

12 December 2020

Pharmacological inhibitors of glycogen synthase kinase 3.

1 reference

12 December 2020

Smoking and Parkinson's and Alzheimer's disease: review of the epidemiological studies

1 reference

12 December 2020

Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice

1 reference

12 December 2020

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

12 December 2020

Looking for novel ways to treat the hallmarks of Alzheimer's disease

1 reference

12 December 2020

The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation.

1 reference

12 December 2020

Deregulated GSK3beta activity in colorectal cancer: its association with tumor cell survival and proliferation.

1 reference

12 December 2020

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

1 reference

12 December 2020

Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond

1 reference

12 December 2020

Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

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12 December 2020

Muscarinic M(1) agonists in the treatment of Alzheimer's disease

1 reference

12 December 2020

Minocycline does not affect amyloid beta phagocytosis by human microglial cells.

1 reference

12 December 2020

Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors

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12 December 2020

Antioxidants and Alzheimer's disease: time to stop feeding vitamin E to dementia patients?

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12 December 2020

Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity

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12 December 2020

A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease.

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12 December 2020

Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.

1 reference

12 December 2020

Alzheimer's disease is a synaptic failure

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12 December 2020

Potential compensatory responses through autophagic/lysosomal pathways in neurodegenerative diseases

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12 December 2020

Muscarinic acetylcholine receptor knockout mice: novel phenotypes and clinical implications

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12 December 2020

The role of tau phosphorylation in the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

1 reference

12 December 2020

Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI)

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12 December 2020

Lithium ions: a novel treatment for pheochromocytomas and paragangliomas

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12 December 2020

Glycogen synthase kinase 3: a drug target for CNS therapies

1 reference

12 December 2020

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

1 reference

12 December 2020

Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study

1 reference

12 December 2020

Neuroprotective therapies for Alzheimer's disease

1 reference

12 December 2020

Gamma-secretase modulation with Abeta42-lowering nonsteroidal anti-inflammatory drugs and derived compounds

1 reference

12 December 2020

LTP inhibits LTD in the hippocampus via regulation of GSK3beta

1 reference

12 December 2020

Disease modifying strategies for the treatment of Alzheimer's disease targeted at modulating levels of the beta-amyloid peptide

1 reference

12 December 2020

Muscarinic agonists and antagonists in the treatment of Alzheimer's disease

1 reference

12 December 2020

The gamma-secretase complex: membrane-embedded proteolytic ensemble

1 reference

12 December 2020

Nerve growth factor gene delivery: animal models to clinical trials

1 reference

12 December 2020

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

1 reference

12 December 2020

Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

1 reference

12 December 2020

S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila.

1 reference

12 December 2020

New Alzheimer's clinical trials to be undertaken by NIA nationwide consortium

1 reference

12 December 2020

Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration

1 reference

12 December 2020

Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice.

1 reference

12 December 2020

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

1 reference

12 December 2020

Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics

1 reference

12 December 2020

Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

1 reference

12 December 2020

Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases.

1 reference

12 December 2020

Drug evaluation: (R)-flurbiprofen--an enantiomer of flurbiprofen for the treatment of Alzheimer's disease

1 reference

12 December 2020

Combination of rimonabant and donepezil prolongs spatial memory duration

1 reference

12 December 2020

Distinct presenilin‐dependent and presenilin‐independent γ‐secretases are responsible for total cellular Aβ production

1 reference

12 December 2020

Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer

1 reference

12 December 2020

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

1 reference

12 December 2020

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

1 reference

12 December 2020

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

1 reference

12 December 2020

Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria

1 reference

12 December 2020

Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms

1 reference

12 December 2020

Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic-pharmacodynamic discordance

1 reference

12 December 2020

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

1 reference

12 December 2020

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

1 reference

12 December 2020

Recent advances in the development of hybrid molecules/designed multiple compounds with antiamnesic properties

1 reference

12 December 2020

Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease

1 reference

12 December 2020

Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.

1 reference

12 December 2020

Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies

1 reference

12 December 2020

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins

1 reference

12 December 2020

Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments.

1 reference

12 December 2020

Forecasting the global burden of Alzheimer’s disease

1 reference

12 December 2020

Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease.

1 reference

12 December 2020

Two sides of the same coin: Wnt signaling in neurodegeneration and neuro-oncology.

1 reference

12 December 2020

Disease-modifying therapies for Alzheimer disease: challenges to early intervention

1 reference

12 December 2020

Statin therapy in Alzheimer's disease

1 reference

12 December 2020

Control of peripheral nerve myelination by the beta-secretase BACE1

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

1 reference

12 December 2020

Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

1 reference

12 December 2020

Inflammatory processes in Alzheimer's disease

1 reference

12 December 2020

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

1 reference

12 December 2020

The galvanization of beta-amyloid in Alzheimer's disease

1 reference

12 December 2020

Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation

1 reference

12 December 2020

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

1 reference

12 December 2020

The role of neurotrophins and insulin on tau pathology in Alzheimer's disease

1 reference

12 December 2020

Brain inflammation, cholesterol, and glutamate as interconnected participants in the pathology of Alzheimer's disease.

1 reference

12 December 2020

Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation.

1 reference

12 December 2020

Activity-dependent neuroprotective protein: from gene to drug candidate

1 reference

12 December 2020

Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative diseases

1 reference

12 December 2020

Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.

1 reference

12 December 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

12 December 2020

Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

1 reference

12 December 2020

Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies.

1 reference

12 December 2020

5-HT6 receptors: a novel target for cognitive enhancement

1 reference

12 December 2020

Taxol stabilizes [Ca2+]i and protects hippocampal neurons against excitotoxicity

1 reference

12 December 2020

A specific amyloid-beta protein assembly in the brain impairs memory

1 reference

12 December 2020

Schizophrenia and the alpha7 nicotinic acetylcholine receptor

1 reference

12 December 2020

Targeting soluble Abeta peptide with Tramiprosate for the treatment of brain amyloidosis.

1 reference

12 December 2020

Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model

1 reference

12 December 2020

Glycogen synthase kinase-3 inhibition is integral to long-term potentiation.

1 reference

12 December 2020

M<sub>1</sub> Muscarinic Agonists Can Modulate Some of the Hallmarks in Alzheimer's Disease: Implications in Future Therapy

1 reference

12 December 2020

A clinical overview of cholinesterase inhibitors in Alzheimer's disease.

1 reference

12 December 2020

Efficacy of MEM 1003, a novel calcium channel blocker, in delay and trace eyeblink conditioning in older rabbits.

1 reference

12 December 2020

Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats

1 reference

12 December 2020

Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes

1 reference

12 December 2020

Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau.

1 reference

12 December 2020

Tau suppression in a neurodegenerative mouse model improves memory function

1 reference

12 December 2020

Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase

1 reference

12 December 2020

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

1 reference

12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

12 December 2020

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

1 reference

12 December 2020

Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms.

1 reference

12 December 2020

Insulin resistance syndrome and Alzheimer disease: pathophysiologic mechanisms and therapeutic implications

1 reference

12 December 2020

{beta}-Amyloid-induced neurodegeneration and protection by structurally diverse microtubule-stabilizing agents.

1 reference

12 December 2020

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

1 reference

12 December 2020

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

1 reference

12 December 2020

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice.

1 reference

12 December 2020

Measuring morphological and cellular changes in Alzheimer's dementia: a review emphasizing stereology

1 reference

12 December 2020

Ginkgo biloba extract EGb 761 in dementia: intent-to-treat analyses of a 24-week, multi-center, double-blind, placebo-controlled, randomized trial.

1 reference

12 December 2020

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

12 December 2020

Diagnostic criteria for the neuropathologic assessment of Alzheimer's disease

1 reference

12 December 2020

Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity

1 reference

12 December 2020

Incidence and predictors of seizures in patients with Alzheimer's disease

1 reference

12 December 2020

Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

1 reference

12 December 2020

One hundred years after the discovery of Alzheimer's disease. A turning point for therapy?

1 reference

12 December 2020

The cholinergic system in Alzheimer's disease

1 reference

12 December 2020

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

1 reference

12 December 2020

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

1 reference

12 December 2020

Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent

1 reference

12 December 2020

List of drugs in development for neurodegenerative diseases. Update June 2006

1 reference

12 December 2020

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

1 reference

12 December 2020

L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors.

1 reference

12 December 2020

Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group.

1 reference

12 December 2020

Peripheral neuropathy due to biweekly paclitaxel, epirubicin and cisplatin in patients with advanced ovarian cancer

1 reference

12 December 2020

Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge

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12 December 2020

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

1 reference

12 December 2020

1 reference

12 December 2020

Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane

1 reference

12 December 2020

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

1 reference

12 December 2020

Alzheimer's disease and the aging brain

1 reference

12 December 2020

Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior

1 reference

12 December 2020

Pathways by which Abeta facilitates tau pathology

1 reference

12 December 2020

Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

1 reference

12 December 2020

Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease

1 reference

12 December 2020

Tau therapeutic strategies for the treatment of Alzheimer's disease

1 reference

12 December 2020

Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists.

1 reference

12 December 2020

Histamine H3 receptor ligands break ground in a remarkable plethora of therapeutic areas

1 reference

12 December 2020

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

12 December 2020