(Q84966141)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19949934%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

Generating inhibitors of P-glycoprotein: where to, now? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19949934%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

author

Christopher A McDevitt

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19949934%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

Richard Callaghan

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19949934%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

author name string

Emily Crowley

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19949934%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

publication date

1 January 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19949934%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

number of pages

28

1 reference

Methods in Molecular Biology

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19949934%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

volume

596

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19949934%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

page(s)

405-432

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19949934%20AND%20SRC:MED&resulttype=core&format=json

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

13 February 2020

cites work

1 reference

12 December 2020

Effects of quinidine and related compounds on cytotoxicity and cellular accumulation of vincristine and adriamycin in drug-resistant tumor cells

1 reference

12 December 2020

Enhancement of sensitivity to adriamycin in resistant P388 leukemia by the calmodulin inhibitor trifluoperazine.

1 reference

12 December 2020

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1 reference

12 December 2020

Progress in understanding the structure-activity relationships of P-glycoprotein

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12 December 2020

Advances in flavonoid research since 1992.

1 reference

12 December 2020

Strategies for overcoming p-glycoprotein-mediated drug resistance in acute myeloblastic leukaemia

1 reference

12 December 2020

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

1 reference

12 December 2020

Phase I trial of high-dose tamoxifen as a modulator of drug resistance in combination with daunorubicin in patients with relapsed or refractory acute leukemia.

1 reference

12 December 2020

Domain mapping of the photoaffinity drug-binding sites in P-glycoprotein encoded by mouse mdr1b.

1 reference

12 December 2020

Phase I and pharmacokinetic study of paclitaxel in combination with biricodar, a novel agent that reverses multidrug resistance conferred by overexpression of both MDR1 and MRP.

1 reference

12 December 2020

Optimizing chemotherapy by measuring reversal of P-glycoprotein activity in plasma membrane vesicles

1 reference

12 December 2020

Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720.

1 reference

12 December 2020

Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response

1 reference

12 December 2020

The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

1 reference

12 December 2020

P-glycoprotein possesses a 1,4-dihydropyridine-selective drug acceptor site which is alloserically coupled to a vinca-alkaloid-selective binding site

1 reference

12 December 2020

Mechanisms of drug resistance in cancer chemotherapy

1 reference

12 December 2020

Phase I study of docetaxel in combination with the P-glycoprotein inhibitor, zosuquidar, in resistant malignancies

1 reference

12 December 2020

Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine.

1 reference

12 December 2020

1 reference

12 December 2020

Tumor stroma and regulation of cancer development

1 reference

12 December 2020

The orally administered P-glycoprotein inhibitor R101933 does not alter the plasma pharmacokinetics of docetaxel.

1 reference

12 December 2020

Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket

1 reference

12 December 2020

The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

1 reference

12 December 2020

Pharmacophore discovery--lessons learned

1 reference

12 December 2020

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

1 reference

12 December 2020

Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators

1 reference

12 December 2020

Relevance of multidrug resistance proteins on the clinical efficacy of cancer therapy

1 reference

12 December 2020

Ventricular arrhythmia and torsade de pointe: dose limiting toxicities of the MDR-modulator S9788 in a phase I trial.

1 reference

12 December 2020

Structure of the multidrug ABC transporter Sav1866 from Staphylococcus aureus in complex with AMP-PNP

1 reference

12 December 2020

Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer.

1 reference

12 December 2020

Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1.

1 reference

12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

12 December 2020

The importance of a nitrogen atom in modulators of multidrug resistance

1 reference

12 December 2020

Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates

1 reference

12 December 2020

Multidrug resistance in cancer: its mechanism and its modulation.

1 reference

12 December 2020

Two transport binding sites of P-glycoprotein are unequal yet contingent: initial rate kinetic analysis by ATP hydrolysis demonstrates intersite dependence

1 reference

12 December 2020

Inhibition of P-glycoprotein function by XR9576 in a solid tumour model can restore anticancer drug efficacy

1 reference

12 December 2020

Reversal of P-glycoprotein mediated multidrug resistance by novel anthranilamide derivatives

1 reference

12 December 2020

Lead identification for modulators of multidrug resistance based on in silico screening with a pharmacophoric feature model

1 reference

12 December 2020

Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants

1 reference

12 December 2020

A genetic algorithm for flexible molecular overlay and pharmacophore elucidation.

1 reference

12 December 2020

An inward-facing conformation of a putative metal-chelate-type ABC transporter

1 reference

12 December 2020

Reduced cyclosporin accumulation in multidrug-resistant cells.

1 reference

12 December 2020

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

1 reference

12 December 2020

RS-33295-198: a novel, potent modulator of P-glycoprotein-mediated multidrug resistance

1 reference

12 December 2020

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

1 reference

12 December 2020

About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work

1 reference

12 December 2020

A phase I/II study of the MDR modulator Valspodar (PSC 833) combined with daunorubicin and cytarabine in patients with relapsed and primary refractory acute myeloid leukemia

1 reference

12 December 2020

Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin A

1 reference

12 December 2020

Structure of a bacterial multidrug ABC transporter

1 reference

12 December 2020

Allosteric modulation of human P-glycoprotein. Inhibition of transport by preventing substrate translocation and dissociation

1 reference

12 December 2020

A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein

1 reference

12 December 2020

Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)

1 reference

12 December 2020

Communication between multiple drug binding sites on P-glycoprotein

1 reference

12 December 2020

The role of the EGFR signaling in tumor microenvironment.

1 reference

12 December 2020

Competitive and allosteric interactions in ligand binding to P-glycoprotein as observed on an immobilized P-glycoprotein liquid chromatographic stationary phase.

1 reference

12 December 2020

Allosteric modulation bypasses the requirement for ATP hydrolysis in regenerating low affinity transition state conformation of human P-glycoprotein

1 reference

12 December 2020

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1 reference

12 December 2020

Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance.

1 reference

12 December 2020

Understanding of known drug-target interactions in the catalytic pocket of neuraminidase subtype N1.

1 reference

12 December 2020

Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

1 reference

12 December 2020

Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents

1 reference

12 December 2020

In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.

1 reference

12 December 2020

The interplay between MYC and HIF in cancer.

1 reference

12 December 2020

Biochemical and pharmacological properties of an allosteric modulator site of the human P-glycoprotein (ABCB1)

1 reference

12 December 2020

Dietary flavonoids: effects on xenobiotic and carcinogen metabolism

1 reference

12 December 2020

Resistance to chemotherapy in cancer: a complex and integrated cellular response

1 reference

12 December 2020

Structure of the catalytic and antigenic sites in influenza virus neuraminidase

1 reference

12 December 2020

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone

1 reference

12 December 2020

Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins

1 reference

12 December 2020

Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues. Analysis with 3 monoclonal antibodies recognizing different epitopes of the P-glycoprotein molecule

1 reference

12 December 2020

Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel

1 reference

12 December 2020

Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket

1 reference

12 December 2020

Structural studies of the resistance of influenza virus neuramindase to inhibitors

1 reference

12 December 2020

P-Glycoprotein Expression as a Predictor of the Outcome of Therapy for Neuroblastoma

1 reference

12 December 2020

Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols

1 reference

12 December 2020

Discovery and characterization of OC144-093, a novel inhibitor of P-glycoprotein-mediated multidrug resistance.

1 reference

12 December 2020

Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by perhexiline maleate

1 reference

12 December 2020

P-glycoprotein expression: critical determinant in the response to osteosarcoma chemotherapy

1 reference

12 December 2020

P-glycoprotein plays a role in the oral absorption of BMS-387032, a potent cyclin-dependent kinase 2 inhibitor, in rats

1 reference

12 December 2020

Phase I study of vinblastine and verapamil given by concurrent iv infusion

1 reference

12 December 2020

Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

1 reference

12 December 2020

New triazine derivatives as potent modulators of multidrug resistance

1 reference

12 December 2020

Overview of resistance to systemic therapy in patients with breast cancer

1 reference

12 December 2020

Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinoma

1 reference

12 December 2020

Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

1 reference

12 December 2020

Computational models for prediction of interactions with ABC-transporters

1 reference

12 December 2020

Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection

1 reference

12 December 2020

Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

1 reference

12 December 2020

A fast new approach to pharmacophore mapping and its application to dopaminergic and benzodiazepine agonists.

1 reference

12 December 2020

Recent progress in understanding the mechanism of P-glycoprotein-mediated drug efflux.

1 reference

12 December 2020

Drug-grapefruit juice interactions

1 reference

12 December 2020

Synthesis and biological evaluation of pentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane derivatives as potential therapeutic agents in Parkinson's disease

1 reference

12 December 2020

Evidence for a Sav1866-like architecture for the human multidrug transporter P-glycoprotein

1 reference

12 December 2020

Inhibitory effect of fruit extracts on P-glycoprotein-related efflux carriers: an in-vitro screening.

1 reference

12 December 2020

Modern management of small-cell lung cancer

1 reference

12 December 2020

The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor

1 reference

12 December 2020

Essential features of the P-glycoprotein pharmacophore as defined by a series of reserpine analogs that modulate multidrug resistance

1 reference

12 December 2020

An atomic detail model for the human ATP binding cassette transporter P‐glycoprotein derived from disulphide cross‐ linking and homology modeling

1 reference

12 December 2020

Application of a Theory of Enzyme Specificity to Protein Synthesis

1 reference

12 December 2020

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil

1 reference

12 December 2020

In silico screening with benzofurane- and benzopyrane-type MDR-modulators

1 reference

12 December 2020

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

1 reference

12 December 2020

Enhancement of vincristine- and adriamycin-induced cytotoxicity by verapamil in P388 leukemia and its sublines resistant to vincristine and adriamycin.

1 reference

12 December 2020

Three-dimensional structures of the mammalian multidrug resistance P-glycoprotein demonstrate major conformational changes in the transmembrane domains upon nucleotide binding

1 reference

12 December 2020

A phase II study of epidoxorubicin in colorectal cancer and the use of cyclosporin-A in an attempt to reverse multidrug resistance

1 reference

12 December 2020

P-glycoprotein recognition of substrates and circumvention through rational drug design

1 reference

12 December 2020

Structural determinants of P-glycoprotein-mediated transport of glucocorticoids

1 reference

12 December 2020

Zanamivir for the prevention of influenza in adults and children age 5 years and older.

1 reference

12 December 2020

Pharmacogenetics of acute lymphoblastic leukemia treatment response

1 reference

12 December 2020

Identification of drug interaction sites in P-glycoprotein

1 reference

12 December 2020

P-glycoprotein models of the apo and ATP-bound states based on homology with Sav1866 and MalK

1 reference

12 December 2020

Phase I trial of doxorubicin with cyclosporine as a modulator of multidrug resistance.

1 reference

12 December 2020

Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry.

1 reference

12 December 2020

Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor

1 reference

12 December 2020

Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.

1 reference

12 December 2020

Assessment of the P-glycoprotein expression by 99mTc-MIBI bone marrow imaging in patients with untreated leukaemia

1 reference

12 December 2020

Structure and mechanism of ABC transporter proteins.

1 reference

12 December 2020

Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

1 reference

12 December 2020

The translocation mechanism of P-glycoprotein.

1 reference

12 December 2020

Prediction of the response to chemotherapy in ovarian cancers

1 reference

12 December 2020

Structure-activity relationships for xenobiotic transport substrates and inhibitory ligands of P-glycoprotein

1 reference

12 December 2020

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

1 reference

12 December 2020

Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).

1 reference

12 December 2020

A structure-function relationship among reserpine and yohimbine analogues in their ability to increase expression of mdr1 and P-glycoprotein in a human colon carcinoma cell line

1 reference

12 December 2020

Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump

1 reference

12 December 2020

Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution

1 reference

12 December 2020

Characterization of two pharmacophores on the multidrug transporter P-glycoprotein

1 reference

12 December 2020

Predicting the three-dimensional structure of human P-glycoprotein in absence of ATP by computational techniques embodying crosslinking data: insight into the mechanism of ligand migration and binding sites.

1 reference

12 December 2020

A computational procedure for determining energetically favorable binding sites on biologically important macromolecules

1 reference

12 December 2020

The ATP switch model for ABC transporters

1 reference

12 December 2020

Importance of P-glycoprotein for drug disposition in humans

1 reference

12 December 2020

Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization

1 reference

12 December 2020

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

1 reference

12 December 2020

Major photoaffinity drug labeling sites for iodoaryl azidoprazosin in P-glycoprotein are within, or immediately C-terminal to, transmembrane domains 6 and 12.

1 reference

12 December 2020

Gefitinib, an EGFR tyrosine kinase inhibitor, directly inhibits the function of P-glycoprotein in multidrug resistant cancer cells.

1 reference

12 December 2020

Do structurally similar molecules have similar biological activity?

1 reference

12 December 2020

Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis

1 reference

12 December 2020

Flavonoid-drug interactions: effects of flavonoids on ABC transporters

1 reference

12 December 2020

Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycoprotein

1 reference

12 December 2020

The vinblastine binding site adopts high- and low-affinity conformations during a transport cycle of P-glycoprotein

1 reference

12 December 2020

Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer

1 reference

12 December 2020

Phase I study of the multidrug resistance inhibitor zosuquidar administered in combination with vinorelbine in patients with advanced solid tumours

1 reference

12 December 2020

Nucleotide-induced structural changes in P-glycoprotein observed by electron microscopy.

1 reference

12 December 2020

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1 reference

12 December 2020

Phase I trial of XR9576 in healthy volunteers demonstrates modulation of P-glycoprotein in CD56+ lymphocytes after oral and intravenous administration.

1 reference

12 December 2020

Identification of putative binding sites of P-glycoprotein based on its homology model

1 reference

12 December 2020

Targeting drug-efflux pumps -- a pharmacoinformatic approach.

1 reference

12 December 2020

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

1 reference

12 December 2020

Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors

1 reference

12 December 2020

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1 reference

12 December 2020

A phase I pharmacokinetic study of the P-glycoprotein inhibitor, ONT-093, in combination with paclitaxel in patients with advanced cancer.

1 reference

12 December 2020

Efficacies of tea components on doxorubicin induced antitumor activity and reversal of multidrug resistance.

1 reference

12 December 2020

Mechanism of ABC transporters: a molecular dynamics simulation of a well characterized nucleotide-binding subunit

1 reference

12 December 2020

Drug resistance, predictive markers and pharmacogenomics in colorectal cancer

1 reference

12 December 2020

Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

1 reference

12 December 2020

The prognostic significance of membrane transport-associated multidrug resistance (MDR) proteins in leukemia

1 reference

12 December 2020

The war against influenza: discovery and development of sialidase inhibitors

1 reference

12 December 2020

Drug binding sites on P-glycoprotein are altered by ATP binding prior to nucleotide hydrolysis

1 reference

12 December 2020

P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach

1 reference

12 December 2020

Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer

1 reference

12 December 2020

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs

1 reference

12 December 2020

ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

1 reference

12 December 2020

In silico pharmacology for drug discovery: applications to targets and beyond

1 reference

12 December 2020

Multispecificity of drug transporters: probing inhibitor selectivity for the human drug efflux transporters ABCB1 and ABCG2.

1 reference

12 December 2020

A dose-finding and pharmacokinetic study of reversal of multidrug resistance with SDZ PSC 833 in combination with doxorubicin in patients with solid tumors.

1 reference

12 December 2020

The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosis

1 reference

12 December 2020

Asymmetry in the structure of the ABC transporter-binding protein complex BtuCD-BtuF

1 reference

12 December 2020

Crystal structure of a catalytic intermediate of the maltose transporter

1 reference

12 December 2020

Computational approaches to modeling drug transporters.

1 reference

12 December 2020

A general pattern for substrate recognition by P-glycoprotein.

1 reference

12 December 2020

Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B: systematic review and meta-analyses of randomised controlled trials

1 reference

12 December 2020

Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance.

1 reference

12 December 2020

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

1 reference

12 December 2020

P-glycoprotein: so many ways to turn it on.

1 reference

12 December 2020

Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport

1 reference

12 December 2020

Projection structure of P-glycoprotein by electron microscopy. Evidence for a closed conformation of the nucleotide binding domains

1 reference

12 December 2020

Effect of dietary flavonoids on pathways involved in drug metabolism

1 reference

12 December 2020

Rapid Identification of P-glycoprotein Substrates and Inhibitors

1 reference

12 December 2020

The Role of ABC Transporters in Clinical Practice

1 reference

12 December 2020

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

12 December 2020

Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein

1 reference

12 December 2020

99mTc-Sestamibi, a sensitive probe for in vivo imaging of P-glycoprotein inhibition by modulators and mdr1 antisense oligodeoxynucleotides.

1 reference

12 December 2020

P-glycoprotein substrates and antagonists cluster into two distinct groups

1 reference

12 December 2020

Three-dimensional structure of P-glycoprotein: the transmembrane regions adopt an asymmetric configuration in the nucleotide-bound state.

1 reference

12 December 2020

Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein

1 reference

12 December 2020

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

1 reference

12 December 2020

Hypoxia-inducible factors and cancer.

1 reference

12 December 2020

Thermodynamic analysis of degenerate recognition by the NKG2D immunoreceptor: not induced fit but rigid adaptation

1 reference

12 December 2020

Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells

1 reference

12 December 2020