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Interferon target-gene expression and epigenomic signatures in health and disease
scientific article published on 19 November 2019
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31745335
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21 April 2020
review article
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title
Interferon target-gene expression and epigenomic signatures in health and disease
(English)
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Europe PubMed Central
PubMed ID
31745335
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21 April 2020
author
Lionel B Ivashkiv
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3
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31745335
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21 April 2020
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Franck J Barrat
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1
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Europe PubMed Central
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31745335
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21 April 2020
Mary K Crow
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2
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31745335
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21 April 2020
publication date
19 November 2019
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21 April 2020
published in
Nature Immunology
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PubMed ID
31745335
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21 April 2020
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20
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31745335
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21 April 2020
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1574-1583
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31745335
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21 April 2020
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12
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21 April 2020
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reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of alterations in macrophage activation associated with disease activity in systemic lupus erythematosus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of Long Interspersed Nuclear Element 1 Retroelements and Induction of Type I Interferon in Patients With Systemic Autoimmune Disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of distinct gene expression profiles in the synovium of patients with systemic lupus erythematosus.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The immune cell landscape in kidneys of patients with lupus nephritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional assay of type I interferon in systemic lupus erythematosus plasma and association with anti-RNA binding protein autoantibodies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of novel oligonucleotides from mitochondrial DNA that spontaneously induce plasmacytoid dendritic cell activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation of DNASE1 in people with systemic lupus erythematosus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Trex1 prevents cell-intrinsic initiation of autoimmunity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 2 trial
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prediction of autoimmune connective tissue disease in an at-risk cohort: prognostic value of a novel two-score system for interferon status
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential expression of Ia antigens by rheumatoid synovial lining cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Machine learning integration of rheumatoid arthritis synovial histology and RNAseq data identifies three disease subtypes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HBEGF macrophages in rheumatoid arthritis induce fibroblast invasiveness
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that gamma-interferon is not the primary macrophage activating factor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Systemic sclerosis: a prototypic multisystem fibrotic disorder
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A longitudinal biomarker for the extent of skin disease in patients with diffuse cutaneous systemic sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Changes in plasma CXCL4 levels are associated with improvements in lung function in patients receiving immunosuppressive therapy for systemic sclerosis-related interstitial lung disease
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An IFN-associated cytotoxic cellular immune response against viral, self-, or tumor antigens is a common pathogenetic feature in "interface dermatitis".
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Self-Awareness: Nucleic Acid-Driven Inflammation and the Type I Interferonopathies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activated STING in a vascular and pulmonary syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial double-stranded RNA triggers antiviral signalling in humans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Efficacy of Baricitinib in the Treatment of Chilblains Associated With Aicardi-Goutières Syndrome, a Type I Interferonopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Pathogenesis of macrophage activation syndrome and potential for cytokine- directed therapies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Editorial: interferon-γ: friend or foe in systemic juvenile idiopathic arthritis and adult-onset Still's Disease?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Brief Report: Interferon-γ-Mediated Immunopathology Potentiated by Toll-Like Receptor 9 Activation in a Murine Model of Macrophage Activation Syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Treatment of refractory hemophagocytic lymphohistiocytosis with emapalumab despite severe concurrent infections
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Emapalumab: First Global Approval
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FS41590-019-0466-2
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/S41590-019-0466-2
1 reference
stated in
Europe PubMed Central
PubMed ID
31745335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31745335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
PubMed ID
31745335
1 reference
stated in
Europe PubMed Central
PubMed ID
31745335
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31745335%20AND%20SRC:MED&resulttype=core&format=json
retrieved
21 April 2020
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