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Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets
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Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets
(English)
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author name string
V. M.-Y. Lee
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1
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K. R. Brunden
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2
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M. Hutton
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3
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J. Q. Trojanowski
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English
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September 2011
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Cold Spring Harbor Perspectives in Medicine
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1
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a006437
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1
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CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival
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Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy
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28 September 2017
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28 September 2017
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Nucleation-dependent tau filament formation: the importance of dimerization and an estimation of elementary rate constants
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Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression
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28 September 2017
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Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.
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28 September 2017
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28 September 2017
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28 September 2017
Autophagy in neurodegenerative disease: friend, foe or turncoat?
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28 September 2017
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.
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28 September 2017
An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice
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28 September 2017
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
Mutations causing neurodegenerative tauopathies
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
Post-translational modifications of tau protein in Alzheimer's disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
Template-assisted filament growth by parallel stacking of tau.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
Targeting multiple signal transduction pathways through inhibition of Hsp90.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
Phosphorylation of tau by fyn: implications for Alzheimer's disease.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
Nonlinear accumulation in the brain of the new taxoid TXD258 following saturation of P-glycoprotein at the blood-brain barrier in mice and rats.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
Chaperones increase association of tau protein with microtubules
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
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28 September 2017
A decade of CDK5.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 September 2017
Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 September 2017
Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 September 2017
Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 September 2017
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 September 2017
Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 September 2017
Staging of Alzheimer-related cortical destruction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 September 2017
Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 September 2017
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 September 2017
Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 September 2017
Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 September 2017
Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
Physiology and pathology of tau protein kinases in relation to Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
Proline-directed and non-proline-directed phosphorylation of PHF-tau.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
Phosphate analysis and dephosphorylation of modified tau associated with paired helical filaments
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
Structure and novel exons of the human tau gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
31 May 2018
Bapineuzumab in Alzheimer's disease: where now?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Rapamycin alleviates toxicity of different aggregate-prone proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Cdk5 is a key factor in tau aggregation and tangle formation in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins--a role in nuclear localization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Plaques, tangles and dementia. A quantitative study.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3234455
retrieved
28 November 2018
Paclitaxel and docetaxel in the treatment of breast cancer
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stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22229117
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22229117
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22229117
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Phase II Trial of Ixabepilone, an Epothilone B Analog, in Patients With Metastatic Breast Cancer Previously Untreated With Taxanes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22229117
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22229117
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Effect of increased glycogen synthase kinase-3 activity upon the maturation of the amyloid precursor protein in transfected cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22229117
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22229117
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxel
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22229117
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22229117
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22229117
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22229117
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Domains of tau protein and interactions with microtubules
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22229117
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1101/CSHPERSPECT.A006437
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4443697
OpenCitations bibliographic resource ID
4443697
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4443697
PMCID
3234455
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4443697
PubMed ID
22229117
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4443697
ResearchGate publication ID
221732948
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