(Q35679775)

9 August 2017

1 reference

title

Tumour-suppressor function in the nervous system (English)

1 reference

9 August 2017

Suzanne J Baker

1

1 reference

PubMed ID

14993900

9 August 2017

Peter J McKinnon

series ordinal

2

1 reference

PubMed ID

14993900

9 August 2017

language of work or name

English

0 references

publication date

1 March 2004

1 reference

9 August 2017

Nature Reviews Cancer

1 reference

9 August 2017

4

1 reference

9 August 2017

184-196

1 reference

9 August 2017

3

1 reference

https://scigraph.springernature.com/pub.10.1038/nrc1297

9 August 2017

0 references

cites work

Altered methylation patterns in cancer cell genomes: cause or consequence?

1 reference

Tumour-suppressor genes: evolving definitions in the genomic age

31 March 2020

1 reference

Stem cells and neurogenesis in the adult brain.

31 March 2020

1 reference

Mammalian neural stem cells

31 March 2020

1 reference

Neurogenesis in the adult brain: death of a dogma

31 March 2020

1 reference

The developmental biology of brain tumors.

31 March 2020

1 reference

The molecular and genetic basis of neurological tumours

31 March 2020

1 reference

Recent advances in the molecular genetics of primary gliomas

31 March 2020

1 reference

Genes and pathways driving glioblastomas in humans and murine disease models

31 March 2020

1 reference

Pictures in molecular medicine: contemplating Alzheimer's disease as cancer: a loss of cell-cycle control.

31 March 2020

1 reference

Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.

31 March 2020

1 reference

Cell death and the cell cycle: a relationship between transformation and neurodegeneration?

31 March 2020

1 reference

Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases

31 March 2020

1 reference

Human retinoblastoma susceptibility gene: cloning, identification, and sequence.

31 March 2020

1 reference

Structural evidence for the authenticity of the human retinoblastoma gene

31 March 2020

1 reference

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

31 March 2020

1 reference

Mutation and cancer: statistical study of retinoblastoma

31 March 2020

1 reference

Whose Hypothesis? Ciphering, Sectorials, D Lesions, Freckles and the Operation of Stigler's Law

31 March 2020

1 reference

The retinoblastoma tumour suppressor in development and cancer

31 March 2020

1 reference

The RB and p53 pathways in cancer

31 March 2020

1 reference

The retinoblastoma gene family in differentiation and development.

31 March 2020

1 reference

Coordinated regulation of life and death by RB.

31 March 2020

1 reference

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

31 March 2020

1 reference

Tumor induction and tissue atrophy in mice lacking E2F-1

31 March 2020

1 reference

E2F-1 functions in mice to promote apoptosis and suppress proliferation

31 March 2020

1 reference

Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma

31 March 2020

1 reference

Effects of an Rb mutation in the mouse

31 March 2020

1 reference

p107 is a suppressor of retinoblastoma development in pRb-deficient mice

31 March 2020

1 reference

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

31 March 2020

1 reference

Extra-embryonic function of Rb is essential for embryonic development and viability

31 March 2020

1 reference

Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb -deficient mice

31 March 2020

1 reference

Cell-autonomous and non-cell-autonomous functions of the Rb tumor suppressor in developing central nervous system

31 March 2020

1 reference

Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development

31 March 2020

1 reference

Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system

31 March 2020

1 reference

Rb regulates proliferation and rod photoreceptor development in the mouse retina

31 March 2020

1 reference

Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence.

31 March 2020

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

31 March 2020

1 reference

The phosphoinositide 3-kinase pathway

31 March 2020

1 reference

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

1 reference

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

31 March 2020

1 reference

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

31 March 2020

1 reference

Mechanisms of size control.

31 March 2020

1 reference

Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways

31 March 2020

1 reference

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

31 March 2020

1 reference

The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila

31 March 2020

1 reference

Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

31 March 2020

1 reference

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

31 March 2020

1 reference

Rheb fills a GAP between TSC and TOR.

31 March 2020

1 reference

PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome

31 March 2020

1 reference

Cowden disease and Lhermitte-Duclos disease: characterization of a new phakomatosis

31 March 2020

1 reference

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

31 March 2020

1 reference

PTEN mutations in gliomas and glioneuronal tumors.

31 March 2020

1 reference

PTEN: life as a tumor suppressor

31 March 2020

1 reference

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

31 March 2020

1 reference

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

31 March 2020

1 reference

Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production

31 March 2020

1 reference

Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

31 March 2020

1 reference

Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function

31 March 2020

1 reference

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

31 March 2020

1 reference

Developmental roles and clinical significance of hedgehog signaling

31 March 2020

1 reference

Gli and hedgehog in cancer: tumours, embryos and stem cells.

31 March 2020

1 reference

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

31 March 2020

1 reference

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

31 March 2020

1 reference

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

31 March 2020

1 reference

Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control

31 March 2020

1 reference

Genetic control of cell size

31 March 2020

1 reference

PTEN function in mammalian cell size regulation

31 March 2020

1 reference

Drosophila myc regulates cellular growth during development.

31 March 2020

1 reference

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

31 March 2020

1 reference

Regulation of neuronal survival by the serine-threonine protein kinase Akt

31 March 2020

1 reference

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

31 March 2020

1 reference

PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis

31 March 2020

1 reference

Control of synaptic strength, a novel function of Akt.

31 March 2020

1 reference

Raf and akt mediate distinct aspects of sensory axon growth

31 March 2020

1 reference

mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo

31 March 2020

1 reference

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

31 March 2020

1 reference

Neurofibromatosis 1: closing the GAP between mice and men.

31 March 2020

1 reference

Neurofibromin, a tumor suppressor in the nervous system

31 March 2020

1 reference

Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.

31 March 2020

1 reference

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

31 March 2020

1 reference

Neurofibromas in NF1: Schwann cell origin and role of tumor environment

31 March 2020

1 reference

Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

31 March 2020

1 reference

Genome maintenance mechanisms for preventing cancer

31 March 2020

1 reference

The role of DNA breaks in genomic instability and tumorigenesis

31 March 2020

1 reference

The significance of unstable chromosomes in colorectal cancer.

31 March 2020

1 reference

Mechanism and regulation of human non-homologous DNA end-joining

31 March 2020

1 reference

Molecular views of recombination proteins and their control

31 March 2020

1 reference

XRCC1 and DNA strand break repair

31 March 2020

1 reference

CHK2 kinase--a busy messenger.

31 March 2020

1 reference

Chromosomal stability and the DNA double-stranded break connection

31 March 2020

1 reference

31 March 2020

1 reference

The many substrates and functions of ATM

31 March 2020

1 reference

ATM: from gene to function

31 March 2020

1 reference

Atm-deficient mice: a paradigm of ataxia telangiectasia

31 March 2020

1 reference

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

31 March 2020

1 reference

atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity

31 March 2020

1 reference

Prevalence of germline truncating mutations in ATM in women with a second breast cancer after radiation therapy for a contralateral tumor

31 March 2020

1 reference

Heterozygous ATM mutations do not contribute to early onset of breast cancer

31 March 2020

1 reference

Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations

31 March 2020

1 reference

The molecular basis of radiosensitivity and chemosensitivity in the treatment of breast cancer

31 March 2020

1 reference

Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.

31 March 2020

1 reference

ATM mutations in sporadic lymphoid tumours.

31 March 2020

1 reference

Ataxia telangiectasia gene mutations in leukaemia and lymphoma

31 March 2020

1 reference

Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system

31 March 2020

1 reference

A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

31 March 2020

1 reference

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

31 March 2020

1 reference

Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development

31 March 2020

1 reference

Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm

31 March 2020

1 reference

Apoptosis in the nervous system

31 March 2020

1 reference

Biallelic inactivation of BRCA2 in Fanconi anemia

31 March 2020

1 reference

Shared genetic susceptibility to breast cancer, brain tumors, and Fanconi anemia

31 March 2020

1 reference

Linking DNA damage and neurodegeneration

31 March 2020

1 reference

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

31 March 2020

1 reference

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

31 March 2020

1 reference

Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability

31 March 2020

1 reference

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

31 March 2020

1 reference

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

31 March 2020

1 reference

The cellular response to DNA double-strand breaks: defining the sensors and mediators

31 March 2020

1 reference

The MRN complex: coordinating and mediating the response to broken chromosomes

31 March 2020

1 reference

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

31 March 2020

1 reference

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

31 March 2020

1 reference

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

31 March 2020

1 reference

Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma

31 March 2020

1 reference

Sensing of intermediates in V(D)J recombination by ATM.

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1297

1 reference

9 August 2017

1 reference

PubMed ID

14993900