(Q35764329)

10 August 2017

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title

Signal transduction therapeutics: relevance for Alzheimer's disease (English)

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10 August 2017

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Sandra Rebelo

4

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Sandra I. Vieira

object named as

Sandra Vieira

5

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Ana Gabriela Henriques

object named as

Ana Gabriela Henriques

3

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Margarida Fardilha

object named as

Margarida Fardilha

2

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author name string

Odete A B da Cruz e Silva

1

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10 August 2017

Edgar F da Cruz e Silva

6

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10 August 2017

publication date

1 January 2004

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Journal of Molecular Neuroscience

10 August 2017

published in

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10 August 2017

volume

23

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10 August 2017

issue

1-2

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10 August 2017

page(s)

123-142

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Bcl-2 targets protein phosphatase 1 alpha to Bad.

10 August 2017

cites work

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12 December 2020

Receptor and protein kinase C-mediated regulation of ARF binding to the Golgi complex.

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12 December 2020

Changes in protein kinases in brain aging and Alzheimer's disease. Implications for drug therapy

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12 December 2020

The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad

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12 December 2020

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein

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12 December 2020

Characterization of the catalytic subunits of the different types of polycation-stimulated protein phosphatases

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12 December 2020

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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12 December 2020

The neurobiology of slow synaptic transmission

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12 December 2020

Phosphorylation of protein phosphatase inhibitor-1 by Cdk5

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12 December 2020

Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase

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12 December 2020

Protein Phosphatases: Properties and Role in Cellular Regulation

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12 December 2020

FE65 in Alzheimer's disease: neuronal distribution and association with neurofibrillary tangles

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12 December 2020

Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways

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12 December 2020

Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus

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12 December 2020

Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR.

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12 December 2020

Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system

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12 December 2020

Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus

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12 December 2020

Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.

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12 December 2020

Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

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12 December 2020

Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1

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12 December 2020

Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1.

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12 December 2020

Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2

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12 December 2020

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.

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12 December 2020

cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein

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12 December 2020

Constitutive and protein kinase C-regulated secretory cleavage of Alzheimer's beta-amyloid precursor protein: different control of early and late events by the proteasome.

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12 December 2020

The protein kinase Cdk5. Structural aspects, roles in neurogenesis and involvement in Alzheimer's pathology

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12 December 2020

An immunohistochemical investigation of the human neostriatum in Huntington's disease

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12 December 2020

Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.

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12 December 2020

The structure and regulation of protein phosphatases

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12 December 2020

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit

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12 December 2020

Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease

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12 December 2020

HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint

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12 December 2020

Proteasome contributes to the alpha-secretase pathway of amyloid precursor protein in human cells

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12 December 2020

Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.

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12 December 2020

Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C.

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12 December 2020

Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion

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12 December 2020

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells

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12 December 2020

DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1

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12 December 2020

Modelling Alzheimer-specific abnormal Tau phosphorylation independently of GSK3beta and PKA kinase activities.

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12 December 2020

Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

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12 December 2020

Characterization of polyclonal antibodies to brain protein phosphatase 2A and immunohistochemical localization of the enzyme in rat brain

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12 December 2020

Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton

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12 December 2020

Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

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12 December 2020

The major myosin phosphatase in skeletal muscle is a complex between the beta-isoform of protein phosphatase 1 and the MYPT2 gene product

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12 December 2020

The metabotropic glutamate receptor mGluR7b binds to the catalytic gamma-subunit of protein phosphatase 1.

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12 December 2020

Inhibition of tau phosphorylating protein kinase cdk5 prevents beta-amyloid-induced neuronal death

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12 December 2020

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

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12 December 2020

Isolation and sequence analysis of a cDNA clone encoding the entire catalytic subunit of a type-2A protein phosphatase

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12 December 2020

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity

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12 December 2020

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

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12 December 2020

Identification of a novel protein phosphatase catalytic subunit by cDNA cloning

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12 December 2020

Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function

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12 December 2020

The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement

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12 December 2020

X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion

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12 December 2020

PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein

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12 December 2020

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

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12 December 2020

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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12 December 2020

The regulation and function of protein phosphatases in the brain

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12 December 2020

Protein phosphatase 1--targeted in many directions

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12 December 2020

Processing of Alzheimer A beta-amyloid precursor protein: cell biology, regulation, and role in Alzheimer disease

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12 December 2020

Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling

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12 December 2020

Gleevec inhibits β-amyloid production but not Notch cleavage

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12 December 2020

GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA

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12 December 2020

Life and death of neurons in the aging brain

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12 December 2020

Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and phosphorylates inhibitor-2

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12 December 2020

Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein

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12 December 2020

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

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12 December 2020

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

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12 December 2020

Molecular cloning of a novel phosphorylation-dependent inhibitory protein of protein phosphatase-1 (CPI17) in smooth muscle: its specific localization in smooth muscle

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12 December 2020

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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12 December 2020

Phorbol esters but not the cholinergic agonists oxotremorine-M and carbachol increase release of the amyloid precursor protein in cultured rat cortical neurons.

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12 December 2020

A pool of beta-tubulin is hyperphosphorylated at serine residues in Alzheimer disease brain

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12 December 2020

Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein

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12 December 2020

Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth

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12 December 2020

Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles.

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12 December 2020

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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12 December 2020

Regulation of secretion of Alzheimer amyloid precursor protein by the mitogen-activated protein kinase cascade

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12 December 2020

Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease

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12 December 2020

Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1

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12 December 2020

Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

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12 December 2020

Multiple interactions within the AKAP220 signaling complex contribute to protein phosphatase 1 regulation

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12 December 2020

Abnormal Tau phosphorylation of the Alzheimer-type also occurs during mitosis.

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12 December 2020

Cleavage of amyloid beta peptide during constitutive processing of its precursor

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12 December 2020

A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein

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12 December 2020

Amyloid precursor protein processing is separately regulated by protein kinase C and tyrosine kinase in human astrocytes

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12 December 2020

Identification of sds22 as an inhibitory subunit of protein phosphatase-1 in rat liver nuclei

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12 December 2020

Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

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12 December 2020

Differential expression of protein phosphatase 1 isoforms in mammalian brain.

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12 December 2020

Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus

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12 December 2020

Regulation by phorbol esters of amyloid precursor protein release from Swiss 3T3 fibroblasts overexpressing protein kinase C alpha.

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12 December 2020

Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53

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12 December 2020

Function of a calmodulin in postsynaptic densities. II. Presence of a calmodulin-activatable protein kinase activity

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12 December 2020

Distribution of beta-amyloid precursor and B-cell lymphoma protooncogene proteins in the rat retina after optic nerve transection or vascular lesion

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12 December 2020

What are the relations between Lewy body disease and AD?

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12 December 2020

BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain

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12 December 2020

The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled

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12 December 2020

Phosphoprotein phosphatase activities in Alzheimer disease brain

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12 December 2020

A second catalytic subunit of type-2A protein phosphatase from rabbit skeletal muscle

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12 December 2020

Receptor-coupled amyloid precursor protein processing

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12 December 2020

PP1 gamma 2, a testis-specific protein-serine/threonine-phosphatase type 1 catalytic subunit, is associated with a protein having high sequence homology with the 78-kDa glucose-regulated protein, a member of the 70-kDa heat shock protein family

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12 December 2020

Regulation of amyloid precursor protein cleavage

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12 December 2020

Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein.

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12 December 2020

Function of a calmodulin in postsynaptic densities. III. Calmodulin-binding proteins of the postsynaptic density

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12 December 2020

The distribution of calcineurin in rat brain by light and electron microscopic immunohistochemistry and enzyme-immunoassay

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12 December 2020

In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta

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12 December 2020

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

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12 December 2020

Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

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12 December 2020

Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines

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12 December 2020

Molecular analysis of the X11-mLin-2/CASK complex in brain

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12 December 2020

Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail

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12 December 2020

Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.

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12 December 2020

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

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12 December 2020

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor

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12 December 2020

Rapid purification of calmodulin and S-100 protein by affinity chromatography with melittin immobilized to sepharose

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12 December 2020

Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease

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12 December 2020

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

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12 December 2020

G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

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12 December 2020

Amyloid precursor protein in unique cholesterol-rich microdomains different from caveolae-like domains

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12 December 2020

Mena is required for neurulation and commissure formation

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12 December 2020

Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain

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12 December 2020

Combinatorial control of protein phosphatase-1

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12 December 2020

Protein phosphorylation and APP metabolism

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12 December 2020

Evidence for a role of the nerve growth factor receptor TrkA in tyrosine phosphorylation and processing of beta-APP.

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12 December 2020

Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain.

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12 December 2020

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

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12 December 2020

Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

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12 December 2020

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

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12 December 2020

Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein

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12 December 2020

Monitoring protein phosphatase 1 isoform levels as a marker for cellular stress

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12 December 2020

Budding from Golgi membranes requires the coatomer complex of non-clathrin coat proteins

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12 December 2020

The release of Alzheimer's disease beta amyloid peptide is reduced by phorbol treatment.

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12 December 2020

Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

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12 December 2020

Neurofilament and neural cell adhesion molecule immunocytochemistry of Huntington's disease striatum

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12 December 2020

The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene

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12 December 2020

Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein

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12 December 2020

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

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12 December 2020

Amyloid beta-peptide is produced by cultured cells during normal metabolism

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12 December 2020

Calmodulin-dependent protein phosphatase: a developmental study

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12 December 2020

Phosphatidylinositol 3-kinase is required for the formation of constitutive transport vesicles from the TGN

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12 December 2020

The alpha and gamma 1 isoforms of protein phosphatase 1 are highly and specifically concentrated in dendritic spines

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12 December 2020

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

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12 December 2020

The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation

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12 December 2020

Amyloid beta peptide formation in cell-free preparations. Regulation by protein kinase C, calmodulin, and calcineurin.

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12 December 2020

A second heat-stable protein inhibitor of phosphorylase phosphatase from rabbit muscle

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12 December 2020

Up-regulation of calcineurin Abeta mRNA in the Alzheimer's disease brain: assessment by cDNA microarray

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12 December 2020

Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

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12 December 2020

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

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12 December 2020

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

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12 December 2020

Protein phosphatase 1 is a molecular constraint on learning and memory.

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12 December 2020

A specific substrate from rabbit cerebellum for guanosine-3‘:5‘-monophosphate-dependent protein kinase. III. Amino acid sequences at the two phosphorylation sites

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12 December 2020

Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations

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12 December 2020

Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1.

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12 December 2020

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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12 December 2020

The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells

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12 December 2020

Protein kinase A phosphorylation of the proteasome: a contribution to the alpha-secretase pathway in human cells

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12 December 2020

Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease

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12 December 2020

Brain actin-associated protein phosphatase 1 holoenzymes containing spinophilin, neurabin, and selected catalytic subunit isoforms

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12 December 2020

Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease

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12 December 2020

Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics

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12 December 2020

Src family tyrosine kinases participate in insulin-like growth factor I mitogenic signaling in 3T3-L1 cells.

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12 December 2020

The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.

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12 December 2020

KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine

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12 December 2020

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12 December 2020

Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau.

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12 December 2020

Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex

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12 December 2020

Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors

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12 December 2020

The role of APP processing and trafficking pathways in the formation of amyloid beta-protein

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12 December 2020

Inhibition of beta-amyloid production by activation of protein kinase C.

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12 December 2020

Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1

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12 December 2020

Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1alpha

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12 December 2020

Role of neurotransmission in the regulation of amyloid beta-protein precursor processing

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12 December 2020

Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway

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12 December 2020

Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein.

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12 December 2020

Cloning and identification of MYPT3: a prenylatable myosin targetting subunit of protein phosphatase 1

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12 December 2020

Novel protein serine/threonine phosphatases: variety is the spice of life

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12 December 2020

Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein

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12 December 2020

Abnormalities of protein kinases in neurodegenerative diseases.

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12 December 2020

Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit

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12 December 2020

Subdivisional involvement of nigrostriatal loop in idiopathic Parkinson's disease and striatonigral degeneration

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12 December 2020

The role of protein phosphorylation in beta amyloid toxicity

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12 December 2020

Human amyloid-beta causes changes in the levels of endothelial protein kinase C and its alpha isoform in vitro

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12 December 2020

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

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12 December 2020

Amyloid precursor protein secretion and beta A4 amyloid generation are not mutually exclusive

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12 December 2020

Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1

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12 December 2020

Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease.

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12 December 2020

Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells

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12 December 2020

Consensus statements on the optimal use of cyclosporine in pediatric patients

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12 December 2020

Role of tau in the polymerization of peptides from beta-amyloid precursor protein

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12 December 2020

Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease

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12 December 2020

Neurofilament-L Is a Protein Phosphatase-1-binding Protein Associated with Neuronal Plasma Membrane and Post-synaptic Density

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12 December 2020

Identifiers

DOI

10.1385/JMN:23:1-2:123

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Dimensions Publication ID

10 August 2017

1023916187

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