(Q36635195)

15 August 2017

1 reference

title

Hsp90 as a target for drug development (English)

1 reference

15 August 2017

3

Brian S J Blagg

1 reference

15 August 2017

Subhabrata Chaudhury

1

1 reference

PubMed ID

17066389

15 August 2017

Timothy R Welch

series ordinal

2

1 reference

15 August 2017

1 December 2006

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15 August 2017

1 reference

15 August 2017

1

1 reference

15 August 2017

12

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15 August 2017

1331-1340

1 reference

Inhibition of Hsp90: a new strategy for inhibiting protein kinases

15 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

Cell transformation by the viral src oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

17AAG: low target binding affinity and potent cell activity--finding an explanation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Targeting chaperones in transformed systems--a focus on Hsp90 and cancer

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Hsp90: the vulnerable chaperone

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Hsp90 inhibitors as novel cancer chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

HSP90 as a new therapeutic target for cancer therapy: the story unfolds

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Recent Advances in the Study of hsp90 Structure and Mechanism of Action

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Hsp90 & Co. - a holding for folding

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Molecular chaperones--cellular machines for protein folding

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Heat shock proteins as emerging therapeutic targets

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Targeting HSP90 to halt neurodegeneration.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Folding of newly translated proteins in vivo: the role of molecular chaperones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

The heat-shock proteins

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Heat shock proteins as virulence factors of pathogens

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Unusual expression and localization of heat-shock proteins in human tumor cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Hsp90 as a capacitor for morphological evolution

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

APPLIED OPTICS: New Ways to Guide Light

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

The common tetratricopeptide repeat acceptor site for steroid receptor-associated immunophilins and hop is located in the dimerization domain of Hsp90.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Stoichiometry, abundance, and functional significance of the hsp90/hsp70-based multiprotein chaperone machinery in reticulocyte lysate.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Stable association of hsp90 and p23, but Not hsp70, with active human telomerase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

The assembly of progesterone receptor-hsp90 complexes using purified proteins

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Differential interactions of p23 and the TPR-containing proteins Hop, Cyp40, FKBP52 and FKBP51 with Hsp90 mutants

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Cyclophilin 40 (CyP-40), mapping of its hsp90 binding domain and evidence that FKBP52 competes with CyP-40 for hsp90 binding

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Cdc37 goes beyond Hsp90 and kinases

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Domain structures and immunogenic regions of the 90-kDa heat-shock protein (HSP90). Probing with a library of anti-HSP90 monoclonal antibodies and limited proteolysis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

In vitro evidence that hsp90 contains two independent chaperone sites

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Two eukaryote-specific regions of Hsp82 are dispensable for its viability and signal transduction functions in yeast

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

GHKL, an emergent ATPase/kinase superfamily

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Constantly updated knowledge of Hsp90.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Selective Synthesis of the para-Quinone Region of Geldanamycin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Suppression of morphological transformation by radicicol is accompanied by enhanced gelsolin expression

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Halohydrin and oxime derivatives of radicicol: synthesis and antitumor activities

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Stereospecific antitumor activity of radicicol oxime derivatives

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Design, synthesis, and biological evaluation of HSP90 inhibitors based on conformational analysis of radicicol and its analogues

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Concise synthesis of pochonin A, an HSP90 inhibitor

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Orally active purine-based inhibitors of the heat shock protein 90.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

4-Amino derivatives of the Hsp90 inhibitor CCT018159.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Structure-based discovery of a new class of Hsp90 inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Radester, a novel inhibitor of the Hsp90 protein folding machinery

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Interaction of vanadate oligomers and permolybdate with the 90-kDa heat-shock protein, Hsp90

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

The interaction between coumarin drugs and DNA gyrase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

The heat shock protein 90 antagonist novobiocin interacts with a previously unrecognized ATP-binding domain in the carboxyl terminus of the chaperone

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Hsp90 inhibitors identified from a library of novobiocin analogues

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Epigallocatechin gallate inhibits aryl hydrocarbon receptor gene transcription through an indirect mechanism involving binding to a 90 kDa heat shock protein

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Shared actions of endotoxin and taxol on TNF receptors and TNF release

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

New agents in cancer clinical trials

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

High constitutive expression of heat shock protein 90α in human acute leukemia cells

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Analysis of polypeptide expression in benign and malignant human breast lesions

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Intratumoral heterogeneity for hsp90beta mRNA levels in a breast cancer cell line

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Clinical Development of 17-Allylamino, 17-Demethoxygeldanamycin

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Translating cell biology into therapeutic advances in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Role of molecular chaperones in neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Chaperones increase association of tau protein with microtubules

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Parkinson's disease: mechanisms and models

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Parkinson's disease. First of two parts

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

The scientific basis for the current treatment of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Why does remyelination fail in multiple sclerosis?

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Antibodies reactive to heat shock protein 90 induce oligodendrocyte precursor cell death in culture. Implications for demyelination in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Anti-heat shock protein 90beta antibodies decrease pre-oligodendrocyte population in perinatal and adult cell cultures. Implications for remyelination in multiple sclerosis

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Founder effect in spinal and bulbar muscular atrophy (SBMA)

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Effect of geldanamycin on androgen receptor function and stability

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600112

7 January 2021

Identifiers

DOI

10.1002/CMDC.200600112

1 reference

release_lkkfxczkbbbappwamqih453b3m

15 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/lkkfxczkbbbappwamqih453b3m

24 November 2022

mapped directly with Wikidata item

PubMed ID

17066389

1 reference

PubMed ID

17066389