(Q37310205)

19 August 2017

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title

Molecular chaperones as regulators of cell death (English)

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19 August 2017

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A Hishiya

1

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19 August 2017

S Takayama

series ordinal

2

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19 August 2017

language of work or name

English

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publication date

1 October 2008

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19 August 2017

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19 August 2017

volume

27

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19 August 2017

issue

50

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19 August 2017

page(s)

6489-6506

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CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model.

19 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Transduced human PEP-1-heat shock protein 27 efficiently protects against brain ischemic insult

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Alpha-B crystallin gene (CRYAB) mutation causes dominant congenital posterior polar cataract in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Morphological characterization of the Alpha A- and Alpha B-crystallin double knockout mouse lens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Targeted disruption of the mouse alpha A-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein alpha B-crystallin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp27 negatively regulates cell death by interacting with cytochrome c.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Mutant DNA-binding domain of HSF4 is associated with autosomal dominant lamellar and Marner cataract

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Interaction between two cellular subpopulations of a rat colonic carcinoma when inoculated to the syngeneic host.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Mutant huntingtin aggregates do not sensitize cells to apoptotic stressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Regulation of the cytoplasmic quality control protein degradation pathway by BAG2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

CHIP activates HSF1 and confers protection against apoptosis and cellular stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Cerebral ischemia and the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

The role for endoplasmic reticulum stress in diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Endosymbiotic bacteria: groEL buffers against deleterious mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

The synaptic vesicle protein CSP alpha prevents presynaptic degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Nuclear translocation of papillomavirus minor capsid protein L2 requires Hsc70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

HSF4 is required for normal cell growth and differentiation during mouse lens development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

The Hsp90 cochaperone p23 is essential for perinatal survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

A novel mutation in AlphaA-crystallin (CRYAA) caused autosomal dominant congenital cataract in a large Chinese family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Cytosolic heat shock protein 60, hypoxia, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp70 and Hsp40 chaperones do not modulate retinal phenotype in SCA7 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

BAG3 deficiency results in fulminant myopathy and early lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Demyelination, astrogliosis, and accumulation of ubiquitinated proteins, hallmarks of CNS disease in hsf1-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Insights into regulation and function of the major stress-induced hsp70 molecular chaperone in vivo: analysis of mice with targeted gene disruption of the hsp70.1 or hsp70.3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Changes in immunoreactivity of HSP60 and its neuroprotective effects in the gerbil hippocampal CA1 region induced by transient ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

The putative chaperone calmegin is required for sperm fertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp105alpha suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Escaping cell death: survival proteins in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

BAG-1 associates with the polyglutamine-expanded huntingtin aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Regulation of the human apoptotic DNase/RNase endonuclease G: involvement of Hsp70 and ATP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Induction of heat shock hsp70 mRNA and HSP70 kDa protein in neurons in the 'penumbra' following focal cerebral ischemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Amelioration of hippocampal neuronal damage after global ischemia by neuronal overexpression of BCL-2 in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Simultaneous overexpression of two stress proteins in rat cardiomyocytes and myogenic cells confers protection against ischemia-induced injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp20, a novel alpha-crystallin, prevents Abeta fibril formation and toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Targeted hsp70.1 disruption increases infarction volume after focal cerebral ischemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Effects of hsp70.1 gene knockout on the mitochondrial apoptotic pathway after focal cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Cataract mutation P20S of alphaB-crystallin impairs chaperone activity of alphaA-crystallin and induces apoptosis of human lens epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Stress induction of GRP78/BiP and its role in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Combined and individual mitochondrial HSP60 and HSP10 expression in cardiac myocytes protects mitochondrial function and prevents apoptotic cell deaths induced by simulated ischemia-reoxygenation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

ER stress and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

A novel alphaB-crystallin mutation associated with autosomal dominant congenital lamellar cataract

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Cell death triggered by a novel mutation in the alphaA-crystallin gene underlies autosomal dominant cataract linked to chromosome 21q

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Genomic buffering mitigates the effects of deleterious mutations in bacteria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Myocardial protection after whole body heat stress in the rabbit is dependent on metabolic substrate and is related to the amount of the inducible 70-kD heat stress protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Selection by trypsin of two sublines of rat colon cancer cells forming progressive or regressive tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Cytokines direct the regulation of Bim mRNA stability by heat-shock cognate protein 70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

CHIP: a link between the chaperone and proteasome systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat shock transcription factor 2 is not essential for embryonic development, fertility, or adult cognitive and psychomotor function in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Ischemia induces changes in the level of mRNAs coding for stress protein 71 and creatine kinase M.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Calreticulin is essential for cardiac development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Integrated endoplasmic reticulum stress responses in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Caspase-dependent secondary lens fiber cell disintegration in alphaA-/alphaB-crystallin double-knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Roles for αB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Modulation of neurodegeneration by molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Ischemic tolerance due to the induction of HSP70 in a rat ischemic recirculation model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Treatment with extracellular HSP70/HSC70 protein can reduce polyglutamine toxicity and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Protein ubiquitination in rat brain following hypoglycemic coma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

The cardiomyopathy and lens cataract mutation in alphaB-crystallin alters its protein structure, chaperone activity, and interaction with intermediate filaments in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Transgenic mice expressing the human inducible Hsp70 have hippocampal neurons resistant to ischemic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Transgenic mice expressing the human heat shock protein 70 have improved post-ischemic myocardial recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Cardioprotective effects of 70-kDa heat shock protein in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat-shock protein 70 antagonizes apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Transgene overexpression of alphaB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Negative regulation of the Apaf-1 apoptosome by Hsp70

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Enlarged ventricles, astrogliosis and neurodegeneration in heat shock factor 1 null mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat Shock Protein 70 Neutralization Exerts Potent Antitumor Effects in Animal Models of Colon Cancer and Melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Myofibrillar myopathy caused by novel dominant negative alpha B-crystallin mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Binding of tau to heat shock protein 27 leads to decreased concentration of hyperphosphorylated tau and enhanced cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Residue R120 is essential for the quaternary structure and functional integrity of human alphaB-crystallin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Reduction of GRP78 expression with siRNA activates unfolded protein response leading to apoptosis in HeLa cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Role of SODD in Regulation of Tumor Necrosis Factor Responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Maintenance of olfactory neurogenesis requires HSF1, a major heat shock transcription factor in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Small heat-shock protein 22 mutated in autosomal dominant Charcot-Marie-Tooth disease type 2L

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

A type I DnaJ homolog, DjA1, regulates androgen receptor signaling and spermatogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Protection against myocardial dysfunction after a brief ischemic period in transgenic mice expressing inducible heat shock protein 70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Overexpression of rat heat shock protein 70 reduces neuronal injury after transient focal ischemia, transient global ischemia, or kainic acid-induced seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Overexpression of rat heat shock protein 70 is associated with reduction of early mitochondrial cytochrome C release and subsequent DNA fragmentation after permanent focal ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Oncogenic potential of Hsp72.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Overexpression of mitochondrial Hsp70/Hsp75 protects astrocytes against ischemic injury in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Essential requirement for both hsf1 and hsf2 transcriptional activity in spermatogenesis and male fertility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Targeted disruption of the heat shock transcription factor (hsf)‐2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Prior heat stress inhibits apoptosis in adenosine triphosphate-depleted renal tubular cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Mitochondria protection from hypoxia/reoxygenation injury with mitochondria heat shock protein 70 overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Mechanism of small heat shock protein function in vivo: a knock-in mouse model demonstrates that the R49C mutation in alpha A-crystallin enhances protein insolubility and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Endoplasmic reticulum stress: cell life and death decisions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Geldanamycin reduces necrotic and apoptotic injury due to oxygen-glucose deprivation in astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Gene therapy with HSP72 is neuroprotective in rat models of stroke and epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

The induction of the TNFalpha death domain signaling pathway in Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Maternal effect of Hsf1 on reproductive success

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Nuclear cataract caused by a lack of DNA degradation in the mouse eye lens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat-shock protein 70 favours human liver recovery from ischaemia-reperfusion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Analysis of the role of heat shock protein (Hsp) molecular chaperones in polyglutamine disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Ischemia of the dog heart induces the appearance of a cardiac mRNA coding for a protein with migration characteristics similar to heat-shock/stress protein 71

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat shock protein 27 protects the heart against myocardial infarction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Upregulation of Bax protein and increased DNA degradation in ALS spinal cord motor neurons

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

HSP27 inhibits cytochrome c-dependent activation of procaspase-9.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

HSP70 heat shock protein induction following global ischemia in the rat

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Targeted disruption of the bcl-2 gene in mice exacerbates focal ischemic brain injury

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Protein aggregation after transient cerebral ischemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Induction of apoptosis by abrogation of HSP70 expression in human oral cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Role of heat shock protein 70 in hepatic ischemia-reperfusion injury in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Structural and functional consequences of the mutation of a conserved arginine residue in alphaA and alphaB crystallins

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Pancreatic beta-cell failure and diabetes in mice with a deletion mutation of the endoplasmic reticulum molecular chaperone gene P58IPK

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Identification of a CRYAB mutation associated with autosomal dominant posterior polar cataract in a Chinese family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Liposomal delivery of heat shock protein 72 into renal tubular cells blocks nuclear factor-kappaB activation, tumor necrosis factor-alpha production, and subsequent ischemia-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat shock prevents simulated ischemia-induced apoptosis in renal tubular cells via a PKC-dependent mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Over-expression of HSP-70 protects astrocytes from combined oxygen-glucose deprivation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

T cell lymphoma in transgenic mice expressing the human Hsp70 gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Overexpression of copper/zinc superoxide dismutase in transgenic rats protects vulnerable neurons against ischemic damage by blocking the mitochondrial pathway of caspase activation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Myocardial protection with endogenous overexpression of manganese superoxide dismutase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

R120G alphaB-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Heat shock protein 40/DjB1 is required for thermotolerance in early phase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

AlphaB-crystallin modulates protein aggregation of abnormal desmin

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Expression of R120G-alphaB-crystallin causes aberrant desmin and alphaB-crystallin aggregation and cardiomyopathy in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Inhibition of proliferation and induction of apoptosis by abrogation of heat-shock protein (HSP) 70 expression in tumor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.314

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.314

1 reference

19 August 2017

1 reference