(Q37502685)

20 August 2017

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title

Targeting innate immunity protein kinase signalling in inflammation (English)

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20 August 2017

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1

Matthias Gaestel

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Alexey Kotlyarov

series ordinal

2

object named as

Alexey Kotlyarov

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20 August 2017

Michael Kracht

3

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publication date

1 June 2009

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Nature Reviews Drug Discovery

20 August 2017

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20 August 2017

8

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20 August 2017

6

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20 August 2017

480-499

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https://scigraph.springernature.com/pub.10.1038/nrd2829

20 August 2017

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cites work

Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation.

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Deregulated inflammatory response in mice lacking the STK/RON receptor tyrosine kinase

21 January 2018

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Dynamic protein associations define two phases of IL-1beta transcriptional activation.

21 January 2018

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Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B

21 January 2018

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Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors

21 January 2018

1 reference

Mitogen-activated protein kinase-activated protein kinase 2-deficient mice show increased susceptibility to Listeria monocytogenes infection

21 January 2018

1 reference

MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation

21 January 2018

1 reference

Endotoxin tolerance disrupts chromatin remodeling and NF-kappaB transactivation at the IL-1beta promoter

21 January 2018

1 reference

Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation.

21 January 2018

1 reference

JNK1 is required for T cell-mediated immunity against Leishmania major infection.

21 January 2018

1 reference

Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

21 January 2018

1 reference

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

21 January 2018

1 reference

Therapeutic strategies for rheumatoid arthritis

21 January 2018

1 reference

Points of control in inflammation

31 March 2020

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Protein kinases--the major drug targets of the twenty-first century?

31 March 2020

1 reference

Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

31 March 2020

1 reference

p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure

31 March 2020

1 reference

The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

31 March 2020

1 reference

p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation

31 March 2020

1 reference

TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice

31 March 2020

1 reference

An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation

31 March 2020

1 reference

The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK.

31 March 2020

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The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

31 March 2020

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A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity

31 March 2020

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IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

31 March 2020

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A quantitative analysis of kinase inhibitor selectivity

31 March 2020

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The selectivity of protein kinase inhibitors: a further update

31 March 2020

1 reference

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors

31 March 2020

1 reference

Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms

31 March 2020

1 reference

Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.

31 March 2020

1 reference

Cartilage preservation by inhibition of Janus kinase 3 in two rodent models of rheumatoid arthritis

31 March 2020

1 reference

Structure-based design of novel 2-amino-6-phenyl-pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as potent and orally active inhibitors of lymphocyte specific kinase (Lck): synthesis, SAR, and in vivo anti-inflammatory activity

31 March 2020

1 reference

A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha

31 March 2020

1 reference

Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)

31 March 2020

1 reference

p38alpha-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation

31 March 2020

1 reference

FR180204, a novel and selective inhibitor of extracellular signal-regulated kinase, ameliorates collagen-induced arthritis in mice

31 March 2020

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Essential function for the kinase TAK1 in innate and adaptive immune responses.

31 March 2020

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Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex

31 March 2020

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Shared principles in NF-kappaB signaling

31 March 2020

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Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling

31 March 2020

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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

31 March 2020

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

31 March 2020

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Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase

31 March 2020

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Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

31 March 2020

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Interactions of NF-kappaB with chromatin: the art of being at the right place at the right time

31 March 2020

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c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene

31 March 2020

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MAPKAP kinases - MKs - two's company, three's a crowd

31 March 2020

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Jak3 negatively regulates dendritic-cell cytokine production and survival

31 March 2020

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Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

31 March 2020

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TAM receptors are pleiotropic inhibitors of the innate immune response

31 March 2020

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Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.

31 March 2020

1 reference

Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide

31 March 2020

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Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production

31 March 2020

1 reference

Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis.

31 March 2020

1 reference

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

31 March 2020

1 reference

The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes

31 March 2020

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NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

31 March 2020

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The inflammasome: a danger sensing complex triggering innate immunity

31 March 2020

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Altered cytokine production in mice lacking P2X(7) receptors

31 March 2020

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Active caspase-1 is a regulator of unconventional protein secretion

31 March 2020

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UV as an amplifier rather than inducer of NF-kappaB activity

31 March 2020

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Gout-associated uric acid crystals activate the NALP3 inflammasome

31 March 2020

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

31 March 2020

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Opposing functions of IKKbeta during acute and chronic intestinal inflammation

31 March 2020

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I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss

31 March 2020

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Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation

31 March 2020

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TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

31 March 2020

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Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

31 March 2020

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MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels

31 March 2020

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Post-transcriptional control of cytokine production

31 March 2020

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TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF in LPS-stimulated macrophages

31 March 2020

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Cytokine-induced signaling networks prioritize dynamic range over signal strength

31 March 2020

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Protein kinase inhibitors: insights into drug design from structure.

31 March 2020

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Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties

31 March 2020

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A selective p38 alpha mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis

31 March 2020

1 reference

A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice

31 March 2020

1 reference

Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokin

31 March 2020

1 reference

3-amino-7-phthalazinylbenzoisoxazoles as a novel class of potent, selective, and orally available inhibitors of p38alpha mitogen-activated protein kinase

31 March 2020

1 reference

The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors

31 March 2020

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Potential adverse effects associated with inhibition of p38alpha/beta MAP kinases

31 March 2020

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Multiple effects of acetaminophen and p38 inhibitors: towards pathway toxicology

31 March 2020

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Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial

31 March 2020

1 reference

c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice

31 March 2020

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c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression

31 March 2020

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Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

31 March 2020

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A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis

31 March 2020

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p38 MAP kinase's emerging role as a tumor suppressor

31 March 2020

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p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway

31 March 2020

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Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism

31 March 2020

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Feedback control of the protein kinase TAK1 by SAPK2a/p38

31 March 2020

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Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase

31 March 2020

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MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha

31 March 2020

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Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases

31 March 2020

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Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis

31 March 2020

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Mechanism of p38 MAP kinase activation in vivo.

31 March 2020

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Distinct cellular functions of MK2.

31 March 2020

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MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis

31 March 2020

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MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation

31 March 2020

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p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage

31 March 2020

1 reference

Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2).

31 March 2020

1 reference

The discovery of carboline analogs as potent MAPKAP-K2 inhibitors

31 March 2020

1 reference

Pyrrolo-pyrimidones: a novel class of MK2 inhibitors with potent cellular activity.

31 March 2020

1 reference

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

31 March 2020

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Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo

31 March 2020

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The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis

31 March 2020

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Local treatment with the selective IkappaB kinase beta inhibitor NEMO-binding domain peptide ameliorates synovial inflammation

31 March 2020

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A cytoplasmic inhibitor of the JNK signal transduction pathway

31 March 2020

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The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes

31 March 2020

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A mammalian scaffold complex that selectively mediates MAP kinase activation

31 March 2020

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Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

31 March 2020

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Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

31 March 2020

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Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation

31 March 2020

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Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

31 March 2020

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Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

31 March 2020

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Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

31 March 2020

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Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2

31 March 2020

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Inhibition of JNK activation through NF-kappaB target genes

31 March 2020

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Crosstalk via the NF-kappaB signaling system

31 March 2020

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A comprehensive map of the toll-like receptor signaling network

31 March 2020

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Combinatorial roles of nuclear receptors in inflammation and immunity

31 March 2020

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Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

31 March 2020

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Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids.

31 March 2020

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Negative regulation of SEK1 signaling by serum- and glucocorticoid-inducible protein kinase 1.

31 March 2020

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Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition

31 March 2020

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Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation

31 March 2020

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Efficacy of imatinib mesylate (STI571) treatment for a patient with rheumatoid arthritis developing chronic myelogenous leukemia

31 March 2020

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Historical insights into cytokines

31 March 2020

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Drug-induced lupus due to anti-tumor necrosis factor alpha agents

31 March 2020

1 reference

Autoinflammatory diseases: clinical and genetic advances

31 March 2020

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How the study of children with rheumatic diseases identified interferon-alpha and interleukin-1 as novel therapeutic targets

31 March 2020

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The efficacy of inhibiting tumour necrosis factor alpha and interleukin 1 in patients with rheumatoid arthritis: a meta-analysis and adjusted indirect comparisons

31 March 2020

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Adalimumab with or without methotrexate in juvenile rheumatoid arthritis

31 March 2020

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Sustained response to anakinra in ankylosing spondylitis.

31 March 2020

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Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: meta-analysis of placebo-controlled trials

31 March 2020

1 reference

Safety and efficacy of alefacept, efalizumab, etanercept and infliximab in treating moderate to severe plaque psoriasis: a meta-analysis of randomized controlled trials

31 March 2020

1 reference

Infliximab efficacy and safety against refractory systemic necrotising vasculitides: long-term follow-up of 15 patients

31 March 2020

1 reference

The protein kinase complement of the human genome

31 March 2020

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Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling

31 March 2020

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The mouse kinome: discovery and comparative genomics of all mouse protein kinases

31 March 2020

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Molecular recognitions in the MAP kinase cascades

31 March 2020

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Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases

31 March 2020

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Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo

31 March 2020

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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

31 March 2020

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When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction

31 March 2020

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Limiting inflammatory responses during activation of innate immunity

31 March 2020

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The interleukin-1beta gene is transcribed from a poised promoter architecture in monocytes

31 March 2020

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p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts

31 March 2020

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Intracellular pattern recognition receptors in the host response

31 March 2020

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P2 purinergic receptor modulation of cytokine production

31 March 2020

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MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis

31 March 2020

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Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper

31 March 2020

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Structural basis for a high affinity inhibitor bound to protein kinase MK2

31 March 2020

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The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

31 March 2020

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Role of a cysteine residue in the active site of ERK and the MAPKK family

31 March 2020

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Structural basis of docking interactions between ERK2 and MAP kinase phosphatase 3.

31 March 2020

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Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling.

31 March 2020

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Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

31 March 2020

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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

31 March 2020

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IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

31 March 2020

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Mekk3 is essential for early embryonic cardiovascular development

31 March 2020

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Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3

31 March 2020

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Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis

31 March 2020

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Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis

31 March 2020

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TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity

31 March 2020

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Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development

31 March 2020

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Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation

31 March 2020

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Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

31 March 2020

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Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium

31 March 2020

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A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase

31 March 2020

1 reference

Discovery of thieno[2,3-c]pyridines as potent COT inhibitors

31 March 2020

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Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.

31 March 2020

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Selective Itk inhibitors block T-cell activation and murine lung inflammation

31 March 2020

1 reference

Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor

31 March 2020

1 reference

Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

31 March 2020

1 reference

In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: Modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models

31 March 2020

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Protein kinases as small molecule inhibitor targets in inflammation.

31 March 2020

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p38 MAP kinase inhibitors: many are made, but few are chosen.

31 March 2020

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12 December 2020

Drug evaluation: VX-702, a MAP kinase inhibitor for rheumatoid arthritis and acute coronary syndrome.

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12 December 2020

Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis

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12 December 2020

The regulation of the human tumor necrosis factor alpha promoter region in macrophage, T cell, and B cell lines

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12 December 2020

Use of cell permeable NBD peptides for suppression of inflammation

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12 December 2020

Peptides as signaling inhibitors for mammalian MAP kinase cascades

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12 December 2020

Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate.

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12 December 2020

Imatinib treatment of seropositive arthritis in a young woman with chronic myeloid leukemia.

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12 December 2020

Identifiers

DOI

10.1038/NRD2829

1 reference

20 August 2017

1 reference

PubMed ID

19483709