(Q37610142)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19810775%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

review article

1 reference

title

Predicting the clinical relevance of drug interactions from pre-approval studies (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19810775%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

0 references

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19810775%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

author name string

Silvio Caccia

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19810775%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Silvio Garattini

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19810775%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Luca Pasina

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19810775%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

publication date

1 January 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19810775%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19810775%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19810775%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19810775%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

1017-1039

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19810775%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.2165/11316630-000000000-00000

9 February 2020

exact match

0 references

cites work

Withdrawal of Posicor from market.

1 reference

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Genetic susceptibility to adverse effects of drugs and environmental toxicants. The role of the CYP family of enzymes

21 January 2018

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The Conduct of In Vitro and In Vivo Drug-Drug Interaction Studies: A PhRMA Perspective

21 January 2018

1 reference

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Sex is a major determinant of CYP3A4 expression in human liver

21 January 2018

1 reference

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Prediction of P-glycoprotein substrates by a support vector machine approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11316630-000000000-00000

Optimising drug treatment for elderly people: the prescribing cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11316630-000000000-00000

Incidence of hospitalized rhabdomyolysis in patients treated with lipid-lowering drugs

21 January 2018

1 reference

12 December 2020

Information deficits in the summary of product characteristics preclude an optimal management of drug interactions: a comparison with evidence from the literature

1 reference

12 December 2020

The relationship between number of drugs and potential drug-drug interactions in the elderly: a study of over 600,000 elderly patients from the Swedish Prescribed Drug Register

1 reference

12 December 2020

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

1 reference

12 December 2020

Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes

1 reference

12 December 2020

The association of inappropriate drug use with hospitalisation and mortality: a population-based study of the very old

1 reference

12 December 2020

Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies.

1 reference

12 December 2020

Selective deficiency of debrisoquine 4-hydroxylase activity in mouse liver microsomes.

1 reference

12 December 2020

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver

1 reference

12 December 2020

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

1 reference

12 December 2020

Drug-drug interactions among elderly patients hospitalized for drug toxicity

1 reference

12 December 2020

Aspirin, ibuprofen, and mortality after myocardial infarction: retrospective cohort study

1 reference

12 December 2020

A clinical evaluation of the Janus Web Application, a software screening tool for drug-drug interactions

1 reference

12 December 2020

1 reference

12 December 2020

CYP induction-mediated drug interactions: in vitro assessment and clinical implications

1 reference

12 December 2020

Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.

1 reference

12 December 2020

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

1 reference

12 December 2020

Prevalence and predictors of potential drug-drug interactions in Regione Emilia-Romagna, Italy

1 reference

12 December 2020

Is the number of prescribing physicians an independent risk factor for adverse drug events in an elderly outpatient population?

1 reference

12 December 2020

Progress towards prediction of human pharmacokinetic parameters from in vitro technologies.

1 reference

12 December 2020

Sex and racial differences in pharmacological response: where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics

1 reference

12 December 2020

Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain

1 reference

12 December 2020

Measuring patient safety in ambulatory care: potential for identifying medical group drug-drug interaction rates using claims data

1 reference

12 December 2020

Gemfibrozil greatly increases plasma concentrations of cerivastatin

1 reference

12 December 2020

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

1 reference

12 December 2020

Potential pitfalls of disease-specific guidelines for patients with multiple conditions

1 reference

12 December 2020

Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.

1 reference

12 December 2020

Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions

1 reference

12 December 2020

Incidence of adverse drug reactions in paediatric in/out-patients: a systematic review and meta-analysis of prospective studies

1 reference

12 December 2020

Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.

1 reference

12 December 2020

Proposal for a new tool to evaluate drug interaction cases

1 reference

12 December 2020

In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model

1 reference

12 December 2020

Predicting inductive drug-drug interactions

1 reference

12 December 2020

Mibefradil, a novel calcium antagonist, in elderly patients with hypertension: favorable hemodynamics and pharmacokinetics

1 reference

12 December 2020

Polypharmacy: a new paradigm for quality drug therapy in the elderly?

1 reference

12 December 2020

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

1 reference

12 December 2020

Gender in the pharmacy: does it matter?

1 reference

12 December 2020

Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells.

1 reference

12 December 2020

Incidence and severity of potential drug-dietary supplement interactions in primary care patients: an exploratory study of 2 outpatient practices

1 reference

12 December 2020

Clinically relevant pharmacology of selective serotonin reuptake inhibitors. An overview with emphasis on pharmacokinetics and effects on oxidative drug metabolism

1 reference

12 December 2020

Increase in non-evidence based use of antidepressants in children is cause for concern.

1 reference

12 December 2020

Evaluation of drug interaction microcomputer software: an updated comparison

1 reference

12 December 2020

The challenge of managing drug interactions in elderly people

1 reference

12 December 2020

Potential for conflict of interest in the evaluation of suspected adverse drug reactions: use of cerivastatin and risk of rhabdomyolysis

1 reference

12 December 2020

Metabolism of the newer antidepressants. An overview of the pharmacological and pharmacokinetic implications

1 reference

12 December 2020

Human drug metabolism and the cytochromes P450: application and relevance of in vitro models

1 reference

12 December 2020

Drug-drug interactions related to hospital admissions in older adults: a prospective study of 1000 patients

1 reference

12 December 2020

Drug interactions with St John's wort : mechanisms and clinical implications

1 reference

12 December 2020

Antidepressant-like components of Hypericum perforatum extracts: an overview of their pharmacokinetics and metabolism

1 reference

12 December 2020

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

1 reference

12 December 2020

Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties

1 reference

12 December 2020

Improvement in the handling of drug-drug interactions

1 reference

12 December 2020

Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells

1 reference

12 December 2020

Preventing drug interactions by online prescription screening in community pharmacies and medical practices

1 reference

12 December 2020

Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines

1 reference

12 December 2020

Life-threatening interaction of mibefradil and beta-blockers with dihydropyridine calcium channel blockers.

1 reference

12 December 2020

Active drug safety surveillance: a tool to improve public health.

1 reference

12 December 2020

Cytochrome P450 enzyme polymorphisms and adverse drug reactions

1 reference

12 December 2020

Cyclooxygenase inhibitors and the antiplatelet effects of aspirin

1 reference

12 December 2020

Prescribers' knowledge of and sources of information for potential drug-drug interactions: a postal survey of US prescribers

1 reference

12 December 2020

1 reference

12 December 2020

Drug-drug interactions in a geriatric outpatient cohort: prevalence and relevance.

1 reference

12 December 2020

Age and cytochrome P450-linked drug metabolism in humans: an analysis of 226 subjects with equal histopathologic conditions

1 reference

12 December 2020

Comparison of immortalized Fa2N-4 cells and human hepatocytes as in vitro models for cytochrome P450 induction

1 reference

12 December 2020

Increased drug delivery to the brain by P-glycoprotein inhibition

1 reference

12 December 2020

Nuclear receptor regulation of hepatic function

1 reference

12 December 2020

Comparative assessment of four drug interaction compendia

1 reference

12 December 2020

Safety of mibefradil, a new once-a-day, selective T-type calcium channel antagonist.

1 reference

12 December 2020

Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction

1 reference

12 December 2020

Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice

1 reference

12 December 2020

When good drugs go bad.

1 reference

12 December 2020

Women in early-phase clinical drug trials: have things changed over the past 20 years?

1 reference

12 December 2020

Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations

1 reference

12 December 2020

The role of P-glycoprotein and organic anion-transporting polypeptides in drug interactions

1 reference

12 December 2020

Adverse drug reactions and off-label drug use in paediatric outpatients

1 reference

12 December 2020

The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man.

1 reference

12 December 2020

Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line

1 reference

12 December 2020

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

1 reference

12 December 2020

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans

1 reference

12 December 2020

Pharmacogenetics: From Bench to Byte

1 reference

12 December 2020

1 reference

12 December 2020

Metabolic interactions between mibefradil and HMG-CoA reductase inhibitors: linking in vitro with in vivo information

1 reference

12 December 2020

The molecular basis for differential dioxin sensitivity in birds: role of the aryl hydrocarbon receptor

1 reference

12 December 2020

Gender differences in the membrane transport of endogenous and exogenous compounds

1 reference

12 December 2020

The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

1 reference

12 December 2020

Hospitalisations and emergency department visits due to drug-drug interactions: a literature review

1 reference

12 December 2020

Database analyses for the prediction of in vivo drug-drug interactions from in vitro data

1 reference

12 December 2020

Pharmacokinetic analysis of bioequivalence trials: implications for sex-related issues in clinical pharmacology and biopharmaceutics

1 reference

12 December 2020

Pharmacokinetic interactions with rifampicin : clinical relevance

1 reference

12 December 2020

Effect of ibuprofen on cardioprotective effect of aspirin

1 reference

12 December 2020

Mibefradil but not isradipine substantially elevates the plasma concentrations of the CYP3A4 substrate triazolam

1 reference

12 December 2020

Pathophysiological factors affecting CAR gene expression.

1 reference

12 December 2020

Identification of drug interactions in hospitals--computerized screening vs. bedside recording

1 reference

12 December 2020

Drug metabolism and ageing

1 reference

12 December 2020

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus

1 reference

12 December 2020

The effects of nonselective non-aspirin non-steroidal anti-inflammatory medications on the risk of nonfatal myocardial infarction and their interaction with aspirin

1 reference

12 December 2020

Pharmacokinetic overview of oral second-generation H1 antihistamines.

1 reference

12 December 2020

Improving recognition of drug interactions: benefits and barriers to using automated drug alerts

1 reference

12 December 2020

Drug-drug interactions of new active substances: mibefradil example

1 reference

12 December 2020

Application of support vector machines to in silico prediction of cytochrome p450 enzyme substrates and inhibitors.

1 reference

12 December 2020

Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction

1 reference

12 December 2020

Biologic and molecular mechanisms for sex differences in pharmacokinetics, pharmacodynamics, and pharmacogenetics: Part II.

1 reference

12 December 2020

Exposure to potential drug interactions in primary health care

1 reference

12 December 2020

Insights into drug metabolism from modelling studies of cytochrome P450-drug interactions.

1 reference

12 December 2020

PXR, CAR and drug metabolism

1 reference

12 December 2020

Interaction risk with proton pump inhibitors in general practice: significant disagreement between different drug-related information sources

1 reference

12 December 2020

In silico prediction of pregnane X receptor activators by machine learning approaches.

1 reference

12 December 2020

Drug interactions in primary care: impact of a new algorithm on risk determination

1 reference

12 December 2020

Clinical pharmacology: special safety considerations in drug development and pharmacovigilance

1 reference

12 December 2020

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

1 reference

12 December 2020

Clinical-pharmacological strategies to assess drug interaction potential during drug development

1 reference

12 December 2020

Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition

1 reference

12 December 2020

Polypharmacy, adverse drug-related events, and potential adverse drug interactions in elderly patients presenting to an emergency department

1 reference

12 December 2020

Prediction of cytochrome P450 3A4, 2D6, and 2C9 inhibitors and substrates by using support vector machines.

1 reference

12 December 2020

Do too many cooks spoil the broth? Multiple physician involvement in medical management of elderly patients and potentially inappropriate drug combinations

1 reference

12 December 2020

The human genome project and novel aspects of cytochrome P450 research

1 reference

12 December 2020

Predicting in vivo drug interactions from in vitro drug discovery data

1 reference

12 December 2020

Transporter-mediated drug interactions: clinical implications and in vitro assessment

1 reference

12 December 2020

Drug interaction prediction using ontology-driven hypothetical assertion framework for pathway generation followed by numerical simulation

1 reference

12 December 2020

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

1 reference

12 December 2020

Pediatric drug labeling: improving the safety and efficacy of pediatric therapies

1 reference

12 December 2020

Drugs as CYP3A probes, inducers, and inhibitors

1 reference

12 December 2020

Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse

1 reference

12 December 2020

Identification of amino acids in rat pregnane X receptor that determine species-specific activation

1 reference

12 December 2020

Drug-drug interactions in the elderly

1 reference

12 December 2020

Herb-drug interactions: a literature review

1 reference

12 December 2020

Female gender as a risk factor for drug-induced cardiac arrhythmias: evaluation of clinical and experimental evidence.

1 reference

12 December 2020

What will be the role of pharmacogenetics in evaluating drug safety and minimising adverse effects?

1 reference

12 December 2020

Induction of drug metabolizing enzymes: a survey of in vitro methodologies and interpretations used in the pharmaceutical industry--do they comply with FDA recommendations?

1 reference

12 December 2020

Assessment of potential drug-drug interactions with a prescription claims database

1 reference

12 December 2020

When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly

1 reference

12 December 2020

A literature review on off-label drug use in children

1 reference

12 December 2020

Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: focus on in vitro studies.

1 reference

12 December 2020

Sex differences in pharmacokinetics and pharmacodynamics

1 reference

12 December 2020

St John's wort (Hypericum perforatum): drug interactions and clinical outcomes

1 reference

12 December 2020

Drug development and use in the elderly: search for the right dose and dosing regimen (Parts I and II).

1 reference

12 December 2020

Predicting drug metabolism induction in silico

1 reference

12 December 2020

Drug-drug and drug-disease interactions in the ED: analysis of a high-risk population

1 reference

12 December 2020

Comparison of two immortalized human cell lines to study nuclear receptor-mediated CYP3A4 induction.

1 reference

12 December 2020

Women in clinical trials--a portfolio for success

1 reference

12 December 2020

Chimeric mice with humanized liver

1 reference

12 December 2020

The influence of sex on pharmacokinetics

1 reference

12 December 2020

The awareness among paediatricians of off-label prescribing in children: a survey of Italian hospitals.

1 reference

12 December 2020

Appropriate prescribing in elderly people: how well can it be measured and optimised?

1 reference

12 December 2020

Sense and nonsense in the prediction of drug-drug interactions

1 reference

12 December 2020

Postmarketing reports of QT prolongation and ventricular arrhythmia in association with cisapride and Food and Drug Administration regulatory actions

1 reference

12 December 2020

Human CYP2A6 is induced by estrogen via estrogen receptor.

1 reference

12 December 2020

Representation of the elderly, women, and minorities in heart failure clinical trials

1 reference

12 December 2020

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

1 reference

12 December 2020

Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance

1 reference

12 December 2020

Induction of CYP1A1. The AhR/DRE paradigm: transcription, receptor regulation, and expanding biological roles

1 reference

12 December 2020

Application of in silico approaches to predicting drug--drug interactions

1 reference

12 December 2020

Calcium-channel blocker verapamil administration in prolonged and refractory status epilepticus

1 reference

12 December 2020

N-dealkylation of arylpiperazine derivatives: disposition and metabolism of the 1-aryl-piperazines formed

1 reference

12 December 2020

Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes.

1 reference

12 December 2020

Emerging role of drug interaction studies in drug development: the good, the bad, and the unknown.

1 reference

12 December 2020

The search for endogenous activators of the aryl hydrocarbon receptor

1 reference

12 December 2020

Use of an online surveillance system for screening drug interactions in prescriptions in community pharmacies

1 reference

12 December 2020

Manufacturer's drug interaction and postmarketing adverse event data: what are appropriate uses?

1 reference

12 December 2020

Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions

1 reference

12 December 2020

Clinically Relevant Pharmacology of Selective Serotonin Reuptake Inhibitors

1 reference

12 December 2020

Sex is a major determinant of CYP3A4 expression in human liver

1 reference

12 December 2020